Protein Alignment CG4854 and ZNF573

DIOPT Version :10

• Sequence 1: NP_650860.1
• Gene: CG4854 / 42391
• FlyBaseID: FBgn0038766
• Length: 319
• Species: Drosophila melanogaster
• Sequence 2: NP_001166161.1
• Gene: ZNF573 / 126231
• HGNCID: 26420
• Length: 665
• Species: Homo sapiens
• Alignment Length: 361
• Identity: 87/361 - (24%)
• Similarity: 141/361 - (39%)
• Gaps: 78/361 - (21%)

  Fly    24 LMPTEPDFPDKIKRCTGVELSESPDWPNRICTSCALLLRAALKLRSL--CQQTEKDLKEQKLQEI 86
            ::..|..|.|...:|..:...|.|.:...|.::   .|::..|...|  |::.:|...    ...
Human    90 ILREETQFTDLDLQCEIISYIEVPTYETDISST---QLQSIYKREKLYECKKCQKKFS----SGY 147

  Fly    87 NIEIVHDEQETKKKTESRDLSKNEATG---------SDSELEYE-------YLDSYDVTLE---- 131
            .:.:.|.....::..|.::..||..:|         ...|..||       :...|.:|:.
Human   148 QLILHHRFHVIERPYECKECGKNFRSGYQLTLHQRFHTGEKPYECTECGKNFRSGYQLTVHQRFH 212

  Fly   132 -SSEDVACSADELVSIEPAISAPEESVYSLSPKPVTFEDEDSGQAAS-----------------F 178
             ..:...|.......|..:.....|.::: ..||  :|.::.|:|.|                 :
Human   213 TGEKTYECRQCGKAFIYASHIVQHERIHT-GGKP--YECQECGRAFSQGGHLRIHQRVHTGEKPY 274

  Fly   179 TCNICNNVYSERVKLTNHMKVHSAKKPHECEICHKRFRQTPQLARHMNTHTGNRPYKCDYCDSRF 243
            .|..|...:|.|..|..|.:.|:.:||:.||.|.|.||:..||..|...|||.:||:|..|...:
Human   275 KCKECGKTFSRRSNLVEHGQFHTDEKPYICEKCGKAFRRGHQLTVHQRVHTGKKPYECKECGKGY 339

  Fly   244 ADPSTRIKHQRIHTNERPYKCEFCSRSFG-YSNVLR---------------------------VH 280
            ...|..:.|||||...:||:|:.|.::|. |.|:.|                           .|
Human   340 TTASYFLLHQRIHKGGKPYECKECKKTFTLYRNLTRHQNIHTGEKLFECKQCGKTYTTGSKLFQH 404

  Fly   281 LKTHTGERPFSCQYCQKSFSQLHHKNSHEKSHKRTK 316
            .||||||:|:.|:.|.|:||...:...|:|.|...|
Human   405 QKTHTGEKPYECKECGKAFSLYGYLKQHQKIHTGMK 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4854	NP_650860.1	zf-AD	12..>57	CDD:214871	7/32 (22%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	201..>258	CDD:227381	24/56 (43%)
		C2H2 Zn finger	208..228	CDD:275368	9/19 (47%)
		zf-H2C2_2	221..244	CDD:463886	9/22 (41%)
		C2H2 Zn finger	236..256	CDD:275368	6/19 (32%)
		zf-H2C2_2	251..271	CDD:463886	9/19 (47%)
		C2H2 Zn finger	264..284	CDD:275368	8/47 (17%)
		C2H2 Zn finger	292..312	CDD:275368	7/19 (37%)
ZNF573	NP_001166161.1	KRAB	28..89	CDD:214630
		C2H2 Zn finger	136..156	CDD:275368	3/23 (13%)
		COG5048	160..521	CDD:227381	74/284 (26%)
		C2H2 Zn finger	164..184	CDD:275368	3/19 (16%)
		C2H2 Zn finger	192..212	CDD:275368	2/19 (11%)
		C2H2 Zn finger	220..240	CDD:275368	3/19 (16%)
		C2H2 Zn finger	248..268	CDD:275368	3/19 (16%)
		C2H2 Zn finger	276..292	CDD:275368	5/15 (33%)
		C2H2 Zn finger	304..324	CDD:275368	9/19 (47%)
		C2H2 Zn finger	332..352	CDD:275368	6/19 (32%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		C2H2 Zn finger	388..408	CDD:275368	2/19 (11%)
		C2H2 Zn finger	416..436	CDD:275368	7/19 (37%)
		COG5048	442..>664	CDD:227381
		C2H2 Zn finger	444..464	CDD:275368
		C2H2 Zn finger	472..492	CDD:275368
		C2H2 Zn finger	500..520	CDD:275368
		C2H2 Zn finger	528..548	CDD:275368
		C2H2 Zn finger	556..576	CDD:275368
		C2H2 Zn finger	584..604	CDD:275368
		C2H2 Zn finger	612..632	CDD:275368
		C2H2 Zn finger	640..660	CDD:275368