DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4854 and ZNF560

DIOPT Version :9

Sequence 1:	NP_650860.1	Gene:	CG4854 / 42391	FlyBaseID:	FBgn0038766	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_689689.2	Gene:	ZNF560 / 147741	HGNCID:	26484	Length:	790	Species:	Homo sapiens

Alignment Length:	327	Identity:	88/327 - (26%)
Similarity:	125/327 - (38%)	Gaps:	86/327 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHTNVDSRDLKCRICLVQPKDESLMPTEPDFPDKIKRCTGVELSESPDWPNRICTSCALLLRAAL 65
            |.|:.:.|..:|:.|                                   .:..|.|:.|.:
Human   535 MRTHTEERLYQCKKC-----------------------------------GKAFTKCSYLTK--- 561

  Fly    66 KLRS-------LCQQTEKDLKEQKLQEINIEIVHDEQ--ETKK----KTESRDLSKN--EATGSD 115
            .||:       .|.:..|...|:.....::.....|:  |.||    .||..||:|:  ..||
Human   562 HLRTHAGEKPYECMKCGKAFTERSYLTKHLRRHSGEKPYECKKCGKAFTERSDLTKHLRRHTG-- 624

  Fly   116 SELEYEYLDSYDVTLESSEDVACSADELVSIEPAISAPEESVYSLSPKPVTFEDEDSGQAASFTC 180
             :..|||.|             |....:||..........:.|    ||             :.|
Human   625 -DKPYEYKD-------------CGKAFVVSSSLVDHLRTHTGY----KP-------------YKC 658

  Fly   181 NICNNVYSERVKLTNHMKVHSAKKPHECEICHKRFRQTPQLARHMNTHTGNRPYKCDYCDSRFAD 245
            |.|...||....||.|:|.|:|:|..||..|...||.:......:.|.|..:||||..|...|..
Human   659 NACEKAYSRSCVLTQHLKTHAAEKTSECNACGNSFRNSMCFHDRLKTLTKIKPYKCKDCGKAFTC 723

  Fly   246 PSTRIKHQRIHTNERPYKCEFCSRSFGYSNVLRVHLKTHTGERPFSCQYCQKSFSQLHHKNSHEK 310
            .|....|.||||.|:||||:.|.::|..|:....||:||.||:||.|..|.|:|:....:.:|.|
Human   724 HSDLTNHVRIHTGEKPYKCKECGKAFRTSSGRIQHLRTHMGEKPFECDQCGKAFASFSARIAHLK 788

  Fly   311 SH 312
            :|
Human   789 TH 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4854	NP_650860.1	zf-AD	12..>57	CDD:285071	3/44 (7%)
		C2H2 Zn finger	180..200	CDD:275368	9/19 (47%)
		zf-H2C2_2	193..217	CDD:290200	11/23 (48%)
		COG5048	201..>258	CDD:227381	20/56 (36%)
		C2H2 Zn finger	208..228	CDD:275368	4/19 (21%)
		zf-H2C2_2	221..244	CDD:290200	7/22 (32%)
		C2H2 Zn finger	236..256	CDD:275368	6/19 (32%)
		zf-H2C2_2	251..273	CDD:290200	12/21 (57%)
		C2H2 Zn finger	264..284	CDD:275368	6/19 (32%)
		zf-H2C2_2	277..301	CDD:290200	12/23 (52%)
		C2H2 Zn finger	292..312	CDD:275368	6/19 (32%)
ZNF560	NP_689689.2	KRAB	13..69	CDD:214630
		KRAB	13..50	CDD:279668
		KRAB	110..161	CDD:214630
		KRAB	110..149	CDD:279668
		C2H2 Zn finger	294..314	CDD:275368
		C2H2 Zn finger	323..342	CDD:275368
		COG5048	344..754	CDD:227381	73/289 (25%)
		C2H2 Zn finger	350..370	CDD:275368
		zf-H2C2_2	362..386	CDD:290200
		C2H2 Zn finger	378..398	CDD:275368
		C2H2 Zn finger	406..426	CDD:275368
		C2H2 Zn finger	434..454	CDD:275368
		C2H2 Zn finger	490..510	CDD:275368
		zf-H2C2_2	502..527	CDD:290200
		C2H2 Zn finger	518..538	CDD:275368	1/2 (50%)
		zf-H2C2_2	531..554	CDD:290200	5/53 (9%)
		C2H2 Zn finger	546..566	CDD:275368	7/57 (12%)
		zf-H2C2_2	558..582	CDD:290200	5/26 (19%)
		C2H2 Zn finger	574..594	CDD:275368	3/19 (16%)
		zf-H2C2_2	586..610	CDD:290200	4/23 (17%)
		zf-C2H2	600..622	CDD:278523	8/21 (38%)
		C2H2 Zn finger	602..622	CDD:275368	7/19 (37%)
		C2H2 Zn finger	630..650	CDD:275368	5/32 (16%)
		C2H2 Zn finger	658..678	CDD:275368	9/19 (47%)
		C2H2 Zn finger	714..734	CDD:275368	6/19 (32%)
		zf-H2C2_2	726..751	CDD:290200	12/24 (50%)
		C2H2 Zn finger	742..762	CDD:275368	6/19 (32%)
		zf-H2C2_2	757..779	CDD:290200	12/21 (57%)
		C2H2 Zn finger	770..790	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910