DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4424 and CG2678

DIOPT Version :9

Sequence 1:	NP_650859.3	Gene:	CG4424 / 42390	FlyBaseID:	FBgn0038765	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_649750.1	Gene:	CG2678 / 40937	FlyBaseID:	FBgn0014931	Length:	434	Species:	Drosophila melanogaster

Alignment Length:	382	Identity:	96/382 - (25%)
Similarity:	153/382 - (40%)	Gaps:	80/382 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LCRTCLQDGEAHMVSIFQTADDRLPGGVSLCDKIE-SLSGIQIRATAKE----EVLPTRICLRCK 69
            :||||: |....:|.||....|      .:.|:.| |||.|..|.|.:.    ::||..||:.|.
  Fly     8 VCRTCM-DETGTLVDIFANVRD------PVLDEPEMSLSHILARCTERPVKRGDLLPQFICVSCV 65

  Fly    70 AFLTLAHKFR-QICQRSNEFLR--------EYVIKDAVEQGVVKEVV-QQTRPSTPPPIETEQL- 123
            ..:..|.:|: |..|....|.|        |..:..|...|...::: |:.:..:....:|:|:
  Fly    66 LAVQNAFRFKWQSEQSYQHFFRVLNQSGAPENQVHLAACNGDKNQIINQKMQLKSDRQQDTQQMT 130

  Fly   124 --EPPEDEV---------LEEGVWSTEDPIEETPHGPAEKERPTVLTVEMLPAPYPPPASTPPPA 177
              :.|:|::         |:||  :.:.|.|.....|.::...|....:|:|.  ....||....
  Fly   131 KTQKPDDDLSQKQTLQAKLQEG--NIDGPPESFTLHPRKRTCRTEEQADMIPK--EATRSTKMIC 191

  Fly   178 PA--------------GAVKGKLHV------CAICGNGYPRKSTLDTHMRRHNDERPYECEICHK 222
            .|              ...:.:.|:      |..|...|.:||.|..|:|.|..:..::|..|.|
  Fly   192 DADGYYNCPHCSKRFCSQTQLRTHITDLCNRCPYCPRTYMQKSNLKRHLRNHLSKPAHKCFHCSK 256

  Fly   223 SFHVNYQLKRHIRQHTGAKPYTCQYCQRNFADRTSLVKHERTHRNERPYACKTCGKK------FT 281
            :|.....||||:|.|....|.:|..|...|.:...|..|.|.|: :||.:.|:...|      ..
  Fly   257 AFMRKDHLKRHLRTHDSDGPLSCSQCSAVFIEHVQLEIHRREHK-QRPGSSKSESTKDPDSDDSD 320

  Fly   282 YASVLKMHYKTHT-----------GEKPHICQLCNKSFARIHNLVAHLQT---QQHI 324
            .|..||..:..:|           ..|| ||.:|.|.|:.::.|..|:.|   |.|:
  Fly   321 QAQDLKPKWTKNTFNGTCSIPPMLKPKP-ICDICQKKFSSVYALKRHMLTHNRQHHL 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4424	NP_650859.3	zf-AD	10..92	CDD:285071	28/95 (29%)
		C2H2 Zn finger	189..209	CDD:275368	8/19 (42%)
		DUF45	<204..281	CDD:302795	25/82 (30%)
		COG5048	210..>345	CDD:227381	38/135 (28%)
		C2H2 Zn finger	217..237	CDD:275368	9/19 (47%)
		C2H2 Zn finger	245..265	CDD:275368	6/19 (32%)
		zf-H2C2_2	257..282	CDD:290200	8/30 (27%)
		C2H2 Zn finger	273..293	CDD:275368	5/25 (20%)
		zf-H2C2_2	286..310	CDD:290200	10/34 (29%)
		C2H2 Zn finger	301..320	CDD:275368	6/18 (33%)
CG2678	NP_649750.1	zf-AD	8..85	CDD:214871	26/83 (31%)
		COG5048	220..>284	CDD:227381	22/63 (35%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		zf-C2H2	249..271	CDD:278523	9/21 (43%)
		C2H2 Zn finger	251..271	CDD:275368	9/19 (47%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..370	CDD:275368	6/19 (32%)
		C2H2 Zn finger	379..399	CDD:275368
		C2H2 Zn finger	406..427	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100