DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4424 and ZNF142

DIOPT Version :9

Sequence 1:	NP_650859.3	Gene:	CG4424 / 42390	FlyBaseID:	FBgn0038765	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_001353219.1	Gene:	ZNF142 / 7701	HGNCID:	12927	Length:	1887	Species:	Homo sapiens

Alignment Length:	351	Identity:	94/351 - (26%)
Similarity:	135/351 - (38%)	Gaps:	115/351 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LCDKIESLSG------IQIRATAKEEVLPTRICLRCKAFLTLAHK----FRQICQRSNEFLREYV 93
            ||....||.|      .::...|.:|..|:|:.|.       .|:    |...||..:...||.|
Human  1536 LCPSPASLRGHTRKQHPRLECGACQEAFPSRLALD-------EHRRQQHFSHRCQLCDFAARERV 1593

  Fly    94 IKDAVEQGVVKEVVQQTRPST-------------PPPIE--------TEQLEPPEDEVLEEGV-- 135
                   |:||..::|...::             .||:.        ..||      ||:..|
Human  1594 -------GLVKHYLEQHEETSAAVAASDGDGDAGQPPLHCPFCDFTCRHQL------VLDHHVKG 1645

  Fly   136 -------------WSTEDPIEETPHG---PAEKERPTVLTVEMLPAPYPPPASTPPPAPAGAVKG 184
                         :||::..:.|.|.   ..||             ||
Human  1646 HGGTRLYKCTDCAYSTKNRQKITWHSRIHTGEK-------------PY----------------- 1680

  Fly   185 KLHVCAICGNGYPRKSTLDTHMRRHNDERPYECEIC-HKSFHVNYQLKRHIRQHTGAKPYTCQYC 248
              | |.:|.......|.|..|||.|.:||.|.|..| :|...|| |||.|:.:|||.|||.|..|
Human  1681 --H-CHLCPYACADPSRLKYHMRIHKEERKYLCPECGYKCKWVN-QLKYHMTKHTGLKPYQCPEC 1741

  Fly   249 Q--RNFADRTSLVKHERT-HRNERPYACKTCGKKFTYASVLKMHYKTHTGEKPHICQLCNKSF-- 308
            :  .|.||  :|..|:.| ||..|.:.|:.|||.|....:|:.|.:.|:..||::|.:|:::|
Human  1742 EYCTNRAD--ALRVHQETRHREARAFMCEQCGKAFKTRFLLRTHLRKHSEAKPYVCNVCHRAFRW 1804

  Fly   309 --ARIHNLVAHLQTQQHINDPRLTAY 332
              ...|:.:.|  |.:|....||..|
Human  1805 AAGLRHHALTH--TDRHPFFCRLCNY 1828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4424	NP_650859.3	zf-AD	10..92	CDD:285071	15/62 (24%)
		C2H2 Zn finger	189..209	CDD:275368	7/19 (37%)
		DUF45	<204..281	CDD:302795	37/80 (46%)
		COG5048	210..>345	CDD:227381	49/131 (37%)
		C2H2 Zn finger	217..237	CDD:275368	9/20 (45%)
		C2H2 Zn finger	245..265	CDD:275368	8/22 (36%)
		zf-H2C2_2	257..282	CDD:290200	11/25 (44%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		zf-H2C2_2	286..310	CDD:290200	8/27 (30%)
		C2H2 Zn finger	301..320	CDD:275368	5/22 (23%)
ZNF142	NP_001353219.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		C2H2 Zn finger	365..385	CDD:275368
		C2H2 Zn finger	393..413	CDD:275368
		C2H2 Zn finger	421..438	CDD:275368
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	545..566	CDD:275368
		C2H2 Zn finger	574..595	CDD:275368
		zf-H2C2_5	601..625	CDD:404746
		C2H2 Zn finger	603..623	CDD:275368
		C2H2 Zn finger	631..651	CDD:275368
		C2H2 Zn finger	659..679	CDD:275368
		C2H2 Zn finger	687..707	CDD:275368
		C2H2 Zn finger	714..731	CDD:275368
		PHA03247	928..>1219	CDD:223021
		C2H2 Zn finger	1306..1353	CDD:275368
		C2H2 Zn finger	1373..1394	CDD:275368
		C2H2 Zn finger	1402..1422	CDD:275368
		C2H2 Zn finger	1430..1451	CDD:275368
		C2H2 Zn finger	1626..1646	CDD:275368	5/25 (20%)
		C2H2 Zn finger	1654..1674	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1682..1702	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1710..1730	CDD:275368	9/20 (45%)
		zf-H2C2_2	1723..1747	CDD:404364	11/23 (48%)
		C2H2 Zn finger	1738..1759	CDD:275368	8/22 (36%)
		C2H2 Zn finger	1767..1787	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1795..1815	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1823..1843	CDD:275368	3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100