DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4424 and si:dkey-262g12.12

DIOPT Version :9

Sequence 1:	NP_650859.3	Gene:	CG4424 / 42390	FlyBaseID:	FBgn0038765	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	XP_017211312.1	Gene:	si:dkey-262g12.12 / 798048	ZFINID:	ZDB-GENE-161017-24	Length:	355	Species:	Danio rerio

Alignment Length:	271	Identity:	88/271 - (32%)
Similarity:	121/271 - (44%)	Gaps:	56/271 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 FLRE----------YVIK--DAVEQG---VVKEVVQQTRPSTPPPIETE---QLEPPEDEVLEEG 134
            |::|          :|:|  |..||.   |:||..|...       ||:   |.:..:|..|:|.
Zfish     3 FIKEESEDLKIEDTFVVKHEDPQEQTELMVMKEETQDRN-------ETQQKCQYDKHQDSTLDEK 60

  Fly   135 VWSTEDPIEETPHGPAEKERPTVLTVEMLPAPYPPPASTPPPAPAGAVKGKLHV----------C 189
              |.:...|..|.|    ||           .|..|..........|:  ::|:          |
Zfish    61 --SLKKKCERIPTG----ER-----------MYTCPQCEKSFRERQAL--EIHIRIHTGEKPFSC 106

  Fly   190 AICGNGYPRKSTLDTHMRRHNDERPYECEICHKSFHVNYQLKRHIRQHTGAKPYTCQYCQRNFAD 254
            ..||..:.:|..|..||..|..|:||.|..|.|||....||:.|.|.|||.||:.||.|.:.||.
Zfish   107 DHCGRRFSQKPNLKAHMSIHTAEKPYSCSECGKSFRAKKQLEGHTRVHTGEKPFACQQCGKRFAY 171

  Fly   255 RTSLVKHERTHRNERPYACKTCGKKFTYASVLKMHYKTHTGEKPHICQLCNKSFARIHNLVAHLQ 319
            :.:...|.|||..|:|:.|:.|||.||::..:|.|.:.||||||:.|..|.|:||...||..|.:
Zfish   172 QAAFRTHTRTHTGEKPFTCEQCGKSFTHSEYMKAHMRVHTGEKPYTCSQCGKTFAHRTNLYVHRR 236

  Fly   320 TQQHINDPRLT 330
            |  |..:...|
Zfish   237 T--HTGEKPFT 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4424	NP_650859.3	zf-AD	10..92	CDD:285071	2/13 (15%)
		C2H2 Zn finger	189..209	CDD:275368	7/19 (37%)
		DUF45	<204..281	CDD:302795	35/76 (46%)
		COG5048	210..>345	CDD:227381	53/121 (44%)
		C2H2 Zn finger	217..237	CDD:275368	9/19 (47%)
		C2H2 Zn finger	245..265	CDD:275368	7/19 (37%)
		zf-H2C2_2	257..282	CDD:290200	11/24 (46%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		zf-H2C2_2	286..310	CDD:290200	12/23 (52%)
		C2H2 Zn finger	301..320	CDD:275368	8/18 (44%)
si:dkey-262g12.12	XP_017211312.1	C2H2 Zn finger	78..98	CDD:275368	3/21 (14%)
		COG5048	<90..346	CDD:227381	63/160 (39%)
		C2H2 Zn finger	106..126	CDD:275368	7/19 (37%)
		C2H2 Zn finger	134..154	CDD:275368	9/19 (47%)
		C2H2 Zn finger	162..182	CDD:275368	7/19 (37%)
		C2H2 Zn finger	190..210	CDD:275368	8/19 (42%)
		C2H2 Zn finger	218..238	CDD:275368	9/21 (43%)
		C2H2 Zn finger	246..266	CDD:275368	88/271 (32%)
		C2H2 Zn finger	274..294	CDD:275368
		C2H2 Zn finger	302..322	CDD:275368
		C2H2 Zn finger	330..350	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910