DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4854 and ZNF793

DIOPT Version :9

Sequence 1:	NP_650860.1	Gene:	CG4854 / 42391	FlyBaseID:	FBgn0038766	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_001013681.2	Gene:	ZNF793 / 390927	HGNCID:	33115	Length:	406	Species:	Homo sapiens

Alignment Length:	327	Identity:	93/327 - (28%)
Similarity:	136/327 - (41%)	Gaps:	57/327 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 PDKIKRCTGVELSESPDWPNRICTSC-----------------ALLLR--AALKLRSLCQQTEKD 77
            ||.|.|   :|..|:|......|..|                 .:|||  ||:..::|  ..||.
Human    54 PDVILR---LEQEEAPWIGEAACPGCHCWEDIWRVNIQRKRRQDMLLRPGAAISKKTL--PKEKS 113

  Fly    78 LKEQKLQEINI---EIVHDEQET-------KKKTESRDL---SKNEATGSDSELEYEYL---DSY 126
            .:..|..:|::   ::....|..       |....:.||   .:|.|...|....|..|   .::
Human   114 CEYNKFGKISLLSTDLFSSIQSPSNWNPCGKNLNHNLDLIGFKRNCAKKQDECYAYGKLLQRINH 178

  Fly   127 DVTLESSEDVACSADE-------LVSIEPAISAPEESVYSLSPKPVTFEDEDSGQAASFTCNICN 184
            .......:...||..|       .:..:||:|  :..:|.....|.|.:..        .|:.|.
Human   179 GRRPNGEKPRGCSHCEKAFTQNPALMYKPAVS--DSLLYKRKRVPPTEKPH--------VCSECG 233

  Fly   185 NVYSERVKLTNHMKVHSAKKPHECEICHKRFRQTPQLARHMNTHTGNRPYKCDYCDSRFADPSTR 249
            ..:..:.:...|.:.|:.:||:.|..|.|.|.....|.:|...|||.||::|.:|...|...|.|
Human   234 KAFCYKSEFIRHQRSHTGEKPYGCTDCGKAFSHKSTLIKHQRIHTGVRPFECFFCGKAFTQKSHR 298

  Fly   250 IKHQRIHTNERPYKCEFCSRSFGYSNVLRVHLKTHTGERPFSCQYCQKSFSQLHHKNSHEKSHKR 314
            .:|||.||.|||:.|..|.:|||..:.|.||.|.||||||:.|:.|.|||||....|.|.::|..
Human   299 TEHQRTHTGERPFVCSECGKSFGEKSYLNVHRKMHTGERPYRCRECGKSFSQKSCLNKHWRTHTG 363

  Fly   315 TK 316
            .|
Human   364 EK 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4854	NP_650860.1	zf-AD	12..>57	CDD:285071	8/24 (33%)
		C2H2 Zn finger	180..200	CDD:275368	3/19 (16%)
		zf-H2C2_2	193..217	CDD:290200	8/23 (35%)
		COG5048	201..>258	CDD:227381	22/56 (39%)
		C2H2 Zn finger	208..228	CDD:275368	6/19 (32%)
		zf-H2C2_2	221..244	CDD:290200	9/22 (41%)
		C2H2 Zn finger	236..256	CDD:275368	8/19 (42%)
		zf-H2C2_2	251..273	CDD:290200	12/21 (57%)
		C2H2 Zn finger	264..284	CDD:275368	9/19 (47%)
		zf-H2C2_2	277..301	CDD:290200	15/23 (65%)
		C2H2 Zn finger	292..312	CDD:275368	9/19 (47%)
ZNF793	NP_001013681.2	KRAB	8..68	CDD:214630	7/16 (44%)
		C2H2 Zn finger	190..221	CDD:275368	7/32 (22%)
		COG5048	<225..385	CDD:227381	56/149 (38%)
		C2H2 Zn finger	229..249	CDD:275368	3/19 (16%)
		C2H2 Zn finger	257..277	CDD:275368	6/19 (32%)
		C2H2 Zn finger	285..305	CDD:275368	8/19 (42%)
		C2H2 Zn finger	313..333	CDD:275368	9/19 (47%)
		C2H2 Zn finger	341..361	CDD:275368	9/19 (47%)
		C2H2 Zn finger	369..389	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910