DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4424 and CG31388

DIOPT Version :9

Sequence 1:	NP_650859.3	Gene:	CG4424 / 42390	FlyBaseID:	FBgn0038765	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_650060.1	Gene:	CG31388 / 41355	FlyBaseID:	FBgn0051388	Length:	446	Species:	Drosophila melanogaster

Alignment Length:	434	Identity:	94/434 - (21%)
Similarity:	150/434 - (34%)	Gaps:	128/434 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MMTLCRTCLQDGE-AHMVSIFQTADDRLPGGVSLCDKIESLSGIQIRATAKEEVLPTRICLRCKA 70
            |..:||||.:..: |...::|.      |...|:..:||:|:.:|::...|   ||..:|..|:.
  Fly     1 MRYICRTCSRMADPAVAKNLFD------PSSSSVLRQIETLTNLQLKEDGK---LPRFMCQDCQH 56

  Fly    71 FLTLAHKFRQICQRSNEFLREYVIKDAVEQGVVKEVVQQTRPSTPPPIETEQLEP---------- 125
            .|.:|..||::|..:.|.|...:.:...|:...:.:.:|.....|.  |...|.|
  Fly    57 DLQIAIDFRRVCIEAQELLELQLRQVEKEEEAFESLAEQWLDDCPD--ELSNLSPVLQLNDRMDF 119

  Fly   126 ---PE------DEVLEEGVWSTEDPIEETPHGPAEKERPTVLTVEMLPAPYPPPASTPPPAP-AG 180
               ||      ||:......:|.:.:.......:.:..|.:.|...|...:.....:|...| :.
  Fly   120 IFDPEPQDKNTDELASIKTTTTTEYMNAYQSVASPQSSPELSTDSQLSNEHFDMGLSPESEPESE 184

  Fly   181 AVKG----------------------KLH-------------VCAICGNGYPRKSTLDTH----- 205
            |:..                      |||             ||..|..|:...:.|..|
  Fly   185 AIDNRDTSSSHTCSKCGLEFENVDELKLHKYHLHDIPPDTKFVCDHCDEGFRSAAALTRHCNMIN 249

  Fly   206 -------------------MRRHNDE--RP----YECEICHKSFHVNYQLKRHIRQHTGAKPYTC 245
                               :..|...  ||    :.|.||.|.....:.||.|:.:|.|.:.:.|
  Fly   250 LPLTHSCTKCKSQFHNHILLETHKQRCLRPPASQHVCHICGKHLTTAFNLKNHLVRHAGTRRHKC 314

  Fly   246 QYCQRNFADRTSLVKHERTHRNERPYACK-TCGKKFTYASVLKMHYKTHTGEKPHI--CQLCNKS 307
            ..|..:|.....|..|::||..||||.|: .|||.|.:.|...||.:.|......|  |:.|.||
  Fly   315 DQCSASFYTAAELCSHQKTHTTERPYICRYNCGKTFRFCSARSMHERVHMDASKRIYQCEYCPKS 379

  Fly   308 FA---------RIHNLV-------------------AHLQTQQH 323
            :.         :.|||.                   :||::..|
  Fly   380 YVTPSECRTHQKYHNLTRDHGCEICRISFKTAKHYRSHLKSNAH 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4424	NP_650859.3	zf-AD	10..92	CDD:285071	24/82 (29%)
		C2H2 Zn finger	189..209	CDD:275368	5/43 (12%)
		DUF45	<204..281	CDD:302795	28/107 (26%)
		COG5048	210..>345	CDD:227381	42/151 (28%)
		C2H2 Zn finger	217..237	CDD:275368	7/19 (37%)
		C2H2 Zn finger	245..265	CDD:275368	5/19 (26%)
		zf-H2C2_2	257..282	CDD:290200	13/25 (52%)
		C2H2 Zn finger	273..293	CDD:275368	8/20 (40%)
		zf-H2C2_2	286..310	CDD:290200	8/34 (24%)
		C2H2 Zn finger	301..320	CDD:275368	9/46 (20%)
CG31388	NP_650060.1	zf-AD	4..76	CDD:285071	23/80 (29%)
		C2H2 Zn finger	228..254	CDD:275368	5/25 (20%)
		C2H2 Zn finger	286..306	CDD:275368	7/19 (37%)
		C2H2 Zn finger	314..334	CDD:275368	5/19 (26%)
		C2H2 Zn finger	342..363	CDD:275368	8/20 (40%)
		C2H2 Zn finger	373..393	CDD:275368	4/19 (21%)
		C2H2 Zn finger	401..419	CDD:275368	1/17 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I1804
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960