DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4854 and Zfp819

DIOPT Version :9

Sequence 1:	NP_650860.1	Gene:	CG4854 / 42391	FlyBaseID:	FBgn0038766	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_001014039.1	Gene:	Zfp819 / 308561	RGDID:	1309564	Length:	614	Species:	Rattus norvegicus

Alignment Length:	354	Identity:	97/354 - (27%)
Similarity:	149/354 - (42%)	Gaps:	98/354 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VDSRDLKCRICLVQPKDESLMPTEPDFPDKIKRCTGVELSESPDWPNRICT--SCALLL--RAAL 65
            |||    ||:| .|....::..|         ..||          .|.||  .||.:|  |:.|
  Rat   224 VDS----CRLC-TQGLSSAVCTT---------HSTG----------ERACTGNQCANVLSPRSPL 264

  Fly    66 KLRSLCQQTEKDLKEQKLQEINIEIVHDEQETKKKTESRDLSKNEATGSDSELEYEYL-----DS 125
            :...:..|.|.           :|...||    |...:...|..:.|.:..:||..::     .|
  Rat   265 RQHGILSQDEP-----------VEYTKDE----KAFTAGSASCEQQTTNTLDLETHFICHICGKS 314

  Fly   126 YDVTLESSEDVACSADELVSIEPAISAPEESVY-------SLSPKPVTFED-------------E 170
            :   |:.||         :|..|..|. ||:.|       ||:..|.:.:.             .
  Rat   315 F---LQKSE---------LSFHPGTSR-EETRYECPDCLKSLTTSPSSLQAHHEAHTKQKPYTCH 366

  Fly   171 DSGQAAS-----------------FTCNICNNVYSERVKLTNHMKVHSAKKPHECEICHKRFRQT 218
            |.|::.|                 :.|:.|...:|::..||.|.::|:.:||:.|..|.|.|...
  Rat   367 DCGKSFSYASHLKVHLRIHTGERPYVCSDCGKAFSQKSVLTTHQRIHTGEKPYACSHCGKLFVYA 431

  Fly   219 PQLARHMNTHTGNRPYKCDYCDSRFADPSTRIKHQRIHTNERPYKCEFCSRSFGYSNVLRVHLKT 283
            ..|.:|...|||.:||:|..|...|::.|....|:||||.|:||||..|.:||...:.|:||.:|
  Rat   432 SDLRKHSRFHTGEKPYECRDCGKVFSNKSHLPVHRRIHTGEKPYKCRDCGKSFRRKSHLQVHGRT 496

  Fly   284 HTGERPFSCQYCQKSFSQLHHKNSHEKSH 312
            ||||:|::|..|.|:||.....::|::.|
  Rat   497 HTGEKPYACPDCGKAFSHSSVLSTHQRIH 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4854	NP_650860.1	zf-AD	12..>57	CDD:285071	10/46 (22%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		zf-H2C2_2	193..217	CDD:290200	10/23 (43%)
		COG5048	201..>258	CDD:227381	21/56 (38%)
		C2H2 Zn finger	208..228	CDD:275368	6/19 (32%)
		zf-H2C2_2	221..244	CDD:290200	9/22 (41%)
		C2H2 Zn finger	236..256	CDD:275368	6/19 (32%)
		zf-H2C2_2	251..273	CDD:290200	13/21 (62%)
		C2H2 Zn finger	264..284	CDD:275368	7/19 (37%)
		zf-H2C2_2	277..301	CDD:290200	13/23 (57%)
		C2H2 Zn finger	292..312	CDD:275368	6/19 (32%)
Zfp819	NP_001014039.1	KRAB	27..81	CDD:214630
		C2H2 Zn finger	336..357	CDD:275368	3/20 (15%)
		COG5048	<346..538	CDD:227381	57/180 (32%)
		C2H2 Zn finger	365..385	CDD:275368	3/19 (16%)
		C2H2 Zn finger	393..413	CDD:275368	6/19 (32%)
		C2H2 Zn finger	421..441	CDD:275368	6/19 (32%)
		C2H2 Zn finger	449..469	CDD:275368	6/19 (32%)
		C2H2 Zn finger	477..497	CDD:275368	7/19 (37%)
		SFP1	<499..582	CDD:227516	10/27 (37%)
		C2H2 Zn finger	505..525	CDD:275368	6/19 (32%)
		C2H2 Zn finger	533..553	CDD:275368
		C2H2 Zn finger	561..581	CDD:275368
		zf-H2C2_2	573..598	CDD:404364
		C2H2 Zn finger	589..609	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000