Protein Alignment CG4854 and ZNF726

DIOPT Version :10

• Sequence 1: NP_650860.1
• Gene: CG4854 / 42391
• FlyBaseID: FBgn0038766
• Length: 319
• Species: Drosophila melanogaster
• Sequence 2: NP_001230967.1
• Gene: ZNF726 / 730087
• HGNCID: 32462
• Length: 616
• Species: Homo sapiens
• Alignment Length: 339
• Identity: 91/339 - (26%)
• Similarity: 145/339 - (42%)
• Gaps: 72/339 - (21%)

  Fly     2 HTNVDSRDLKCRICLV-------QPKDESLMPTEPDFPDKIKRCTGVELSESPDWPNRICTSCAL 59
            ||.  .:..||:.|:.       :.:.:|:..||..:  |.|.|     .::.:|.:.:...
Human   167 HTR--KKPFKCKNCVKSFCMFSHKTQHKSIYTTEKSY--KCKEC-----GKTFNWSSTLTNH--- 219

  Fly    60 LLRAALKLRSLCQQTEKDLKEQKLQEINIEIVHDEQETKKKTESRDLSKNEATGSDSELEYE--- 121
                        ::|..:.|..|.:|..          |...:|.:.:.::.|.: .|..|:
Human   220 ------------KKTHTEEKPYKCEEYG----------KAFNQSSNYTTHKVTHT-GEKPYKCEE 261

  Fly   122 ----YLDSYDVTLES---SEDVACSADELVSIEPAISAPEE-SVYS---LSPKPVTFEDEDSGQA 175
                :..|..:|:..   :.:..|..:|   ...|.|.|.. :::.   :..||
Human   262 CGKAFSQSSTLTIHKRIHTGEKPCKCEE---CGKAFSQPSALTIHKRMHIGEKP----------- 312

  Fly   176 ASFTCNICNNVYSERVKLTNHMKVHSAKKPHECEICHKRFRQTPQLARHMNTHTGNRPYKCDYCD 240
              :.|..|...:.....||.|.::||.:||::||.|.|.|.|...|..|...|||.:||||:.|.
Human   313 --YKCEECGKAFVWSSTLTRHKRLHSGEKPYKCEECAKAFSQFGHLTTHRIIHTGEKPYKCEECG 375

  Fly   241 SRFADPSTRIKHQRIHTNERPYKCEFCSRSFGYSNVLRVHLKTHTGERPFSCQYCQKSFSQLHHK 305
            ..|..|||..||:||||.|:|||||.|.::|..|:.|..|...||||:|:.|:.|.|:|....:.
Human   376 KAFIWPSTLTKHKRIHTGEKPYKCEECGKAFHRSSNLTKHKIIHTGEKPYKCEECGKAFIWSSNL 440

  Fly   306 NSHEKSHKRTKEVK 319
            ..|:|.|.|.|..|
Human   441 TEHKKIHTREKPYK 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4854	NP_650860.1	zf-AD	12..>57	CDD:214871	9/51 (18%)
		C2H2 Zn finger	180..200	CDD:275368	5/19 (26%)
		COG5048	201..>258	CDD:227381	28/56 (50%)
		C2H2 Zn finger	208..228	CDD:275368	8/19 (42%)
		zf-H2C2_2	221..244	CDD:463886	10/22 (45%)
		C2H2 Zn finger	236..256	CDD:275368	9/19 (47%)
		zf-H2C2_2	251..271	CDD:463886	13/19 (68%)
		C2H2 Zn finger	264..284	CDD:275368	7/19 (37%)
		C2H2 Zn finger	292..312	CDD:275368	6/19 (32%)
ZNF726	NP_001230967.1	KRAB	4..64	CDD:214630
		C2H2 Zn finger	145..167	CDD:275368	91/339 (27%)
		C2H2 Zn finger	175..195	CDD:275368	3/19 (16%)
		COG5048	186..612	CDD:227381	86/318 (27%)
		C2H2 Zn finger	203..223	CDD:275368	3/39 (8%)
		C2H2 Zn finger	231..251	CDD:275368	3/29 (10%)
		C2H2 Zn finger	259..279	CDD:275368	2/19 (11%)
		C2H2 Zn finger	287..307	CDD:275368	4/22 (18%)
		C2H2 Zn finger	315..335	CDD:275368	5/19 (26%)
		C2H2 Zn finger	343..363	CDD:275368	8/19 (42%)
		C2H2 Zn finger	371..391	CDD:275368	9/19 (47%)
		C2H2 Zn finger	399..419	CDD:275368	7/19 (37%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		C2H2 Zn finger	455..475	CDD:275368	91/339 (27%)
		C2H2 Zn finger	483..503	CDD:275368
		C2H2 Zn finger	511..531	CDD:275368
		C2H2 Zn finger	539..559	CDD:275368
		C2H2 Zn finger	567..587	CDD:275368
		C2H2 Zn finger	595..615	CDD:275368