DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MED25 and CG13609

DIOPT Version :9

Sequence 1:	NP_650854.1	Gene:	MED25 / 42385	FlyBaseID:	FBgn0038760	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_651233.1	Gene:	CG13609 / 42883	FlyBaseID:	FBgn0039170	Length:	364	Species:	Drosophila melanogaster

Alignment Length:	259	Identity:	93/259 - (35%)
Similarity:	141/259 - (54%)	Gaps:	41/259 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 QGNPQQQQQGNSQQEQASLREKIWTGVLEWSEKPKSDQQKIPHTLQCTVCTNIKDGEPEIKAENW 567
            |..|:..:.|:|       :|.||:|.|||.:....||.|..||:||.:|:.:|:|:|||..|||
  Fly    31 QKEPENPENGDS-------KETIWSGELEWEDAQILDQPKTLHTVQCKICSMVKEGQPEINTENW 88

  Fly   568 PPKLLMQLMPKHLVGNIGGQFLKDSKMVVFRPTPGEALDSLAKMMTSGYAGCVHFSSIPNSPACD 632
            |.||..||:||.::|.||.|||||::|||||.:.||.|:.|...|:||:|||:||   |::|.|:
  Fly    89 PNKLKTQLIPKKVLGKIGEQFLKDARMVVFRSSQGEVLNLLITAMSSGFAGCIHF---PSNPNCN 150

  Fly   633 LKVLILLYTPDRNAFLGFIPNNQAMFVERLRKVIQQKQHGNMQQQQQQQQMMQQQG-KSPMELQQ 696
            :|.|||:|:.|..|.:||||||:..|.|||::::|..:              ::.| |:|.:.|.
  Fly   151 IKALILIYSRDHQALVGFIPNNEDSFSERLQEILQGAK--------------RKPGVKTPKQPQP 201

  Fly   697 QQQQQQQQQ----------------QMQQDNSQQQHYNQFQLNMQMGGGGPGGGPGPGPGGMPM 744
            ::....::.                |...:.....|..:..:.:.:..|.||......|..|||
  Fly   202 EEPPPVEEDAIINELLWTGSLNWSTQASLEEPSISHKLECSVYIAIKNGDPGISAEDWPTDMPM 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED25	NP_650854.1	Med25_VWA	4..218	CDD:288159
MED25	NP_650854.1	Med25	524..671	CDD:288130	75/146 (51%)
CG13609	NP_651233.1	Med25	45..189	CDD:288130	75/160 (47%)
CG13609	NP_651233.1	Med25	216..358	CDD:288130	9/50 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458024
Domainoid	1	1.000	115	1.000	Domainoid score	I5970
eggNOG	1	0.900	-	-		E1_28J9E
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004644
OrthoInspector	1	1.000	-	-		otm26484
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12433
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.840