DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4854 and ZNF765-ZNF761

DIOPT Version :9

Sequence 1:	NP_650860.1	Gene:	CG4854 / 42391	FlyBaseID:	FBgn0038766	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_001337425.1	Gene:	ZNF765-ZNF761 / 110116772	-ID:	-	Length:	746	Species:	Homo sapiens

Alignment Length:	169	Identity:	63/169 - (37%)
Similarity:	88/169 - (52%)	Gaps:	17/169 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 FEDEDSGQAASF-----------------TCNICNNVYSERVKLTNHMKVHSAKKPHECEICHKR 214
            ::.|||.:|.||                 .||.|...:|....||.|.::|:.:||::||.|.|.
Human   578 YKCEDSDKAYSFKSNLEIHQKIHTEENPYKCNECGKTFSRTSSLTCHRRLHTGEKPYKCEECDKA 642

  Fly   215 FRQTPQLARHMNTHTGNRPYKCDYCDSRFADPSTRIKHQRIHTNERPYKCEFCSRSFGYSNVLRV 279
            ||....|..|...|||.:||||:.|...|:..|..|.|.|:||.|:||||..|.::|...:.|..
Human   643 FRVKSNLEGHRRIHTGEKPYKCNECGKTFSRKSYFICHHRLHTGEKPYKCNECGKNFSQKSSLIC 707

  Fly   280 HLKTHTGERPFSCQYCQKSFSQLHHKNSHEKSHKRTKEV 318
            |.:.||||:|:.|..|.|:|||..:...|.:.|...|:|
Human   708 HHRLHTGEKPYKCNECGKTFSQKSNLTCHRRLHTGEKQV 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4854	NP_650860.1	zf-AD	12..>57	CDD:285071
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		zf-H2C2_2	193..217	CDD:290200	11/23 (48%)
		COG5048	201..>258	CDD:227381	24/56 (43%)
		C2H2 Zn finger	208..228	CDD:275368	8/19 (42%)
		zf-H2C2_2	221..244	CDD:290200	10/22 (45%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		zf-H2C2_2	251..273	CDD:290200	11/21 (52%)
		C2H2 Zn finger	264..284	CDD:275368	5/19 (26%)
		zf-H2C2_2	277..301	CDD:290200	11/23 (48%)
		C2H2 Zn finger	292..312	CDD:275368	7/19 (37%)
ZNF765-ZNF761	NP_001337425.1	KRAB	7..48	CDD:307490
		C2H2 Zn finger	217..237	CDD:275368
		COG5048	242..617	CDD:227381	9/38 (24%)
		C2H2 Zn finger	244..264	CDD:275368
		C2H2 Zn finger	272..292	CDD:275368
		C2H2 Zn finger	300..320	CDD:275368
		C2H2 Zn finger	328..348	CDD:275368
		C2H2 Zn finger	356..376	CDD:275368
		C2H2 Zn finger	384..404	CDD:275368
		C2H2 Zn finger	412..432	CDD:275368
		C2H2 Zn finger	440..460	CDD:275368
		C2H2 Zn finger	468..488	CDD:275368
		C2H2 Zn finger	496..516	CDD:275368
		C2H2 Zn finger	524..544	CDD:275368
		C2H2 Zn finger	552..572	CDD:275368
		C2H2 Zn finger	580..600	CDD:275368	6/19 (32%)
		C2H2 Zn finger	608..628	CDD:275368	7/19 (37%)
		C2H2 Zn finger	636..656	CDD:275368	8/19 (42%)
		SFP1	<651..737	CDD:227516	36/85 (42%)
		C2H2 Zn finger	664..684	CDD:275368	7/19 (37%)
		C2H2 Zn finger	692..712	CDD:275368	5/19 (26%)
		C2H2 Zn finger	720..740	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000