DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4424 and CG17328

DIOPT Version :9

Sequence 1:	NP_650859.3	Gene:	CG4424 / 42390	FlyBaseID:	FBgn0038765	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_609786.2	Gene:	CG17328 / 34962	FlyBaseID:	FBgn0028895	Length:	413	Species:	Drosophila melanogaster

Alignment Length:	353	Identity:	99/353 - (28%)
Similarity:	144/353 - (40%)	Gaps:	66/353 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NMMTLCRTCLQDGEAHMVSIFQTADDRLPGGVSL--CDKIESLSGIQIRATAKEEVLPTRICLRC 68
            |:..:||.||:  |.|.|:...:.|..:...|.|  |.||.         ..|.:.||:.||..|
  Fly     4 NIHKICRVCLE--ELHPVTSIYSTDFAMMPSVMLMQCAKIR---------VFKTDGLPSVICNNC 57

  Fly    69 KAFLTLAHKFRQICQRSNEFLREYVIKDAVEQGVVKEVVQQTRPSTP-------PPIETEQLEPP 126
            ...|.:|..|:|.|:.|:..||:|:       |:::...|....:|.       |..::::.||.
  Fly    58 IYRLGVAFHFKQECENSDLRLRQYL-------GILESWRQDAATNTDFVEKPLLPQRDSDEEEPV 115

  Fly   127 EDEVLE-EGVWSTEDPIEETPHGPAEKERPTVLTVEMLPAPYPPPASTPPPAPAGAVKGKLHVCA 190
            :.:|.: ...:..:.|.|....||.             |.|..|                 |.|.
  Fly   116 DAKVSKRRSRYQRKPPEEHKKRGPK-------------PVPKMP-----------------HTCY 150

  Fly   191 ICGNGYPRKSTLDTHMRRHNDERPYECEICHKSFHVNYQLKRHIRQHTGAKPYTCQYCQRNFADR 255
            .|...:...:.|..|:|.|..|:||:|..|.:.|...|.||.|.|.|||.||:.|:.|.:.|:..
  Fly   151 ECHKSFKCIAQLTQHIRTHTGEKPYQCSFCIQRFAQKYNLKVHERTHTGDKPFQCEICSKQFSAL 215

  Fly   256 TSLVKHERTHRNERPYACKTCGKKFTYASVLKMHYKTHTGEKPHICQLCNKSFA-----RIHNLV 315
            .:...|::.|...|...|..|.|.|..|..|..|..||||.|.|.|.:|.|:|:     |.|.|.
  Fly   216 GNFQAHQKIHLGVRDQVCSLCQKGFYTAGDLSKHMITHTGIKNHHCDVCGKAFSRRRDMRTHKLK 280

  Fly   316 AH---LQTQQHINDPRLTAYLSTFKVGI 340
            .|   ..|...|.|......:.|..||:
  Fly   281 LHPLESSTNHDIVDDDDDEAIDTDPVGL 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4424	NP_650859.3	zf-AD	10..92	CDD:285071	27/83 (33%)
		C2H2 Zn finger	189..209	CDD:275368	5/19 (26%)
		DUF45	<204..281	CDD:302795	28/76 (37%)
		COG5048	210..>345	CDD:227381	49/139 (35%)
		C2H2 Zn finger	217..237	CDD:275368	8/19 (42%)
		C2H2 Zn finger	245..265	CDD:275368	4/19 (21%)
		zf-H2C2_2	257..282	CDD:290200	7/24 (29%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		zf-H2C2_2	286..310	CDD:290200	12/28 (43%)
		C2H2 Zn finger	301..320	CDD:275368	8/26 (31%)
CG17328	NP_609786.2	zf-AD	8..80	CDD:214871	26/82 (32%)
		COG5048	146..>211	CDD:227381	26/81 (32%)
		C2H2 Zn finger	149..169	CDD:275368	5/19 (26%)
		C2H2 Zn finger	177..197	CDD:275368	8/19 (42%)
		zf-H2C2_2	189..213	CDD:404364	11/23 (48%)
		C2H2 Zn finger	205..225	CDD:275368	4/19 (21%)
		C2H2 Zn finger	233..253	CDD:275368	7/19 (37%)
		zf-H2C2_2	245..270	CDD:404364	12/24 (50%)
		C2H2 Zn finger	261..282	CDD:275368	7/20 (35%)
		C2H2 Zn finger	318..338	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910