DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4854 and ZNF681

DIOPT Version :9

Sequence 1:	NP_650860.1	Gene:	CG4854 / 42391	FlyBaseID:	FBgn0038766	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_612143.2	Gene:	ZNF681 / 148213	HGNCID:	26457	Length:	645	Species:	Homo sapiens

Alignment Length:	171	Identity:	58/171 - (33%)
Similarity:	91/171 - (53%)	Gaps:	19/171 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 KPVTFEDEDSGQAAS-----------------FTCNICNNVYSERVKLTNHMKVHSAKKPHECEI 210
            ||  ::.|..|:|::                 :.|..|...:::...||.|.::|:.:||::||.
Human   420 KP--YQCEKCGKASNQSSNLTEHKNIHTEEKPYKCEECGKAFNQFSNLTTHKRIHTGEKPYKCEE 482

  Fly   211 CHKRFRQTPQLARHMNTHTGNRPYKCDYCDSRFADPSTRIKHQRIHTNERPYKCEFCSRSFGYSN 275
            |.|.|.|:..|..|...|||.:.|||:.|...|...|...:|::|||.|:||.||.|.::|.:|:
Human   483 CGKAFNQSSILTTHKRIHTGEKSYKCEECGKAFYRSSKLTEHKKIHTGEKPYTCEECGKAFNHSS 547

  Fly   276 VLRVHLKTHTGERPFSCQYCQKSFSQLHHKNSHEKSHKRTK 316
            .|..|...||||:|:.|:.|.|:|:|..|...|::.|...|
Human   548 HLATHKVIHTGEKPYQCEECGKAFNQSSHLTRHKRIHTGEK 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4854	NP_650860.1	zf-AD	12..>57	CDD:285071
		C2H2 Zn finger	180..200	CDD:275368	5/19 (26%)
		zf-H2C2_2	193..217	CDD:290200	11/23 (48%)
		COG5048	201..>258	CDD:227381	22/56 (39%)
		C2H2 Zn finger	208..228	CDD:275368	8/19 (42%)
		zf-H2C2_2	221..244	CDD:290200	9/22 (41%)
		C2H2 Zn finger	236..256	CDD:275368	5/19 (26%)
		zf-H2C2_2	251..273	CDD:290200	11/21 (52%)
		C2H2 Zn finger	264..284	CDD:275368	7/19 (37%)
		zf-H2C2_2	277..301	CDD:290200	11/23 (48%)
		C2H2 Zn finger	292..312	CDD:275368	7/19 (37%)
ZNF681	NP_612143.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	144..164	CDD:275368
		C2H2 Zn finger	176..192	CDD:275368
		COG5048	198..610	CDD:227381	58/171 (34%)
		C2H2 Zn finger	200..220	CDD:275368
		C2H2 Zn finger	285..304	CDD:275368
		C2H2 Zn finger	313..332	CDD:275368
		zf-H2C2_2	324..349	CDD:290200
		C2H2 Zn finger	340..360	CDD:275368
		zf-H2C2_2	352..377	CDD:290200
		C2H2 Zn finger	368..388	CDD:275368
		zf-H2C2_2	380..404	CDD:290200
		C2H2 Zn finger	396..416	CDD:275368
		C2H2 Zn finger	424..444	CDD:275368	3/19 (16%)
		zf-H2C2_2	436..461	CDD:290200	2/24 (8%)
		C2H2 Zn finger	452..472	CDD:275368	5/19 (26%)
		zf-H2C2_2	464..489	CDD:290200	11/24 (46%)
		C2H2 Zn finger	480..500	CDD:275368	8/19 (42%)
		zf-H2C2_2	493..517	CDD:290200	10/23 (43%)
		C2H2 Zn finger	508..528	CDD:275368	5/19 (26%)
		zf-H2C2_2	521..545	CDD:290200	11/23 (48%)
		C2H2 Zn finger	536..556	CDD:275368	7/19 (37%)
		zf-H2C2_2	548..573	CDD:290200	11/24 (46%)
		C2H2 Zn finger	564..584	CDD:275368	7/19 (37%)
		zf-H2C2_2	576..601	CDD:290200	4/13 (31%)
		C2H2 Zn finger	592..612	CDD:275368
		C2H2 Zn finger	620..638	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	626..645
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000