Protein Alignment MED25 and Med25

DIOPT Version :9

• Sequence 1: NP_650854.1
• Gene: MED25 / 42385
• FlyBaseID: FBgn0038760
• Length: 863
• Species: Drosophila melanogaster
• Sequence 2: XP_017167855.1
• Gene: Med25 / 75613
• MGIID: 1922863
• Length: 861
• Species: Mus musculus
• Alignment Length: 900
• Identity: 249/900 - (27%)
• Similarity: 359/900 - (39%)
• Gaps: 259/900 - (28%)

  Fly     8 LADVVFVIEGSAINGAYINELKTNYILPTLEHFTTGSIDEREYLIAERFATLYGIVVYRTAANLL 72
            :|||||||||:|..|.|..||:.:|:||.:|:|..|...|.:: ..:...|.|.:||:.|.....
Mouse    74 VADVVFVIEGTANLGPYFEELRKHYLLPAIEYFNGGPPAETDF-GGDYGGTQYSLVVFNTVDCAP 137

  Fly    73 EPVCSTYGPFLQPQKVMETIERLPLVGGGMESCAHMAEGFAAAHGCFDDISERRQLLDQTSVQRH 137
            |.....:.|.....:.:..::.:..:|||.|||:.:|||.:.|...|||..:.|:.:.||  .|.
Mouse   138 ESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQT--HRV 200

  Fly   138 CILICNSPPYQMPTTESWKYPGKSCEQLAALFNERKINLSIIAPRKMPVLFKLFMKADG------ 196
            |:||||||||.:|..||..|.|.:.|.|.....||.|:.||::|||:|.|..||.||..
Mouse   201 CLLICNSPPYLLPAVESTTYSGCTTESLVQKIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEP 265

  Fly   197 -DQPITSKNYAKNIRHLVLLKGY-----------SLKER-----APSPNSMAAQMAAPNAAQATV 244
             .||   .:.:::.||:||::|.           ||:.:     .|:|.|.|...|||..|...|
Mouse   266 LQQP---ADVSQDPRHMVLVRGLVLPVGGSSTSGSLQTKQAVPLPPAPASAATLSAAPPQALPPV 327

  Fly   245 QQQQQQQQNQAGQQQQGQGMPMDTTPAQQQQQQQQQQQQQQQQG-NPQQQVMNMNTMQQQQPGPN 308
            ..|.|              :|.:.:.||...|...:..:.|:.| .|  :...:|.:||..||..
Mouse   328 PPQYQ--------------VPGNLSAAQVAAQNAVEAAKSQKAGLGP--RFSPINPLQQAAPGVG 376

  Fly   309 PPAGLLNPQQQQQLLQQQQQNQFVSNQMQNQNFQQNVGPGQNRWMYPNQPGQARPPFMQGAGNVG 373
            ||                              |.|...|.    :.|..||..:||
Mouse   377 PP------------------------------FSQAPAPP----LAPVPPGAPKPP--------- 398

  Fly   374 GVGQGGGMQQNPNS--ALISRINAPPPNQTVTSLQQQQQQQAQQQQQQQQQAQQQQQQRMQMLSQ 436
                       |.|  :|:|.: ||.|
Mouse   399 -----------PASQPSLVSTV-APGP-------------------------------------- 413

  Fly   437 QQMLNHQQLQQQQQLAQQQQQQQQGQQQQQVNPNAGNNMMPASNAGNMSNPQQQQQQVGQQSNPQ 501
                         .||...|......|...|.|            |.::.|     ...|...|.
Mouse   414 -------------VLAAPAQPGAPSLQAGTVTP------------GGVNGP-----SAAQLGGPA 448

  Fly   502 QQGNPQQQQQGNSQQEQASLREKIWTGVLEWSEKPK----SDQQKIPHTLQCTVCTNIKDGEPEI 562
            ..|           |:..|.:...|:|||||.||||    ....|:..:|.|.|..|  .|| .:
Mouse   449 LGG-----------QQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVN--HGE-NL 499

  Fly   563 KAENWPPKLLMQLMPKHLVGNIGGQFLKDSKMVVFRPTPG--EALDSLAKMMTSGYAGCVHFSSI 625
            |.|.||.||:|||:|:.|:..:|..| ::|:||.|..|..  |:|..|.::|.:|:||||||
Mouse   500 KTEQWPQKLIMQLIPQQLLTTLGPLF-RNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHF--- 560

  Fly   626 PNSPACDLKVLILLYTPDRNAFLGFIPNNQAMFVERLRKVIQQKQHGNMQQQQQQQQ-------- 682
            |::..|:::||:|||:..:..|:|.||.:|:.||..:|:||  ..|..:|||:.:||
Mouse   561 PHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVI--TNHKQVQQQKLEQQRGMGAQQA 623

  Fly   683 ------MMQQQGKSPMELQQQQQQQQQQQ---QMQQDNSQQQHYNQFQLNMQMGGGGPGGGPGPG 738
                  ::::|.:.|..|.|.:..|.|.|   .......|.|.....|.......|.||..|||.
Mouse   624 PPVLGPILEEQARPPQNLLQLRAPQPQPQGAVGASAATGQPQPQGATQAPTGAPQGPPGAAPGPP 688

  Fly   739 PGGMPMQQNQMQMNMMQQQRMPLGVGVGVGVGPGGVPNPNLQQQLQQVAPNVAAMQQQQAQQQQQ 803
            |.| |:.:.|                     .||.  ||.|:..|...||....:...||....
Mouse   689 PSG-PILRPQ---------------------NPGA--NPQLRSLLLNPAPPQTGVPPPQASLHH- 728

  Fly   804 RMVRPMMSNNNPGLRQLLQHQTTPGNQFRPQMGGQN---------PNQMGAGGPM 849
              ::|      ||...||....:.|   :||:|.|.         |.|:....|:
Mouse   729 --LQP------PGAPTLLPPHQSMG---QPQLGPQLLHPPPAQSWPTQLPQRAPL 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED25	NP_650854.1	Med25_VWA	4..218	CDD:288159	81/216 (38%)
		Med25	524..671	CDD:288130	63/152 (41%)
Med25	XP_017167855.1	Med25_VWA	74..285	CDD:371441	81/216 (38%)
		Med25_SD1	287..443	CDD:371429	50/294 (17%)
		Med25	460..605	CDD:371427	63/153 (41%)
		PAT1	<620..>779	CDD:370676	43/188 (23%)
		Med25_NR-box	717..>773	CDD:371432	15/67 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833054
Domainoid	1	1.000	138	1.000	Domainoid score	I4838
eggNOG	1	0.900	-	-		E1_28J9E
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4353
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47953
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004644
OrthoInspector	1	1.000	-	-		mtm8853
orthoMCL	1	0.900	-	-		OOG6_108352
Panther	1	1.100	-	-	LDO	PTHR12433
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4646
SonicParanoid	1	1.000	-	-		X6592
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.880