Protein Alignment CG4854 and RBAK

DIOPT Version :10

• Sequence 1: NP_650860.1
• Gene: CG4854 / 42391
• FlyBaseID: FBgn0038766
• Length: 319
• Species: Drosophila melanogaster
• Sequence 2: NP_066986.1
• Gene: RBAK / 57786
• HGNCID: 17680
• Length: 714
• Species: Homo sapiens
• Alignment Length: 321
• Identity: 88/321 - (27%)
• Similarity: 129/321 - (40%)
• Gaps: 60/321 - (18%)

  Fly    54 CTSCALLLRAALKLRSL-----------CQQTEKDLKEQKLQEINIE---IVHDEQETKKK---- 100
            |.||...|.:..:|.|.           |.:..|....:|:.|.|..   ..|:|:...:|
Human   137 CVSCGKNLESISQLISSDGSYARTKPDECNECGKTYHGEKMCEFNQNGDTYSHNEENILQKISIL 201

  Fly   101 ------TESRDLSKNEAT------GSDSELEYEYLDSYDVTLESSEDVA---------------- 137
                  .|..:...|||.      ....|..||:.||....::.|...|
Human   202 EKPFEYNECMEALDNEAVFIAHKRAYIGEKPYEWNDSGPDFIQMSNFNAYQRSQMEMKPFECSEC 266

  Fly   138 ----CSADELVSIEPAISAPEESVY-------SLSPK-PVTFEDEDSGQAASFTCNICNNVYSER 190
                |...:.:..:.|.:.  |..|       |.|.| .:|.......:...:.||.|...:.::
Human   267 GKSFCKKSKFIIHQRAHTG--EKPYECNVCGKSFSQKGTLTVHRRSHLEEKPYKCNECGKTFCQK 329

  Fly   191 VKLTNHMKVHSAKKPHECEICHKRFRQTPQLARHMNTHTGNRPYKCDYCDSRFADPSTRIKHQRI 255
            :.||.|::.||.:||:||..|.|.|.|...|..|...|:|.|||.|:.|...|:..|....|||.
Human   330 LHLTQHLRTHSGEKPYECSECGKTFCQKTHLTLHQRNHSGERPYPCNECGKSFSRKSALSDHQRT 394

  Fly   256 HTNERPYKCEFCSRSFGYSNVLRVHLKTHTGERPFSCQYCQKSFSQLHHKNSHEKSHKRTK 316
            ||.|:.|||..|.:|:...:.|..|.:|||||:|:.|..|.|.||::.:...|.:||...|
Human   395 HTGEKLYKCNECGKSYYRKSTLITHQRTHTGEKPYQCSECGKFFSRVSYLTIHYRSHLEEK 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4854	NP_650860.1	zf-AD	12..>57	CDD:214871	1/2 (50%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	201..>258	CDD:227381	24/56 (43%)
		C2H2 Zn finger	208..228	CDD:275368	7/19 (37%)
		zf-H2C2_2	221..244	CDD:463886	9/22 (41%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		zf-H2C2_2	251..271	CDD:463886	10/19 (53%)
		C2H2 Zn finger	264..284	CDD:275368	5/19 (26%)
		C2H2 Zn finger	292..312	CDD:275368	6/19 (32%)
RBAK	NP_066986.1	KRAB	8..68	CDD:214630
		C2H2 Zn finger	165..199	CDD:275368	8/33 (24%)
		Required for interaction with RB1. /evidence=ECO:0000269|PubMed:10702291	171..260		17/88 (19%)
		C2H2 Zn finger	207..227	CDD:275368	4/19 (21%)
		SUF4-like	259..>307	CDD:411020	8/49 (16%)
		C2H2 Zn finger	263..284	CDD:411020	2/20 (10%)
		C2H2 Zn finger	263..283	CDD:275368	1/19 (5%)
		C2H2 Zn finger	291..311	CDD:275368	4/19 (21%)
		zf-C2H2	317..339	CDD:395048	6/21 (29%)
		C2H2 Zn finger	319..339	CDD:275368	6/19 (32%)
		COG5048	343..701	CDD:227381	47/113 (42%)
		C2H2 Zn finger	347..367	CDD:275368	7/19 (37%)
		C2H2 Zn finger	375..395	CDD:275368	7/19 (37%)
		C2H2 Zn finger	403..423	CDD:275368	5/19 (26%)
		Interaction with AR. /evidence=ECO:0000269|PubMed:14664718	417..714		16/39 (41%)
		C2H2 Zn finger	431..451	CDD:275368	6/19 (32%)
		C2H2 Zn finger	459..479	CDD:275368
		C2H2 Zn finger	513..533	CDD:275368
		C2H2 Zn finger	541..561	CDD:275368
		C2H2 Zn finger	569..589	CDD:275368
		C2H2 Zn finger	597..617	CDD:275368
		C2H2 Zn finger	625..645	CDD:275368
		C2H2 Zn finger	653..673	CDD:275368
		C2H2 Zn finger	681..701	CDD:275368