Protein Alignment MED25 and PTOV1

DIOPT Version :9

• Sequence 1: NP_650854.1
• Gene: MED25 / 42385
• FlyBaseID: FBgn0038760
• Length: 863
• Species: Drosophila melanogaster
• Sequence 2: XP_024307309.1
• Gene: PTOV1 / 53635
• HGNCID: 9632
• Length: 455
• Species: Homo sapiens
• Alignment Length: 483
• Identity: 115/483 - (23%)
• Similarity: 188/483 - (38%)
• Gaps: 146/483 - (30%)

  Fly   263 GMPMDTTPAQQQQQQQQQQQQQQQQGNPQQQVMNMNTMQQQQPGPNPPAGLLNPQQQQQLLQQQQ 327
            |.|:..||.:                      :......|..|.|..|||..:|.
Human    27 GAPVPATPPE----------------------VVARASSQDSPAPERPAGPPSPH---------- 59

  Fly   328 QNQFVSNQMQNQNFQQNVGPGQNRWMYPNQPGQARPP--FMQGA---GNVGGVGQG------GGM 381
                                        :.|.:|..|  .::||   |.:|.:|..      ||:
Human    60 ----------------------------SAPARAPLPRAALEGARVFGALGPIGPSSPGLTLGGL 96

  Fly   382 ---QQNPNSALIS-------RINAPPPNQTVTSLQQQQQQQAQQQQQQQQQAQQQQQQR-MQMLS 435
               :...::.|::       :....|.:.:...|::....||...|.:..:..|..|:. ||::.
Human    97 AVSEHRLSNKLLAWSGVLEWQEKRRPYSDSTAKLKRTLPCQAYVNQGENLETDQWPQKLIMQLIP 161

  Fly   436 QQQMLNHQQLQQQQQLAQ-----QQQQQQQGQQQQQVNPNAG----------------------- 472
            ||.:.....|.:..||||     :.....:|..:...|..||
Human   162 QQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRIMGNGFAGCMLFPHISPCEVRVLMLLYSSKK 226

  Fly   473 ---NNMMPASNAGNMSNPQQ----QQQQVGQ---QSNPQQQGNPQQQQQGNSQQEQASLREKIWT 527
               ..::|...:|.:|..:|    ::|.||.   .|.|.|..|.               :...|:
Human   227 KIFMGLIPYDQSGFVSAIRQVITTRKQAVGPGGVNSGPVQIVNN---------------KFLAWS 276

  Fly   528 GVLEWSEKPKSDQQKIPHTLQCTVCTNIKDGEPEIKAENWPPKLLMQLMPKHLVGNIGGQFLKDS 592
            ||:||.|.......:....|...|..|  .|| .::.|.||.||.|||:|:.|:..:...| ::|
Human   277 GVMEWQEPRPEPNSRSKRWLPSHVYVN--QGE-ILRTEQWPRKLYMQLIPQQLLTTLVPLF-RNS 337

  Fly   593 KMVVFRPTPG-EALDSLAKMMTSGYAGCVHFSSIPNSPACDLKVLILLYTPDRNAFLGFIPNNQA 656
            ::|.|..|.. |.|.||.::|.:|:|||||||   ...:|:::||:|||:.::..|:|.||::|.
Human   338 RLVQFHFTKDLETLKSLCRIMDNGFAGCVHFS---YKASCEIRVLMLLYSSEKKIFIGLIPHDQG 399

  Fly   657 MFVERLRKVI---QQKQHGNMQQQQQQQ 681
            .||..:|:||   ||....|::|:|||:
Human   400 NFVNGIRRVIANQQQVLQRNLEQEQQQR 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED25	NP_650854.1	Med25_VWA	4..218	CDD:288159
		Med25	524..671	CDD:288130	57/150 (38%)
PTOV1	XP_024307309.1	DNA_pol3_delta2	<1..156	CDD:331068	29/188 (15%)
		Med25	108..253	CDD:314224	24/144 (17%)
		Med25	273..414	CDD:314224	55/147 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142935
Domainoid	1	1.000	110	1.000	Domainoid score	I6293
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004644
OrthoInspector	1	1.000	-	-		mtm8619
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12433
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.940