DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4854 and ZNF485

DIOPT Version :9

Sequence 1:	NP_650860.1	Gene:	CG4854 / 42391	FlyBaseID:	FBgn0038766	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_001305069.1	Gene:	ZNF485 / 220992	HGNCID:	23440	Length:	441	Species:	Homo sapiens

Alignment Length:	340	Identity:	88/340 - (25%)
Similarity:	141/340 - (41%)	Gaps:	63/340 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ESLMPTEPDFPDKIKRCTGV----------ELSESPDWPNRICTSCALLLRAALKLRSL------ 70
            |....||.::  |.|.|..|          :.:.:.:.|:: |..|.:   |.:...||
Human   121 EGRSSTEKNY--KCKECGKVFKYNSSFISHQRNHTSEKPHK-CKECGI---AFMNSSSLLNHHKV 179

  Fly    71 --------CQQTEKDLKEQKLQEINIEIVHDEQETKKKTE-SRDLSKNEATGSDSELEYEYLDSY 126
                    |.:..|.||:.. ..||.:.:|..::..|..| .:...||....|...:.
Human   180 HAGKQPYRCIECGKFLKKHS-TFINHQRIHSREKPHKCIECGKTFRKNSILLSHQRIH------- 236

  Fly   127 DVTLESSEDVACSADELVSIEPAISAPEESVYSLSPKPVTFEDEDSGQA---------------- 175
                ...:...|:.......:.|.....|.::| ..||  |:....|:|
Human   237 ----TGQKPYKCNDCGKAFAQNAALTRHERIHS-GEKP--FKCNKCGRAFRDNSTVLEHQKIHTG 294

  Fly   176 -ASFTCNICNNVYSERVKLTNHMKVHSAKKPHECEICHKRFRQTPQLARHMNTHTGNRPYKCDYC 239
             ..:.||.|...:.:...|.:|.::|:.:||:.|..|.|.||.:...|.|..||:||:||:|..|
Human   295 EKPYQCNECGKAFRKSSTLISHQRMHTGEKPYHCSKCGKSFRYSSSFAGHQKTHSGNKPYQCRDC 359

  Fly   240 DSRFADPSTRIKHQRIHTNERPYKCEFCSRSFGYSNVLRVHLKTHTGERPFSCQYCQKSFSQLHH 304
            ...|...||...||||||.|:||.|:.|.::|.:|:.|..|.:.||||:|:.|..|.|:|.:...
Human   360 GKAFTKSSTLTGHQRIHTGEKPYHCKKCGKAFRHSSGLVEHQRLHTGEKPYKCNECGKAFPRSSA 424

  Fly   305 KNSHEKSHKRTKEVK 319
            ...|:|.|.:.:.:|
Human   425 LKQHKKIHNKERAMK 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4854	NP_650860.1	zf-AD	12..>57	CDD:285071	9/44 (20%)
		C2H2 Zn finger	180..200	CDD:275368	5/19 (26%)
		zf-H2C2_2	193..217	CDD:290200	9/23 (39%)
		COG5048	201..>258	CDD:227381	25/56 (45%)
		C2H2 Zn finger	208..228	CDD:275368	7/19 (37%)
		zf-H2C2_2	221..244	CDD:290200	10/22 (45%)
		C2H2 Zn finger	236..256	CDD:275368	8/19 (42%)
		zf-H2C2_2	251..273	CDD:290200	12/21 (57%)
		C2H2 Zn finger	264..284	CDD:275368	6/19 (32%)
		zf-H2C2_2	277..301	CDD:290200	11/23 (48%)
		C2H2 Zn finger	292..312	CDD:275368	6/19 (32%)
ZNF485	NP_001305069.1	KRAB	11..71	CDD:214630
		KRAB	11..50	CDD:279668
		COG5048	<124..361	CDD:227381	56/257 (22%)
		C2H2 Zn finger	132..152	CDD:275368	3/19 (16%)
		C2H2 Zn finger	160..180	CDD:275368	5/22 (23%)
		C2H2 Zn finger	188..208	CDD:275368	6/20 (30%)
		C2H2 Zn finger	216..236	CDD:275368	4/19 (21%)
		zf-H2C2_2	229..253	CDD:290200	2/34 (6%)
		C2H2 Zn finger	244..264	CDD:275368	3/19 (16%)
		zf-H2C2_2	256..279	CDD:290200	6/25 (24%)
		C2H2 Zn finger	272..292	CDD:275368	2/19 (11%)
		zf-H2C2_2	287..307	CDD:290200	3/19 (16%)
		C2H2 Zn finger	300..320	CDD:275368	5/19 (26%)
		zf-H2C2_2	313..337	CDD:290200	9/23 (39%)
		C2H2 Zn finger	328..348	CDD:275368	7/19 (37%)
		C2H2 Zn finger	356..376	CDD:275368	8/19 (42%)
		zf-H2C2_2	372..393	CDD:290200	12/20 (60%)
		C2H2 Zn finger	384..404	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..419	CDD:290200	10/21 (48%)
		C2H2 Zn finger	412..432	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910