DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4854 and ZNF98

DIOPT Version :9

Sequence 1:	NP_650860.1	Gene:	CG4854 / 42391	FlyBaseID:	FBgn0038766	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_001092096.1	Gene:	ZNF98 / 148198	HGNCID:	13174	Length:	572	Species:	Homo sapiens

Alignment Length:	353	Identity:	97/353 - (27%)
Similarity:	142/353 - (40%)	Gaps:	85/353 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 CLVQPKDESLMPTEPDFPDKIKRCTGVELSESPD---------WPN------------RICTSCA 58
            ||.|.|:          |..:||...|  :|.|.         ||.            |....|.
Human    64 CLEQGKE----------PWNVKRHEMV--TEPPVVYSYFAQDLWPKQGKKNYFQKVILRTYKKCG 116

  Fly    59 LLLRAALKLRSLCQQTE--KDLKE------QKLQEINIEIVHDEQETK--KKTESRDLSKNEATG 113
               |..|:||..|:..:  |..||      |.|.....:|...::..|  .|..:.:..|...||
Human   117 ---RENLQLRKYCKSMDECKVHKECYNGLNQCLTTTQNKIFQYDKYVKVFHKFSNSNRHKIGHTG 178

  Fly   114 SDSELEYEYLDSYDVTLESSEDVACSADELVSIEPAISAPEESVYSLSPKPVTFEDEDSGQAAS- 177
            ..|           ...:..|...|....|        |..:.::| ..||  ::.::.|:|.:
Human   179 KKS-----------FKCKECEKSFCMLSHL--------AQHKRIHS-GEKP--YKCKECGKAYNE 221

  Fly   178 ----------------FTCNICNNVYSERVKLTNHMKVHSAKKPHECEICHKRFRQTPQLARHMN 226
                            :.|..|...::....||.|..:|:.|||::||.|.|.|.|:..|..|..
Human   222 ASNLSTHKRIHTGKKPYKCEECGKAFNRLSHLTTHKIIHTGKKPYKCEECGKAFNQSANLTTHKR 286

  Fly   227 THTGNRPYKCDYCDSRFADPSTRIKHQRIHTNERPYKCEFCSRSFGYSNVLRVHLKTHTGERPFS 291
            .|||.:||||:.|...|:..||...|:.||..|:|||||.|.::|..|:.|..|...||||:.:.
Human   287 IHTGEKPYKCEECGRAFSQSSTLTAHKIIHAGEKPYKCEECGKAFSQSSTLTTHKIIHTGEKFYK 351

  Fly   292 CQYCQKSFSQLHHKNSHEKSHKRTKEVK 319
            |:.|.|:||:|.|..:|::.|...|..|
Human   352 CEECGKAFSRLSHLTTHKRIHSGEKPYK 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4854	NP_650860.1	zf-AD	12..>57	CDD:285071	13/62 (21%)
		C2H2 Zn finger	180..200	CDD:275368	5/19 (26%)
		zf-H2C2_2	193..217	CDD:290200	12/23 (52%)
		COG5048	201..>258	CDD:227381	25/56 (45%)
		C2H2 Zn finger	208..228	CDD:275368	8/19 (42%)
		zf-H2C2_2	221..244	CDD:290200	10/22 (45%)
		C2H2 Zn finger	236..256	CDD:275368	6/19 (32%)
		zf-H2C2_2	251..273	CDD:290200	11/21 (52%)
		C2H2 Zn finger	264..284	CDD:275368	7/19 (37%)
		zf-H2C2_2	277..301	CDD:290200	10/23 (43%)
		C2H2 Zn finger	292..312	CDD:275368	8/19 (42%)
ZNF98	NP_001092096.1	KRAB	13..73	CDD:214630	5/18 (28%)
		KRAB	13..52	CDD:279668
		COG5048	179..563	CDD:227381	67/223 (30%)
		C2H2 Zn finger	184..204	CDD:275368	4/27 (15%)
		zf-H2C2_2	196..220	CDD:290200	7/34 (21%)
		C2H2 Zn finger	212..232	CDD:275368	2/19 (11%)
		zf-H2C2_2	224..249	CDD:290200	2/24 (8%)
		C2H2 Zn finger	240..260	CDD:275368	5/19 (26%)
		zf-H2C2_2	252..277	CDD:290200	12/24 (50%)
		C2H2 Zn finger	268..288	CDD:275368	8/19 (42%)
		zf-H2C2_2	280..305	CDD:290200	11/24 (46%)
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		zf-H2C2_2	337..361	CDD:290200	10/23 (43%)
		zf-C2H2	350..372	CDD:278523	8/21 (38%)
		C2H2 Zn finger	352..372	CDD:275368	8/19 (42%)
		zf-H2C2_2	364..389	CDD:290200	5/16 (31%)
		C2H2 Zn finger	380..400	CDD:275368	97/353 (27%)
		C2H2 Zn finger	408..428	CDD:275368
		zf-H2C2_2	420..444	CDD:290200
		C2H2 Zn finger	436..456	CDD:275368
		zf-H2C2_2	449..473	CDD:290200
		C2H2 Zn finger	464..484	CDD:275368
		zf-H2C2_2	477..501	CDD:290200
		C2H2 Zn finger	492..512	CDD:275368
		zf-H2C2_2	504..529	CDD:290200
		C2H2 Zn finger	520..540	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910