DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4854 and ZNF22

DIOPT Version :9

Sequence 1:	NP_650860.1	Gene:	CG4854 / 42391	FlyBaseID:	FBgn0038766	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_008894.2	Gene:	ZNF22 / 7570	HGNCID:	13012	Length:	224	Species:	Homo sapiens

Alignment Length:	161	Identity:	68/161 - (42%)
Similarity:	85/161 - (52%)	Gaps:	13/161 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 SLSPKPVTFEDEDSGQAASFTCNICNNVYSERVKLTNHMKVHSAKKPHECEICHKRFRQTPQLAR 223
            ||..||             :.|..|...:|:...|..|.|:|:.||.|:|..|.|.|.|:..|.:
Human    49 SLDDKP-------------YKCTECEKSFSQSSTLFQHQKIHTGKKSHKCADCGKSFFQSSNLIQ 100

  Fly   224 HMNTHTGNRPYKCDYCDSRFADPSTRIKHQRIHTNERPYKCEFCSRSFGYSNVLRVHLKTHTGER 288
            |...|||.:|||||.|...|...|..|:||||||.|:||:|:.|.|.|..|:.|..|.:|||||:
Human   101 HRRIHTGEKPYKCDECGESFKQSSNLIQHQRIHTGEKPYQCDECGRCFSQSSHLIQHQRTHTGEK 165

  Fly   289 PFSCQYCQKSFSQLHHKNSHEKSHKRTKEVK 319
            |:.|..|.|.|||..|...|.|.||..|..|
Human   166 PYQCSECGKCFSQSSHLRQHMKVHKEEKPRK 196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4854	NP_650860.1	zf-AD	12..>57	CDD:285071
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		zf-H2C2_2	193..217	CDD:290200	11/23 (48%)
		COG5048	201..>258	CDD:227381	27/56 (48%)
		C2H2 Zn finger	208..228	CDD:275368	7/19 (37%)
		zf-H2C2_2	221..244	CDD:290200	11/22 (50%)
		C2H2 Zn finger	236..256	CDD:275368	9/19 (47%)
		zf-H2C2_2	251..273	CDD:290200	13/21 (62%)
		C2H2 Zn finger	264..284	CDD:275368	7/19 (37%)
		zf-H2C2_2	277..301	CDD:290200	12/23 (52%)
		C2H2 Zn finger	292..312	CDD:275368	9/19 (47%)
ZNF22	NP_008894.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		COG5048	<41..194	CDD:227381	66/157 (42%)
		C2H2 Zn finger	57..77	CDD:275368	6/19 (32%)
		C2H2 Zn finger	85..105	CDD:275368	7/19 (37%)
		C2H2 Zn finger	113..133	CDD:275368	9/19 (47%)
		C2H2 Zn finger	141..161	CDD:275368	7/19 (37%)
		C2H2 Zn finger	169..189	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2318
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860