Protein Alignment psidin and MDM20

DIOPT Version :10

• Sequence 1: NP_650858.1
• Gene: psidin / 42389
• FlyBaseID: FBgn0243511
• Length: 948
• Species: Drosophila melanogaster
• Sequence 2: NP_014566.1
• Gene: MDM20 / 854079
• SGDID: S000005436
• Length: 796
• Species: Saccharomyces cerevisiae
• Alignment Length: 976
• Identity: 192/976 - (19%)
• Similarity: 352/976 - (36%)
• Gaps: 288/976 - (29%)

  Fly    27 NNRKALQESEKLLRKHPNLLCARALKGLSLLRL--GRYD------ESHGCLQTVAEEKPTDDSTL 83
            |.::...:..:|.::.||.|..:.|:.....:.  |::|      |.:|...|..   ..|..:|
Yeast    17 NFKQCYAKLGQLQKQFPNALYFKILETYVKFKQSPGKFDYNKLLEEPYGLKGTTI---TGDTRSL 78

  Fly    84 QVLSFCYREMEQLDKIVELYQHAVKQNPGNEELLAHLFISHVRVEDYKAQQAVALQLYKAQ---- 144
            :.|...:.|:.:.|:.:.:|:....:.| :.||..|.|:..:...:|......:|||.|..
Yeast    79 EFLHNFFVELGKYDEALHVYERGNFKFP-SYELSYHWFMKALEDSNYNQMSKASLQLAKYSDSGN 142

  Fly   145 -PKNAYYFWSVISVV----FQGIRGPESALPEKRKIYLGLAQRMVDKHIKEGKMETEQEAFLYLH 204
             ||.|||||:.||::    ||     |:.|.:.:||.|....|.....:|  ..:..||..:|
Yeast   143 LPKRAYYFWNAISILAVSRFQ-----ENTLSDPKKILLSRLARQSLLDLK--PFQNVQEIIVY-- 198

  Fly   205 ILKLQNKYQEAWEFLTGELCAKLYPGAPVSMKFEL-------LKELGNWRELNELLQQLLDADRD 262
            .|.|...:.::.| ::.|:.|..:.....|:...|       .|.|.:.::|.|:..:|::...|
Yeast   199 CLVLDELFPQSRE-ISEEIVAITFANFDTSVNLYLKNFILKHTKLLNSPQKLFEVCSKLIEKGLD 262

  Fly   263 RWDFYKEYIQSSFELLKLTPQGVENGDKDSLARCQEFLQRIIDSSERKKRGPYLARLELHQRMRA 327
            .::.....|.::::|.|         .||.       :::.||.:....|...||||:| ..|..
Yeast   263 DYELITNLIDAAYKLSK---------SKDE-------VKQWIDENLGDSRNTRLARLKL-DIMYT 310

  Fly   328 EQLPAEKLIGDFDEMVIEYFRLFGDKSCCTHDIALFLPSISMNQRQALASKLLLESGVTSTSLPK 392
            :.:....|        ..|...:.:|.||:.|:..:...|:::..:::.||.          .|:
Yeast   311 DSVSESSL--------SYYLSKYHNKPCCSIDLNHYSGHINIDMLKSIMSKY----------DPE 357

  Fly   393 NKEQLQKHLCALQISRMCGSHMDLPADHLLAFYTALKLHYEHGRTTFGKKLLATEMGPSDAYALL 457
            :|:.:  |.|.:....:.||      |.:        .:|...:.|..||.: |:......:.|
Yeast   358 DKDLI--HHCNILELGLIGS------DSI--------NNYNKFKGTLEKKSV-TDYSSCSTFLL- 404

  Fly   458 AANVMYDLSRREN------------------KSDHLFEALCLLQYVLRNSTSNFHVKLLSLKIYH 504
              .::.|..::.|                  |..|.|:.:|.|                 :.:|.
Yeast   405 --EIVKDKCKKTNPELKDVLLCITILENYQAKDPHNFDTMCWL-----------------IVLYM 450

  Fly   505 LFGCQVGAQEMYEYLDIKQIQLDSMGYVHCQLLALGGRFS-----GNRNVYDATLKFFTNSYKER 564
            ..|....|...:..|.||.:|.||:.|:      :..|||     ...:.|..|.....|.|...
Yeast   451 YLGLVPDAYFHFINLKIKNVQTDSLDYM------IFSRFSTLFPNKQSDFYSKTFHEHNNLYDTS 509

  Fly   565 L----EYIALTYRFCTFSKMEEFMNFKERLTNSLQYVACSVE----AQICDLVSCYGNITQNLSA 621
            |    .||.:.:...::||:...:..:::|..|......::|    :::|:  ...|::.|.|.
Yeast   510 LANLPRYIQVAFERNSYSKILGMLEMRDKLMKSYTRWTKTLENLQFSRLCN--DKRGHLLQKLH- 571

  Fly   622 YVAMSIEPAEDRIAWHEL--------SDNRDLGAIIRWDPLHEVDAAEERRESFDQ--------E 670
                     ||   |..|        |||||...:               .|:|.|        |
Yeast   572 ---------ED---WRSLEMTQSVSFSDNRDFSIL---------------DENFAQFLNRGKILE 609

  Fly   671 VEVLQVRSLMLRLFASFIDLYHGAGLKDSPAGAETATLELLRESWTGLFQRLRVMNYKPLAQKFL 735
            ...|...|:.|.|....|       ::..|.|.:|       |..:.|.::|..:|        |
Yeast   610 YANLNEESIFLTLIRELI-------IEALPNGEKT-------EQISALLKKLPSIN--------L 652

  Fly   736 VNLLPTRLHLLLDMPYERFFDDLAQLVLDLQSGSAKLAEQCKRVGDNVIATMELCVQTINESNES 800
            ..||...|..:....:..||:                                     |.|:|..
Yeast   653 EELLNNNLTEVESASFLIFFE-------------------------------------IYENNGK 680

  Fly   801 NGIDGLWKRRGQQQKVAASLEMLSLYAFLLSV-LNDKLQ-VSSKTKTKKKPVENKVDGPQPISEK 863
            |                    :..|.:.|:.| :|.|.. :.|.|...|......:|..:.|.:|
Yeast   681 N--------------------LHDLISRLMKVPINAKQNWMVSHTYLTKMATLKTLDSLKRIKDK 725

  Fly   864 ERSQMLQELMRQLKHKFEACDTAIRSW-KAPV-----LPRD-LSSFMSDMSLKPE----VEATLI 917
            |..::::..:::|:   ..||...:.: ||.|     |.:| ..:.:.::.:|.|    ::.:|:
Yeast   726 EIQKLIKNSLKELR---SCCDDVFKGYSKALVQAYEELKKDECGNLLKELDVKAENVKNIKNSLL 787

  Fly   918 G 918
            |
Yeast   788 G 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
psidin	NP_650858.1	TPR repeat	114..142	CDD:276809	8/27 (30%)
		NatB_MDM20	264..645	CDD:430834	80/419 (19%)
		Spy	1..>151	CDD:443119	31/136 (23%)
		TPR repeat	48..74	CDD:276809	6/33 (18%)
		TPR repeat	79..109	CDD:276809	6/29 (21%)
MDM20	NP_014566.1	NatB_MDM20	270..591	CDD:430834	80/413 (19%)