DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4854 and ZNF730

DIOPT Version :9

Sequence 1:	NP_650860.1	Gene:	CG4854 / 42391	FlyBaseID:	FBgn0038766	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	XP_016881603.1	Gene:	ZNF730 / 100129543	HGNCID:	32470	Length:	514	Species:	Homo sapiens

Alignment Length:	294	Identity:	75/294 - (25%)
Similarity:	131/294 - (44%)	Gaps:	45/294 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 LCQQTEKDL-KEQKLQEINIEIVHDEQETKKKTESRDLSKNEATGSDSELEYEYLDSYDVTLESS 133
            :|....:|| .||.:::...|::. .|..|.:.|:..|.|......:.::..:..:.::..|.:|
Human    88 ICSHIAQDLWPEQGIKDYFQEVIL-RQYKKCRHENLLLRKGCKNVDEFKMHKKGYNRHNQCLTTS 151

  Fly   134 EDVACSADELVSIEPAIS-APEESVYSLSPKPV--------------------------TFEDED 171
            .......|:.|.:....| :....:...|.||.                          :::.|:
Human   152 HSKIFQCDKYVKVFHKFSNSNRHKIRHTSKKPFKCKECGKLFCILSHLAQHKKIHTGEKSYKCEE 216

  Fly   172 SGQAAS----------------FTCNICNNVYSERVKLTNHMKVHSAKKPHECEICHKRFRQTPQ 220
            .|:|.:                :.|..|...::.....|.|.::|:.:||::||.|.|.|.|:..
Human   217 YGKAFNESSNCTTHKRITEKKPYKCKECGKAFNWFSHFTTHKRIHTGEKPYQCEKCGKFFNQSTN 281

  Fly   221 LARHMNTHTGNRPYKCDYCDSRFADPSTRIKHQRIHTNERPYKCEFCSRSFGYSNVLRVHLKTHT 285
            |..|...|||.:||||:.|...|...|...:|::|||.|:|||||.|.::|.:|:.|..|.:.|.
Human   282 LTTHKRIHTGEKPYKCEECGKAFNQSSNLTEHKKIHTKEQPYKCEKCGKAFKWSSTLTKHKRIHN 346

  Fly   286 GERPFSCQYCQKSFSQLHHKNSHEKSHKRTKEVK 319
            ||:|:.|:.|.|:|::....|.|:.:|...|..|
Human   347 GEKPYKCEECGKAFNRSSTLNRHKITHTGGKPYK 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4854	NP_650860.1	zf-AD	12..>57	CDD:285071
		C2H2 Zn finger	180..200	CDD:275368	4/19 (21%)
		zf-H2C2_2	193..217	CDD:290200	10/23 (43%)
		COG5048	201..>258	CDD:227381	23/56 (41%)
		C2H2 Zn finger	208..228	CDD:275368	8/19 (42%)
		zf-H2C2_2	221..244	CDD:290200	10/22 (45%)
		C2H2 Zn finger	236..256	CDD:275368	5/19 (26%)
		zf-H2C2_2	251..273	CDD:290200	12/21 (57%)
		C2H2 Zn finger	264..284	CDD:275368	7/19 (37%)
		zf-H2C2_2	277..301	CDD:290200	10/23 (43%)
		C2H2 Zn finger	292..312	CDD:275368	6/19 (32%)
ZNF730	XP_016881603.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910