DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment psidin and naa25

DIOPT Version :9

Sequence 1:	NP_650858.1	Gene:	psidin / 42389	FlyBaseID:	FBgn0243511	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	NP_595632.1	Gene:	naa25 / 2540082	PomBaseID:	SPBC1215.02c	Length:	811	Species:	Schizosaccharomyces pombe

Alignment Length:	916	Identity:	190/916 - (20%)
Similarity:	354/916 - (38%)	Gaps:	220/916 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LSLLRLGRYDESHGCLQTVAEEKPTDDSTLQVLSFCYREMEQLDKIVE--LYQHAVKQNPGNEE- 115
            |||.:.||..|:...|:.:   |.|..::|::|.......:...|..|  ::.....|..|.:|
pombe    16 LSLAQAGRGPEALALLEPL---KSTPINSLELLDIIQAVYDDQKKGEESFVFWEKFLQTYGKQEK 77

  Fly   116 -LLAHLFISHVRVEDYKAQQAVALQLYKAQPKNAYYFWSVISVVFQGIRGPESALPEKRKIYLGL 179
             |||: |.:.:|::....|:..|::|.|..|...:..| |||.::...:..|:.:.::      |
pombe    78 NLLAY-FKASIRIKSLSHQRKAAVELQKNFPSRKHTLW-VISSLYLLSKKSENEVEQR------L 134

  Fly   180 AQRMVDKHIK------EGKMETEQEAFLYLHILKLQNK---------YQEAWEFLTGELCAKLYP 229
            .:.:.:|..|      .|.:::.:|..|||.:|.|...         :|:|..|:..:....|
pombe   135 LKALAEKTAKLIFEKPTGYIDSCEEFHLYLDVLLLVGDKDRALDALIHQDADRFVDADADLLL-- 197

  Fly   230 GAPVSMKFELLKELGNWRELNELLQQLLDADRDRWDFYKEYIQSSFELLKLTPQGVENGDKDSLA 294
                 .|.|||.....|..|......|.......|...|..:.|:            :.|...|.
pombe   198 -----RKLELLASCARWDSLFTFSLSLFQTGNTDWKVCKALLDSA------------SNDDSKLV 245

  Fly   295 RCQEFLQRIIDSSERKKRGPYLARLELHQRMRAEQLPAEKLIGDFDEMVIEYFRLFGDKSCCTHD 359
            ..::.:.:.:.:|. .||..:|..:|...|...|         :.:..::.|.:....|.....|
pombe   246 PLKDCILKALSTSS-TKRNLHLLWIEASARFFPE---------EHESALLGYIKKLYMKPIVFED 300

  Fly   360 IALFLPSISMN-QRQALASKLLLESGVTSTSLPKNKEQLQKHLCALQISRMCGSHMDLPADHLLA 423
            :..:|..:::: |.:.|.:..|.:.|.::.|  :..::|...:..|:|             |.|.
pombe   301 LRPYLLKLNVDAQHRLLDAFKLADLGESNES--QKVDKLYAEVLLLKI-------------HFLL 350

  Fly   424 F--YTALK---------LHYEHGRTTFGKKLLATEMGPS-DAYALLAANVMY------DLSRREN 470
            |  :||..         :.:|.| .:..|.||.|:.... :|..|...:::|      ||...|
pombe   351 FESFTAESVVDYVRRCFVAFEKG-LSLSKGLLPTDFTHGYEALLLAVHSLIYMWEGNKDLKPAE- 413

  Fly   471 KSDHLFEALCLLQYVLRNSTSNFHVKLLSLKIYHLF-GCQVGAQEMYEYLDIKQIQLDSMGYVHC 534
            |...:|:|:|||:..:..|..|||:||..:::|.|. |....|.::|:.:.|||||.|::.:
pombe   414 KQALIFDAICLLEKGITYSQHNFHLKLPLIRLYLLLDGGFPAAAKVYDTMSIKQIQNDTLDH--- 475

  Fly   535 QLLALGGRF---SGNRNVYDATLKFFTNSYKERLEYIALTYRFCTFSKMEEFMNFKERLTNSLQY 596
            .||.....:   |...:..:::||.:.::..|..|.|::.|....:|::|:..||:.||.:|...
pombe   476 YLLTRATTYYPSSVTSHYINSSLKIYGSNEFETPEMISMAYEDGAYSQIEDMRNFRSRLDHSTWK 540

  Fly   597 VACSVEAQICDLVSCYGNITQNLSAYVAMSIEPAEDRIAWHELSDNRDLGAIIRWDPLHEVDAAE 661
            ....||......::.:....|    |:.....|          .|||||...        .|...
pombe   541 SISLVERARIHYLTAFKPPKQ----YLPKCSSP----------KDNRDLKVF--------ADYGS 583

  Fly   662 ERRESFDQEVEVLQVRSLMLRLFASFIDLYHGAGLKDSPAGAETATLELLRESWTGLFQRLRVMN 726
            ::..:.::                         .|::||   :..||      |.    .|.|:.
pombe   584 DKLPTVEE-------------------------SLRNSP---KPDTL------WI----HLTVIG 610

  Fly   727 YKPLAQKFLVN-------LLPTRLHLLL---DMPYERFFDDLAQLVLDLQSG--SAKLAEQCKRV 779
            :. |.|..:||       |....:.:|.   |:..:...:::..:.|.:|.|  |.|:     :.
pombe   611 HS-LVQDSIVNGDFEKAVLSAKEMEVLCENNDLSKQLTSEEIVHMKLLIQLGLLSVKV-----KN 669

  Fly   780 GD---NVIATMELCVQTINESNESNGIDGLWKRRGQQQKVAASLEMLSLYAFLLSVLNDKLQVSS 841
            ||   :...|:|..:::.:..|                  :..|..|:.|.   .::||.:...:
pombe   670 GDYENSSFETIENLIESFDYEN------------------STPLSQLTKYT---EIINDLITCLN 713

  Fly   842 K-----TKTKKKPVENKVDGPQPISEKERSQMLQELMRQLKHKFEACDTAIRSWKAPVLPRDLSS 901
            .     :.||||....:....:.||    |..|..:....|||.:|.    |.:.:.:|.   :|
pombe   714 SFLYHVSATKKKEFTRQYQLLKNIS----SNKLGSISGITKHKKKAA----RKYVSELLS---NS 767

  Fly   902 FMSDMS 907
            ::|::|
pombe   768 WLSNLS 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
psidin	NP_650858.1	TPR_12	42..108	CDD:290160	13/55 (24%)
		TPR repeat	48..74	CDD:276809	7/19 (37%)
		TPR repeat	79..109	CDD:276809	4/31 (13%)
		TPR repeat	114..142	CDD:276809	9/29 (31%)
		NatB_MDM20	264..642	CDD:286836	85/400 (21%)
naa25	NP_595632.1	NatB_MDM20	227..580	CDD:286836	90/416 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	61	1.000	Domainoid score	I2992
eggNOG	1	0.900	-	-		E1_KOG2053
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6891
Inparanoid	1	1.050	89	1.000	Inparanoid score	I1761
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004730
OrthoInspector	1	1.000	-	-		oto100655
orthoMCL	1	0.900	-	-		OOG6_102465
Panther	1	1.100	-	-	LDO	PTHR22767
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2662
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.890