DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4854 and ZNF568

DIOPT Version :9

Sequence 1:	NP_650860.1	Gene:	CG4854 / 42391	FlyBaseID:	FBgn0038766	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_940941.2	Gene:	ZNF568 / 374900	HGNCID:	25392	Length:	644	Species:	Homo sapiens

Alignment Length:	258	Identity:	83/258 - (32%)
Similarity:	123/258 - (47%)	Gaps:	34/258 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 QTEKDLKEQ------KLQEINIEIVHDEQ--ETKKKTESRDLSKNEATGSDSELEYEYLDSYDVT 129
            :.::.:|:|      |:..|:.:|:..|:  |.||..:...||.:..|...|   :...||.|..
Human   123 EVDEQIKKQQETLVRKVTSISKKILIKEKVIECKKVAKIFPLSSDIVTSRQS---FYDCDSLDKG 184

  Fly   130 LESSEDVACSADELVSIEPAISAPEES------VYSLSPKPVTFEDEDSGQAASFTCNICNNVYS 188
            ||.:.|       |:..|......::|      .|..:...||          .|.||.|...:|
Human   185 LEHNLD-------LLRYEKGCVREKQSNEFGKPFYHCASYVVT----------PFKCNQCGQDFS 232

  Fly   189 ERVKLTNHMKVHSAKKPHECEICHKRFRQTPQLARHMNTHTGNRPYKCDYCDSRFADPSTRIKHQ 253
            .:..|..|.::|:.:||:||:.|.|.|.:...|..|...|||.:||||:.|...|...|..|:|.
Human   233 HKFDLIRHERIHAGEKPYECKECGKAFSRKENLITHQKIHTGEKPYKCNECGKAFIQMSNLIRHH 297

  Fly   254 RIHTNERPYKCEFCSRSFGYSNVLRVHLKTHTGERPFSCQYCQKSFSQLHHKNSHEKSHKRTK 316
            ||||.|:||.|:.|.::|...:.|..|.:.||||:|:.|:.|.|||||..:...|||.|...|
Human   298 RIHTGEKPYACKDCWKAFSQKSNLIEHERIHTGEKPYECKECGKSFSQKQNLIEHEKIHTGEK 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4854	NP_650860.1	zf-AD	12..>57	CDD:285071
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		zf-H2C2_2	193..217	CDD:290200	10/23 (43%)
		COG5048	201..>258	CDD:227381	24/56 (43%)
		C2H2 Zn finger	208..228	CDD:275368	6/19 (32%)
		zf-H2C2_2	221..244	CDD:290200	10/22 (45%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		zf-H2C2_2	251..273	CDD:290200	11/21 (52%)
		C2H2 Zn finger	264..284	CDD:275368	5/19 (26%)
		zf-H2C2_2	277..301	CDD:290200	12/23 (52%)
		C2H2 Zn finger	292..312	CDD:275368	10/19 (53%)
ZNF568	NP_940941.2	KRAB	48..102	CDD:214630
		KRAB	48..87	CDD:279668
		C2H2 Zn finger	224..244	CDD:275368	6/19 (32%)
		zf-H2C2_2	236..261	CDD:290200	10/24 (42%)
		COG5048	248..634	CDD:227381	50/113 (44%)
		C2H2 Zn finger	252..272	CDD:275368	6/19 (32%)
		zf-H2C2_2	264..289	CDD:290200	11/24 (46%)
		C2H2 Zn finger	280..300	CDD:275368	7/19 (37%)
		zf-H2C2_2	292..317	CDD:290200	12/24 (50%)
		C2H2 Zn finger	308..328	CDD:275368	5/19 (26%)
		zf-H2C2_2	320..345	CDD:290200	12/24 (50%)
		C2H2 Zn finger	336..356	CDD:275368	10/19 (53%)
		zf-H2C2_2	348..373	CDD:290200	5/13 (38%)
		C2H2 Zn finger	364..384	CDD:275368
		zf-H2C2_2	380..401	CDD:290200
		C2H2 Zn finger	392..412	CDD:275368
		zf-H2C2_2	408..429	CDD:290200
		C2H2 Zn finger	420..440	CDD:275368
		zf-H2C2_2	432..457	CDD:290200
		C2H2 Zn finger	448..468	CDD:275368
		zf-H2C2_2	460..485	CDD:290200
		C2H2 Zn finger	476..496	CDD:275368
		zf-H2C2_2	488..513	CDD:290200
		C2H2 Zn finger	504..524	CDD:275368
		zf-H2C2_2	516..541	CDD:290200
		C2H2 Zn finger	532..552	CDD:275368
		zf-H2C2_2	544..569	CDD:290200
		C2H2 Zn finger	560..580	CDD:275368
		zf-H2C2_2	572..597	CDD:290200
		C2H2 Zn finger	588..608	CDD:275368
		zf-H2C2_2	601..625	CDD:290200
		C2H2 Zn finger	616..636	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910