Protein Alignment psidin and Naa25

DIOPT Version :10

• Sequence 1: NP_650858.1
• Gene: psidin / 42389
• FlyBaseID: FBgn0243511
• Length: 948
• Species: Drosophila melanogaster
• Sequence 2: NP_766310.2
• Gene: Naa25 / 231713
• MGIID: 2442563
• Length: 972
• Species: Mus musculus
• Alignment Length: 1003
• Identity: 318/1003 - (31%)
• Similarity: 514/1003 - (51%)
• Gaps: 112/1003 - (11%)

  Fly    13 ERRLRPVYDNLEVGNNRKALQESEKLLRKHPNLLCARALKGLSLLRLGRYDESHGCLQTVAEEKP 77
            :|||||:||.|:.|||:.|:|:::|||:||.:|.||:.||.:.|.|.|:.:|:....|.||..:|
Mouse    12 DRRLRPIYDYLDNGNNKMAIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFTLAQEVAALEP 76

  Fly    78 TDDSTLQVLSFCYREMEQLDKIVELYQHAVKQNPGNEELLAHLFISHVRVEDYKAQQAVALQLYK 142
            |||::||.|:..||||.:.:.:.:||:.|||:.|.:||..:|||:::.||.:||..|...:.|||
Mouse    77 TDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLFMAYARVGEYKKMQQAGMALYK 141

  Fly   143 AQPKNAYYFWSVISVVFQGIRGPESALPEKRKIYLGLAQRMVDKHIKEGKMETEQEAFLYLHILK 207
            ..|||.||||||:|::.|.|...:..|  .:.::|.||:|||:|.:||.|:|.|.|..||..||:
Mouse   142 IVPKNPYYFWSVMSLIMQSISARDENL--SKTMFLPLAERMVEKMVKEDKIEAEAEVELYYMILE 204

  Fly   208 LQNKYQEAWEFLTGELCAKLYPGAPVSMK----FELLKELGNWRELNELLQQLLDADRDRWDFYK 268
            ...|||||.:.:.|:|..||  .:.:..:    ..:.|:|..|.|.|.|.::||..:.|.|.||.
Mouse   205 RLGKYQEALDVIRGKLGEKL--TSEIQSRENKCMAMYKKLSKWPECNALSRRLLLKNSDDWQFYL 267

  Fly   269 EYIQSSFELLK--LTPQGVENGDKDSLARCQ-----EFLQ-RIIDSSE--RKKRGPYLARLELHQ 323
            .|..|.|.|::  .||........:....|.     :|:: ||.::|:  |..|||:||:|||.:
Mouse   268 TYFDSVFRLIEEAWTPPAEGEHSLEGEVHCSAEDAVKFIEDRITEASQSSRHVRGPHLAKLELIR 332

  Fly   324 RMRAEQLPAEKLIGDFDEMVIEYFRLFGDKSCCTHDIALFLPSISMNQRQALASKLLLESGVTST 388
            |:|::....|..:||.:|::.:||:.||||.||..|:.:|:..:...|.....::||   ||...
Mouse   333 RLRSQGCNDEYKLGDPEELMFQYFKKFGDKPCCFTDLKVFVDLLPAAQCTQFINQLL---GVVPL 394

  Fly   389 S--------LPKNKEQLQKHLCALQISRMCGSHMDLPADHLLAFYTALKLHYEHGRTTFGKKLLA 445
            |        ||.:...||:|||.:|::|:.|.:..:.....|.....|.|.|:|| ..||:..|.
Mouse   395 STPTEDKLALPADIRGLQQHLCVVQLTRLLGLYHSMDKSQKLDVVKELMLRYQHG-LEFGRSCLK 458

  Fly   446 TEMGPSDAYALLAANVMYDLSRRENKSDHLFEALCLLQYVLRNSTSNFHVKLLSLKIYHLFGCQV 510
            ||:..||.|.|||.:|:.|:.|...:...:::||.||:..|.:|.||...|||.::||.:.|...
Mouse   459 TELQFSDYYCLLAVHVLIDVWREAGEETAVWQALTLLEEGLTHSPSNAQFKLLLVRIYCVLGAFE 523

  Fly   511 GAQEMYEYLDIKQIQLDSMGYVHCQLLALGGRFSGNRNVYDATLKFFTNSYKERLEYIALTYRFC 575
            ...::|..||.|.||.|::||:..:..|..|:::......:..|:||.::.|:..|||...|::.
Mouse   524 PVVDLYSSLDAKHIQHDTIGYLLTRYAASLGQYAAASQSCNFALRFFHSNQKDTSEYIIQAYKYG 588

  Fly   576 TFSKMEEFMNFKERLTNSLQYVACSVEAQICDLVSCYGNITQNLSAYV-AMSIEPAEDRIAWHEL 639
            .|.|:.||:.|:.||.|||.:.....|..:.||: ...||:.:|:..: :|::.|.||.:.|.:|
Mouse   589 AFEKIPEFIAFRNRLNNSLHFAQVRTERMLLDLL-LEANISISLAESIKSMNLRPEEDDVPWEDL 652

  Fly   640 SDNRDLGAIIRWDPLHEVDAAEERRESFDQEVEVLQVRSLMLRLFASFIDLYHGAGLKDSPAGAE 704
            .|||||.....|||.....:.|.::.|.::|...|::|||.|||.:....|.|....|:|...:|
Mouse   653 RDNRDLDVFFSWDPKDRNVSEEHKKLSLEEETMWLRIRSLTLRLISGLPSLTHPVEPKNSEKMSE 717

  Fly   705 ---TATLELLRESWTGLFQRLRV-------MNYKPLAQKFLVNLLPTRL---------------- 743
               ::.:::||.    |.|:|.|       ...|.:...|| ..:|||:
Mouse   718 NGVSSRIDILRL----LLQQLEVAVETGKRFIEKEIQYPFL-GPVPTRMGRFFSSGCCQCQVQSF 777

  Fly   744 HLLLDMPYERFFDDLAQLVLDLQSGSAKLAEQCKRVGDNVIATMEL-------CVQTINESNESN 801
            ||:.|| ||          || .||.....:..:|:.:::.:.:||       |...:.|..:
Mouse   778 HLVSDM-YE----------LD-TSGLEGTVDIQERIENSLASLLELLKGVFSTCKGDLLEVTD-- 828

  Fly   802 GIDGLWKRRGQQQKVAASLEMLSLYAFLLSVLNDKLQVSSKTKTKKKPVENKVDGPQPISEKERS 866
                     |..:...|.||.|..:...:||:   |.|||..::..:|.:..:...:. .:||.|
Mouse   829 ---------GNVKTQPAVLENLVFFVETISVI---LWVSSYCESVLRPYKLNIQKKKK-KKKETS 880

  Fly   867 QMLQELMRQLKHKFEACDTA-------IRSWKAPVLPRDLSSF-MSDMSLKPE---VEATLIGDV 920
            .::..:....:.......|.       |:..:|.::...|... :.:.|:..|   ...|:.|.|
Mouse   881 IIMPPIFTSFQDYVTGLQTVISNAVDHIKGLEAHLIALRLEELTLEETSISTEERKFSKTVQGKV 945

  Fly   921 SATFKDSHELMVTELRNLLKDKIRMVAK 948
            .:::  .|.|:  |...||:.::....|
Mouse   946 QSSY--LHSLL--ETGELLRKRLETTKK 969

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
psidin	NP_650858.1	TPR repeat	114..142	CDD:276809	11/27 (41%)
		NatB_MDM20	264..645	CDD:430834	133/399 (33%)
		Spy	1..>151	CDD:443119	64/137 (47%)
		TPR repeat	48..74	CDD:276809	9/25 (36%)
		TPR repeat	79..109	CDD:276809	13/29 (45%)
Naa25	NP_766310.2	TPR 1	11..44		18/31 (58%)
		BepA	21..146	CDD:443813	54/124 (44%)
		TPR 2	45..78		12/32 (38%)
		TPR repeat	47..73	CDD:276809	9/25 (36%)
		TPR repeat	78..108	CDD:276809	13/29 (45%)
		TPR 3	79..112		14/32 (44%)
		TPR 4	114..146		13/31 (42%)
		NatB_MDM20	263..658	CDD:430834	133/399 (33%)