Protein Alignment psidin and NAA25

DIOPT Version :10

• Sequence 1: NP_650858.1
• Gene: psidin / 42389
• FlyBaseID: FBgn0243511
• Length: 948
• Species: Drosophila melanogaster
• Sequence 2: NP_079229.2
• Gene: NAA25 / 80018
• HGNCID: 25783
• Length: 972
• Species: Homo sapiens
• Alignment Length: 1006
• Identity: 326/1006 - (32%)
• Similarity: 512/1006 - (50%)
• Gaps: 118/1006 - (11%)

  Fly    13 ERRLRPVYDNLEVGNNRKALQESEKLLRKHPNLLCARALKGLSLLRLGRYDESHGCLQTVAEEKP 77
            :|||||:||.|:.|||:.|:|:::|||:||.:|.||:.||.:.|.|.|:.:|:....|.||..:|
Human    12 DRRLRPIYDYLDNGNNKMAIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFTLAQEVAALEP 76

  Fly    78 TDDSTLQVLSFCYREMEQLDKIVELYQHAVKQNPGNEELLAHLFISHVRVEDYKAQQAVALQLYK 142
            |||::||.|:..||||.:.:.:.:||:.|||:.|.:||..:|||:::.||.:||..|...:.|||
Human    77 TDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLFMAYARVGEYKKMQQAGMALYK 141

  Fly   143 AQPKNAYYFWSVISVVFQGIRGPESALPEKRKIYLGLAQRMVDKHIKEGKMETEQEAFLYLHILK 207
            ..|||.||||||:|::.|.|...:..|  .:.::|.||:|||:|.:||.|:|.|.|..||..||:
Human   142 IVPKNPYYFWSVMSLIMQSISAQDENL--SKTMFLPLAERMVEKMVKEDKIEAEAEVELYYMILE 204

  Fly   208 LQNKYQEAWEFLTGELCAKLYPGAPVSMK----FELLKELGNWRELNELLQQLLDADRDRWDFYK 268
            ...|||||.:.:.|:|..||  .:.:..:    ..:.|:|..|.|.|.|.::||..:.|.|.||.
Human   205 RLGKYQEALDVIRGKLGEKL--TSEIQSRENKCMAMYKKLSRWPECNALSRRLLLKNSDDWQFYL 267

  Fly   269 EYIQSSFELLKLTPQGVENGDKD-------SLARCQEFLQ-RIIDSSE--RKKRGPYLARLELHQ 323
            .|..|.|.|::........|:..       |..:..:|:: ||.:.|:  |..|||:||:|||.:
Human   268 TYFDSVFRLIEEAWSPPAEGEHSLEGEVHYSAEKAVKFIEDRITEESKSSRHLRGPHLAKLELIR 332

  Fly   324 RMRAEQLPAEKLIGDFDEMVIEYFRLFGDKSCCTHDIALFLPSISMNQRQALASKLLLESGVTST 388
            |:|::....|..:||.:|::.:||:.||||.||..|:.:|:..:...|.....::||   ||...
Human   333 RLRSQGCNDEYKLGDPEELMFQYFKKFGDKPCCFTDLKVFVDLLPATQCTKFINQLL---GVVPL 394

  Fly   389 S--------LPKNKEQLQKHLCALQISRMCGSHMDLPADHLLAFYTALKLHYEHGRTTFGKKLLA 445
            |        ||.:...||:|||.:|::|:.|.:..:..:..|:....|.|.|:|| ..|||..|.
Human   395 STPTEDKLALPADIRALQQHLCVVQLTRLLGLYHTMDKNQKLSVVRELMLRYQHG-LEFGKTCLK 458

  Fly   446 TEMGPSDAYALLAANVMYDLSRRENKSDHLFEALCLLQYVLRNSTSNFHVKLLSLKIYHLFGCQV 510
            ||:..||.|.|||.:.:.|:.|.......:::||.||:..|.:|.||...|||.::||    |.:
Human   459 TELQFSDYYCLLAVHALIDVWRETGDETTVWQALTLLEEGLTHSPSNAQFKLLLVRIY----CML 519

  Fly   511 GAQE----MYEYLDIKQIQLDSMGYVHCQLLALGGRFSGNRNVYDATLKFFTNSYKERLEYIALT 571
            ||.|    :|..||.|.||.|::||:..:.....|:::......:..|:||.::.|:..|||...
Human   520 GAFEPVVDLYSSLDAKHIQHDTIGYLLTRYAESLGQYAAASQSCNFALRFFHSNQKDTSEYIIQA 584

  Fly   572 YRFCTFSKMEEFMNFKERLTNSLQYVACSVEAQICDLVSCYGNITQNLSAYV-AMSIEPAEDRIA 635
            |::..|.|:.||:.|:.||.|||.:.....|..:.||: ...||:.:|:..: :|::.|.||.|.
Human   585 YKYGAFEKIPEFIAFRNRLNNSLHFAQVRTERMLLDLL-LEANISTSLAESIKSMNLRPEEDDIP 648

  Fly   636 WHELSDNRDLGAIIRWDPLHEVDAAEERRE-SFDQEVEVLQVRSLMLRLFASFIDLYHGAGLKDS 699
            |.:|.|||||.....||| .:.|.:||.:: |.::|...|::|||.|||.:....|.|....|:|
Human   649 WEDLRDNRDLNVFFSWDP-KDRDVSEEHKKLSLEEETLWLRIRSLTLRLISGLPSLNHPVEPKNS 712

  Fly   700 PAGAETAT------LELLRESWTGLFQRLRVMNYKPLAQKFLVNLLPTRL--------------- 743
            ...||...      |.||.:......:..:....|.:...|| ..:|||:
Human   713 EKTAENGVSSRIDILRLLLQQLEATLETGKRFIEKDIQYPFL-GPVPTRMGGFFNSGCSQCQISS 776

  Fly   744 -HLLLDMPYE---RFFDDLAQLVLDLQSGSAKLAEQCKRVGDNVIATMELCVQTINESNESNGID 804
             :|:.|: ||   ...:|..::...:::....|.:|.|.|                 .::..| |
Human   777 FYLVNDI-YELDTSGLEDTMEIQERIENSFKSLLDQLKDV-----------------FSKCKG-D 822

  Fly   805 GLWKRRGQQQKVAASLEMLSLYAFLLSVLNDKLQVSS------------KTKTKKKPVENKVDGP 857
            .|..:.|..:.....||.|..:...:||:   |.|||            ..|.|||..|..:..|
Human   823 LLEVKDGNLKTHPTLLENLVFFVETISVI---LWVSSYCESVLRPYKLNLQKKKKKKKETSIIMP 884

  Fly   858 QPI--SEKERSQMLQELMRQLKHKFEACDTAIRSWKAPVLPRDLSSFMSDMSLKPE---VEATLI 917
             |:  |.::....||.|:..:....:..:|.:.:.|...|      .:.|.||.||   ...|:.
Human   885 -PVFTSFQDYVTGLQTLISNVVDHIKGLETHLIALKLEEL------ILEDTSLSPEERKFSKTVQ 942

  Fly   918 GDVSATFKDSHELMVTELRNLLKDKIRMVAK 948
            |.|.:::  .|.|:  |:..|||.::....|
Human   943 GKVQSSY--LHSLL--EMGELLKKRLETTKK 969

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
psidin	NP_650858.1	TPR repeat	114..142	CDD:276809	11/27 (41%)
		NatB_MDM20	264..645	CDD:430834	135/403 (33%)
		Spy	1..>151	CDD:443119	64/137 (47%)
		TPR repeat	48..74	CDD:276809	9/25 (36%)
		TPR repeat	79..109	CDD:276809	13/29 (45%)
NAA25	NP_079229.2	TPR 1	11..44		18/31 (58%)
		BepA	21..146	CDD:443813	54/124 (44%)
		TPR 2	45..78		12/32 (38%)
		TPR repeat	47..73	CDD:276809	9/25 (36%)
		TPR repeat	78..108	CDD:276809	13/29 (45%)
		TPR 3	79..112		14/32 (44%)
		TPR 4	114..146		13/31 (42%)
		NatB_MDM20	263..658	CDD:430834	135/403 (33%)