DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4424 and CG8159

DIOPT Version :9

Sequence 1:	NP_650859.3	Gene:	CG4424 / 42390	FlyBaseID:	FBgn0038765	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_649823.2	Gene:	CG8159 / 41040	FlyBaseID:	FBgn0037619	Length:	399	Species:	Drosophila melanogaster

Alignment Length:	350	Identity:	98/350 - (28%)
Similarity:	162/350 - (46%)	Gaps:	56/350 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MMTLCRTCLQDGE-AHMVSIFQTADDRLPGGVSLCDKIESLSGIQIRATAKEEVLPTRICLRCKA 70
            :..:||.|....: :..:.:|.:      |...:..:|..|:|:.::.   |..||..:|..|:.
  Fly     2 LQNVCRVCASSTDNSKSLKLFNS------GACKVLQQINLLTGVLLQC---EPGLPDWMCETCQT 57

  Fly    71 FLTLAHKFRQICQRSNEFLREYVIKDAVEQGVVKEVV-----------QQTRPSTP-PPIET--- 120
            .|..|..||..|.||.:...|.::::  |:...:..|           :.|.|.|| .|:|.
  Fly    58 DLKSAISFRDRCLRSQKIFEESLVRN--EEDTFRSSVRRSARSQRQRHEDTAPKTPASPLEVMIK 120

  Fly   121 -EQLEPPEDEVLEEGVWSTEDPIEETPHGPAEKERPTVLTVEMLPAPYPPPASTPP-----PAPA 179
             |.|...::|  ::|:          .|..:..|....|.::.:.:......:|.|     ....
  Fly   121 LESLSNGDEE--DDGI----------DHLDSCNEADMELAIKAMSSSTEDDGTTSPVRLKRTRRR 173

  Fly   180 GAVKG-----------KLHVCAICGNGYPRKSTLDTHMRRHNDERPYECEICHKSFHVNYQLKRH 233
            |..||           .:..|..|||....||:.|.|:|:|:..||::||:|...|..:.:||.|
  Fly   174 GLKKGGKGENRTKVTLPVFFCDQCGNNITGKSSFDRHLRKHSGIRPFQCELCPARFLSSGELKGH 238

  Fly   234 IRQHTGAKPYTCQYCQRNFADRTSLVKHERTHRNERPYACKTCGKKFTYASVLKMHYKTHTGEKP 298
            ...|||.:.:.|:||.|.:.:.:..::|||||.|:||:.|..|||.||.:.:||.|...||||:.
  Fly   239 QVMHTGDRKFQCRYCDRTYVNYSGRLRHERTHTNDRPFICAQCGKSFTNSYILKNHMLIHTGERL 303

  Fly   299 HICQLCNKSFARIHNLVAHLQTQQH 323
            ..|:||::||||..:|..|.::..|
  Fly   304 FRCELCHRSFARPTHLKTHFRSNTH 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4424	NP_650859.3	zf-AD	10..92	CDD:285071	20/82 (24%)
		C2H2 Zn finger	189..209	CDD:275368	9/19 (47%)
		DUF45	<204..281	CDD:302795	31/76 (41%)
		COG5048	210..>345	CDD:227381	46/113 (41%)
		C2H2 Zn finger	217..237	CDD:275368	7/19 (37%)
		C2H2 Zn finger	245..265	CDD:275368	7/19 (37%)
		zf-H2C2_2	257..282	CDD:290200	13/24 (54%)
		C2H2 Zn finger	273..293	CDD:275368	9/19 (47%)
		zf-H2C2_2	286..310	CDD:290200	12/23 (52%)
		C2H2 Zn finger	301..320	CDD:275368	9/18 (50%)
CG8159	NP_649823.2	zf-AD	5..78	CDD:214871	20/81 (25%)
		C2H2 Zn finger	194..214	CDD:275368	9/19 (47%)
		COG5048	<197..322	CDD:227381	54/124 (44%)
		zf-H2C2_2	206..231	CDD:290200	10/24 (42%)
		C2H2 Zn finger	222..242	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		zf-H2C2_2	265..287	CDD:290200	13/21 (62%)
		C2H2 Zn finger	278..298	CDD:275368	9/19 (47%)
		zf-H2C2_2	291..315	CDD:290200	12/23 (52%)
		C2H2 Zn finger	306..328	CDD:275368	9/21 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960