DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4424 and CG3032

DIOPT Version :9

Sequence 1:	NP_650859.3	Gene:	CG4424 / 42390	FlyBaseID:	FBgn0038765	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_001284974.1	Gene:	CG3032 / 31648	FlyBaseID:	FBgn0029928	Length:	431	Species:	Drosophila melanogaster

Alignment Length:	358	Identity:	89/358 - (24%)
Similarity:	143/358 - (39%)	Gaps:	87/358 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RLNMMTLCRTCLQDGEAHMVSIFQTADDRLPGGVSLCDKIESLSGIQI-----RATAKEEVLPTR 63
            |.::..||.|||...|...:.. :...|.:|    :..:::.|..|.:     ...|.::.||..
  Fly     7 RESVRELCCTCLLQLEKEPLKT-ELQSDEIP----ISQELQQLLNINLSQDVENQDADQQWLPNE 66

  Fly    64 ICLRCKAFLTLAHKFRQICQRSNEFLREYVIKDAVEQGVVKEVVQQTRPSTPPPIETEQLEPPED 128
            :||.|::.:....|||:......:.|.|.:.||..|                          |..
  Fly    67 LCLECRSAVQNFEKFRRKADECRKQLLEMLKKDPRE--------------------------PTF 105

  Fly   129 EVLEEGVWSTEDPIEETPHG--PAEKERPTVLTVEMLPAPYPPPASTP----PPAPAGAVKGKLH 187
            ||:.:|  ..||  :|:.||  |.|            |||.|.|...|    ..:|..:.:|..:
  Fly   106 EVVYDG--REED--QESLHGLEPPE------------PAPDPDPIDEPAIKSDKSPRKSFRGSRN 154

  Fly   188 V--CAICGNGYPRKSTLDTHMRR--HNDERPYECEICHKSFHVNYQLKRHIRQHTGAKP--YTCQ 246
            .  |::|...:..:.||..|:|:  ...:||::|:.|.|::.....|..|||:....|.  :.|.
  Fly   155 TLKCSVCRRSFAHQITLAAHIRKVHEGSKRPFQCDQCEKAYSFMGGLYTHIREVHAPKERRHPCD 219

  Fly   247 Y--CQRNFADRTSLVKHERTHRNER------PYACKTCGKKFTYASVLKMHYKTH---------- 293
            .  |:|.:..|.::.||:|...:.|      .:.|:.||..|..::.||.|.||.
  Fly   220 QPGCERIYTSRIAMQKHKRLKHSPRDRDALKKFICEQCGASFNQSANLKYHLKTKHPTEDEVAAR 284

  Fly   294 ---TGEKPHICQLCNKSFARIHNLVAHLQTQQH 323
               .||: |.|.:|.|.|...:.|..| ..|||
  Fly   285 EGGAGER-HFCDICQKEFHSRYTLKYH-TLQQH 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4424	NP_650859.3	zf-AD	10..92	CDD:285071	20/86 (23%)
		C2H2 Zn finger	189..209	CDD:275368	6/21 (29%)
		DUF45	<204..281	CDD:302795	23/88 (26%)
		COG5048	210..>345	CDD:227381	39/137 (28%)
		C2H2 Zn finger	217..237	CDD:275368	7/19 (37%)
		C2H2 Zn finger	245..265	CDD:275368	7/21 (33%)
		zf-H2C2_2	257..282	CDD:290200	8/30 (27%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		zf-H2C2_2	286..310	CDD:290200	12/36 (33%)
		C2H2 Zn finger	301..320	CDD:275368	6/18 (33%)
CG3032	NP_001284974.1	zf-AD	13..95	CDD:285071	20/86 (23%)
		C2H2 Zn finger	158..179	CDD:275368	6/20 (30%)
		C2H2 Zn finger	188..209	CDD:275368	7/20 (35%)
		C2H2 Zn finger	218..239	CDD:275368	6/20 (30%)
		C2H2 Zn finger	254..275	CDD:275368	9/20 (45%)
		C2H2 Zn finger	294..315	CDD:275368	7/21 (33%)
		C2H2 Zn finger	325..345	CDD:275368
		C2H2 Zn finger	352..373	CDD:275368
		C2H2 Zn finger	381..401	CDD:275368
		C2H2 Zn finger	409..429	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100