DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4424 and Neu2

DIOPT Version :9

Sequence 1:	NP_650859.3	Gene:	CG4424 / 42390	FlyBaseID:	FBgn0038765	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster

Alignment Length:	327	Identity:	94/327 - (28%)
Similarity:	129/327 - (39%)	Gaps:	69/327 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 MVSIFQTADDRLPGGVSLCDKIESLSGIQIRATAKEEVLPTRICLRCKAFLTLAHKFRQICQRSN 86
            |.|:|   |:....|:|:...|...:|.|:.   |.:.|...||..|......|....:..:||:
  Fly     1 MASVF---DESHEPGLSIAYIIYKCTGWQVE---KHDPLSNTICKSCLEDAQNAFDIIETYERSH 59

  Fly    87 EFLREYVIKDAVEQ-------GVVKEVVQQTRPSTPPPIETEQLEPPEDEVLEEGVWSTEDPIEE 144
            :|.|  .:||..|:       |..:||....|          .|:...|:| :.|   .|..|.|
  Fly    60 QFYR--FLKDVREEESENDGSGCSEEVEAAER----------DLQDGADDV-DSG---NEPDINE 108

  Fly   145 TPHGPAEKERPTVLTVEMLPAPYPPPASTPPPAPAGAVKGKLHVCAICGNGYPRKSTLDTHMRRH 209
            ......||                |..|                |:.|...:..||.|..|||.|
  Fly   109 CDIKAKEK----------------PGFS----------------CSHCPKSFQVKSNLKVHMRSH 141

  Fly   210 NDERPYECEICHKSFHVNYQLKRHIRQHTGAKPYTCQYCQRNFADRTSLVKHERTHRNERPYACK 274
            ..|||:.|.:|.|||..:..|:.|:|.|||.:|:.|.:|.|:|.....|..|.:.|.......|.
  Fly   142 TGERPFTCSLCPKSFGYSSGLQNHMRTHTGERPFQCSHCPRSFTAGHHLKAHIQMHERRGSLRCP 206

  Fly   275 TCGKKFTYASVLKMHYKTHTGEKPHICQLCNKSFARIHNLVAHLQTQQ-------HIN-DPRLTA 331
            .|.|.|..:.:||.|..|||.|....|..|:|||...|.|..|::..|       |.: |..|.|
  Fly   207 YCQKCFLTSLILKQHLATHTDETQFKCSQCSKSFQVEHELWMHMRVHQERLFTCGHCSKDFALHA 271

  Fly   332 YL 333
            ||
  Fly   272 YL 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4424	NP_650859.3	zf-AD	10..92	CDD:285071	19/69 (28%)
		C2H2 Zn finger	189..209	CDD:275368	8/19 (42%)
		DUF45	<204..281	CDD:302795	29/76 (38%)
		COG5048	210..>345	CDD:227381	48/132 (36%)
		C2H2 Zn finger	217..237	CDD:275368	8/19 (42%)
		C2H2 Zn finger	245..265	CDD:275368	6/19 (32%)
		zf-H2C2_2	257..282	CDD:290200	7/24 (29%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		zf-H2C2_2	286..310	CDD:290200	12/23 (52%)
		C2H2 Zn finger	301..320	CDD:275368	8/18 (44%)
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071	18/67 (27%)
		COG5048	<119..241	CDD:227381	47/137 (34%)
		C2H2 Zn finger	121..141	CDD:275368	8/19 (42%)
		zf-H2C2_2	133..158	CDD:290200	13/24 (54%)
		C2H2 Zn finger	149..169	CDD:275368	8/19 (42%)
		zf-H2C2_2	162..185	CDD:290200	10/22 (45%)
		C2H2 Zn finger	177..197	CDD:275368	6/19 (32%)
		C2H2 Zn finger	205..225	CDD:275368	7/19 (37%)
		zf-C2H2_8	206..286	CDD:292531	25/68 (37%)
		C2H2 Zn finger	233..253	CDD:275368	8/19 (42%)
		C2H2 Zn finger	260..297	CDD:275368	6/14 (43%)
		C2H2 Zn finger	303..323	CDD:275368
		C2H2 Zn finger	353..373	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100