DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4854 and MYNN

DIOPT Version :9

Sequence 1:	NP_650860.1	Gene:	CG4854 / 42391	FlyBaseID:	FBgn0038766	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_001172047.1	Gene:	MYNN / 55892	HGNCID:	14955	Length:	610	Species:	Homo sapiens

Alignment Length:	351	Identity:	90/351 - (25%)
Similarity:	153/351 - (43%)	Gaps:	79/351 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 ELSESPDW--PNRICTSCALLLR--------AALKLRSL----------CQQTEKDLKEQKLQEI 86
            |:.::.|:  ...:.|.|.:.:.        ::.::.|:          |..|.:|...::..|:
Human    94 EIHQAADYLKVEEVVTKCKIKMEDFAFIANPSSTEISSITGNIELNQQTCLLTLRDYNNREKSEV 158

  Fly    87 NIEIVH----------DEQETKKKTESRDLSKNEATGSDSELEYE-----------YLDSYDVTL 130
            :.:::.          ...:||||.::.:..|   ||.:..::|.           :||:..:..
Human   159 STDLIQANPKQGALAKKSSQTKKKKKAFNSPK---TGQNKTVQYPSDILENASVELFLDANKLPT 220

  Fly   131 ESSEDVACSAD----ELVSI-----------------------EPAISAPEESVYSLSPKPVTFE 168
            ...|.||...|    ||.|:                       :|..:..|.|:.:::.....:|
Human   221 PVVEQVAQINDNSELELTSVVENTFPAQDIVHTVTVKRKRGKSQPNCALKEHSMSNIASVKSPYE 285

  Fly   169 DEDSGQ-------AASFTCNICNNVYSERVKLTNHMKVHSAKKPHECEICHKRFRQTPQLARHMN 226
            .|:||:       .|...||.|..|:||...|..||::|...||:.|.:|.|.|.|..||..|:.
Human   286 AENSGEELDQRYSKAKPMCNTCGKVFSEASSLRRHMRIHKGVKPYVCHLCGKAFTQCNQLKTHVR 350

  Fly   227 THTGNRPYKCDYCDSRFADPSTRIKHQRI-HTNERPYKCEFCSRSFGYSNVLRVHLKTHTGERPF 290
            ||||.:||||:.||..||.....:.|.|: |..|:||||:.|:..|..|:.|::|.:.|:||:|:
Human   351 THTGEKPYKCELCDKGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPY 415

  Fly   291 SCQYCQKSFSQLHHKNSHEKSHKRTK 316
            .|..|.:.|:|......|.:.|...|
Human   416 VCDRCGQRFAQASTLTYHVRRHTGEK 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4854	NP_650860.1	zf-AD	12..>57	CDD:285071	3/16 (19%)
		C2H2 Zn finger	180..200	CDD:275368	9/19 (47%)
		zf-H2C2_2	193..217	CDD:290200	10/23 (43%)
		COG5048	201..>258	CDD:227381	25/57 (44%)
		C2H2 Zn finger	208..228	CDD:275368	8/19 (42%)
		zf-H2C2_2	221..244	CDD:290200	12/22 (55%)
		C2H2 Zn finger	236..256	CDD:275368	7/20 (35%)
		zf-H2C2_2	251..273	CDD:290200	10/22 (45%)
		C2H2 Zn finger	264..284	CDD:275368	6/19 (32%)
		zf-H2C2_2	277..301	CDD:290200	9/23 (39%)
		C2H2 Zn finger	292..312	CDD:275368	5/19 (26%)
MYNN	NP_001172047.1	BTB	14..115	CDD:306997	4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..197		7/30 (23%)
		Nuclear localization signal. /evidence=ECO:0000255	174..190		4/15 (27%)
		Nuclear localization signal. /evidence=ECO:0000255	257..262		0/4 (0%)
		C2H2 Zn finger	304..324	CDD:275368	9/19 (47%)
		zf-C2H2	304..324	CDD:306579	9/19 (47%)
		zf-H2C2_2	316..341	CDD:316026	10/24 (42%)
		C2H2 Zn finger	332..352	CDD:275368	8/19 (42%)
		zf-H2C2_2	345..369	CDD:316026	13/23 (57%)
		SFP1	<354..438	CDD:227516	31/83 (37%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	389..409	CDD:275368	6/19 (32%)
		C2H2 Zn finger	417..437	CDD:275368	5/19 (26%)
		zf-H2C2_2	430..453	CDD:316026	3/12 (25%)
		SFP1	<439..522	CDD:227516	1/3 (33%)
		C2H2 Zn finger	445..465	CDD:275368
		C2H2 Zn finger	473..493	CDD:275368
		C2H2 Zn finger	501..522	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..556
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910