DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MED25 and PFT1

DIOPT Version :9

Sequence 1:	NP_650854.1	Gene:	MED25 / 42385	FlyBaseID:	FBgn0038760	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_173925.3	Gene:	PFT1 / 839141	AraportID:	AT1G25540	Length:	836	Species:	Arabidopsis thaliana

Alignment Length:	970	Identity:	228/970 - (23%)
Similarity:	340/970 - (35%)	Gaps:	265/970 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EVDQIPLADVVFVIEGSAINGAYINELKTNYILPTLEHFTTGSID-EREYLIAERFATLYGIVVY 65
            ||.|:     :.|.||:|..|.|...:.::|:...:..|....:: ||..:.....:    :|::
plant     4 EVKQL-----IVVAEGTAALGPYWQTIVSDYLEKIIRSFCGSELNGERNPVSTVELS----LVIF 59

  Fly    66 RTAANLLEPVCSTYGPFLQPQKVMETIERLPLVGGGMESCAHMAEGFAAAHGCFDDISERRQLLD 130
            .:..:....:....|........:..:..:...|||....| .|||.|.|...|...|.:.|  .
plant    60 NSHGSYCACLVQRSGWTRDVDIFLHWLSSIQFGGGGFNEVA-TAEGLAEALMMFSPPSGQAQ--P 121

  Fly   131 QTSVQRHCILICNSPPYQMPT------------TESWKYPGKS----CEQLAALFNERKINLSII 179
            ...::||||||..|.|:.:||            .|:.....:|    .|.:|:.|.:..::||::
plant   122 SNDLKRHCILITASNPHILPTPVYRPRLQNVERNENGDAQAESRLSDAETVASYFAKCSVSLSVV 186

  Fly   180 APRKMPVLFKLFMKADGDQPIT--SKNYAKNIRHLVLLKGYSLKERAPSPNSMAAQMAAPNAAQA 242
            .|:::|.:..|:.....:|...  |.:.|||..:|||:          |.|.:.|..|..::|..
plant   187 CPKQLPTIRALYNAGKPNQQSADLSIDTAKNTFYLVLI----------SENFVEACAALSHSATN 241

  Fly   243 TVQQQQQQQQNQAGQQQQGQGMPMDTTPAQQQQQQQQQQQQQQQQGNPQQQVMNMN-TMQQQQP- 305
            ..|.|...:.::|   .....:|:                    .|.|...|.:.| .:|.:||
plant   242 LPQTQSPVKVDRA---TVAPSIPV--------------------TGQPPAPVSSANGPIQNRQPV 283

  Fly   306 --GPNP----------------------------PAGLLNPQQQQQLLQQQQQNQFVSNQMQNQN 340
              ||.|                            ||....|..|........|: .|||.....:
plant   284 SVGPVPTATVKVEPSTVTSMAPVPSFPHIPAVARPATQAIPSIQTSSASPVSQD-MVSNAENAPD 347

  Fly   341 FQQNVGPGQNRWMYPNQPGQARPPFMQG-------------AGNVGGVGQGGGMQQNPNSALISR 392
            .:..|..|....:....||.|....:..             ||....|||........|......
plant   348 IKPVVVSGMTPPLRTGPPGGANVNLLNNLSQVRQVMSSAALAGAASSVGQSAVAMHMSNMISTGM 412

  Fly   393 INAPPPNQTVTSLQQQQQQQAQQQQQQQQQAQQQQ----------------------QQRMQMLS 435
            ..:.||:|||.|..||..............||..|                      .|.||.::
plant   413 ATSLPPSQTVFSTGQQGITSMAGSGALMGSAQTGQSPGPNNAFSPQTTSNVASNLGVSQPMQGMN 477

  Fly   436 QQQMLNHQQLQQQQQLAQQQQQQQQGQQQQQVNPNAGNNMMPASNAGNMSNPQQQQQQVGQQSNP 500
            |.   :|.....|..:: ..|....|..|..|:...| .|||....|..:....||......|.|
plant   478 QG---SHSGAMMQGGIS-MNQNMMSGLGQGNVSSGTG-GMMPTPGVGQQAQSGIQQLGGSNSSAP 537

  Fly   501 QQQGNPQQQQQGNSQQEQASLREKIWTGVLEWSEKPKSDQQKIPHTLQCTVCTNIKDGEP----- 560
            ..|   ..|....:.|...|...|:|.|.|       |.|               :.|:|
plant   538 NMQ---LSQPSSGAMQTSQSKYVKVWEGNL-------SGQ---------------RQGQPVLITR 577

  Fly   561 ----------EIKAENWPPKL-LMQLMPKHLVGNIGGQFLKDSKMVVFRPTPGEALDSLAKMMTS 614
                      :..|.||||.: :::|:.:..:.|  .|::..:..:|||           .|...
plant   578 LEGYRSASASDSLAANWPPTMQIVRLISQDHMNN--KQYVGKADFLVFR-----------AMSQH 629

  Fly   615 GYAGCVHFSSI--------------PNSPACDLKVLILLYTPDRNAFLGFIPNNQAMFVERLRKV 665
            |:.|.:....:              .:..||  :::.:|:..|...|...|||.|....::|.:
plant   630 GFLGQLQDKKLCAVIQLPSQTLLLSVSDKAC--RLIGMLFPGDMVVFKPQIPNQQQQQQQQLHQ- 691

  Fly   666 IQQKQHGNMQQQQQQQQMMQQQGKSPMELQQQQQQQQQQQQMQQDNSQQQHYNQFQLNMQMGGGG 730
             ||:|...:||||||||.:||| :.| :|||||||.|||||.|...||.||:.|.|...|
plant   692 -QQQQQQQIQQQQQQQQHLQQQ-QMP-QLQQQQQQHQQQQQQQHQLSQLQHHQQQQQQQQ----- 748

  Fly   731 PGGGPGPGPGGMPMQQNQMQMNMM------QQQRMPLGVGVGVGVGPGGVPNPNLQQQ---LQQV 786
                         .||.|.|:..:      |||..||.               .:|||   |.|:
plant   749 -------------QQQQQHQLTQLQHHHQQQQQASPLN---------------QMQQQTSPLNQM 785

  Fly   787 APNVAAMQQQQAQQQQQRMVRPMMSNNNPGLRQLLQHQTTPGNQFRPQMGGQNPNQMGAG 846
            ....:.:.|.|.|||.|:||.        |.:...|   .||...:...||| ||..|||
plant   786 QQQTSPLNQMQQQQQPQQMVM--------GGQAFAQ---APGRSQQGGGGGQ-PNMPGAG 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED25	NP_650854.1	Med25_VWA	4..218	CDD:288159	53/232 (23%)
MED25	NP_650854.1	Med25	524..671	CDD:288130	34/176 (19%)
PFT1	NP_173925.3	vWFA	8..226	CDD:294047	52/239 (22%)
PFT1	NP_173925.3	Forkhead_N	404..506	CDD:254796	21/105 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	49	1.000	Domainoid score	I4450
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004644
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12433
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.100