DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MED25 and med25

DIOPT Version :9

Sequence 1:	NP_650854.1	Gene:	MED25 / 42385	FlyBaseID:	FBgn0038760	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	XP_005163994.1	Gene:	med25 / 406793	ZFINID:	ZDB-GENE-040426-2850	Length:	725	Species:	Danio rerio

Alignment Length:	883	Identity:	253/883 - (28%)
Similarity:	364/883 - (41%)	Gaps:	258/883 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LADVVFVIEGSAINGAYINELKTNYILPTLEHFTTGSIDEREYLIAERFATLYGIVVYRTAANLL 72
            ::||||||||:|..|.|...|:.||||||:|:|..|...|.:: ..:...|.||:||:.|.....
Zfish    12 VSDVVFVIEGTANLGPYFESLRNNYILPTIEYFNGGPPAETDF-GGDYGGTQYGLVVFNTVDCAP 75

  Fly    73 EPVCSTYGPFLQPQKVMETIERLPLVGGGMESCAHMAEGFAAAHGCFDDISERRQLLDQTSVQRH 137
            |.....:.|.....:.:..|:.:..:|||.|||:.:|||.:.|...|||..:.|:.:.||  .:.
Zfish    76 ESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQT--HKV 138

  Fly   138 CILICNSPPYQMPTTESWKYPGKSCEQLAALFNERKINLSIIAPRKMPVLFKLFMKAD---GDQP 199
            |:|:||||||.:|..||..|.|.:.:.|..:..:|.|:.|:|||||:|.|..||.:|.   |...
Zfish   139 CVLLCNSPPYLLPAVESVSYTGCTADSLVQIIRDRGIHFSVIAPRKLPALRSLFERASSVAGPPE 203

  Fly   200 ITSKNYAKNIRHLVLLKGYSLKERAPSPNSMAAQMAAPNAAQATVQQQQQQQQNQAGQQQQGQGM 264
            .:..:|:::..|:||::|.:|.             .||.                      |..:
Zfish   204 SSHPDYSQDPFHMVLVRGIALP-------------VAPG----------------------GGSV 233

  Fly   265 PMDTTPAQQQQQQQQQQQQQQQQGNPQQQVMN----MNTMQQQQPGPNPPAGLLNPQQQQQL--- 322
            |:...|....|.....|       ||...|.:    |||.|      |......:...|:.|
Zfish   234 PVSLKPVLPPQSLPVNQ-------NPLVPVASTAPQMNTFQ------NVSLHAAHDAAQKALEEA 285

  Fly   323 LQQQQQNQFVSNQMQNQNFQQNVGPGQNRWMYPNQPGQ-ARPPFMQGAGNVGGVGQGGGMQQNPN 386
            ..|||:|:|                           || :.|||.|..     |...||   .|:
Zfish   286 ANQQQKNRF---------------------------GQISTPPFSQSP-----VLPPGG---KPS 315

  Fly   387 SALISRINAPPPNQTVTSLQQQQQQQAQQQQQQQQQAQQQQQQRMQMLSQQQMLNHQQLQQQQQL 451
            .:.::.::.|                                                     .|
Zfish   316 LSTVTTVSPP-----------------------------------------------------VL 327

  Fly   452 AQQQQQQQQGQQQQQVNPNAGNNMMPASNAGNMSNPQQQQQQVGQQSN--PQQQG------NPQQ 508
            .|||...||.|||.|| |..|   :||.   |...||..|||...|..  |.|.|      .|..
Zfish   328 TQQQVPPQQPQQQTQV-PQPG---LPAV---NQQPPQASQQQPNNQQTPPPTQPGMAAVPAPPPG 385

  Fly   509 QQQGNSQQEQASLREKIWTGVLEWSEKPKSDQQ----KIPHTLQCTVCTNIKDGEPEIKAENWPP 569
            .|||.:.:..|      |:|||||.||||:...    |:..:|.|.|  .:..|| .:..:.||.
Zfish   386 AQQGVANKVVA------WSGVLEWQEKPKASSMDSNTKLTRSLPCQV--QVSQGE-NLNTDQWPQ 441

  Fly   570 KLLMQLMPKHLVGNIGGQFLKDSKMV--VFRPTPGEALDSLAKMMTSGYAGCVHFSSIPNSPACD 632
            ||:|||:|:.|:..:|..| ::|:||  :|.....|:|..|.::||||:||||||   |:|..|:
Zfish   442 KLIMQLIPQQLLTTLGPLF-RNSRMVQFLFTNKDMESLKGLFRIMTSGFAGCVHF---PHSAPCE 502

  Fly   633 LKVLILLYTPDRNAFLGFIPNNQAMFVERLRKVIQQKQHGNMQQQQQQQ--QMMQQQ-------- 687
            ::||:|||:..:..|:|.|||:|:.||..:|:||  ..|..:|||:..|  |:...|
Zfish   503 VRVLMLLYSSRKRIFMGLIPNDQSGFVNGIRQVI--TNHKQVQQQRSMQPGQVQPNQNFLNRPPG 565

  Fly   688 ------GKSPME-------------LQQQQQQQQQQQQMQQDNSQQQHY-----NQFQLNMQMGG 728
                  |..|.:             |.:.||:|....:.....:||...     ||.|...|..|
Zfish   566 PIPVTHGNVPQQSVVVGLPSVSQVTLMEDQQRQNNMLRAAATGNQQAPVTGAPPNQVQGQAQAPG 630

  Fly   729 GG------PGGGPGPGPGGMPMQQNQMQMNMMQQQRMPLGVGVGVGVGPGGVPNPNLQQQLQQVA 787
            ||      ||..|            |::..::.||  |.|       |..|:...:..||:...|
Zfish   631 GGMLRLQNPGANP------------QLRSLLLSQQ--PQG-------GMQGMQGMHPIQQMVHAA 674

  Fly   788 PNVAAMQQQQAQQQQQRMVRPMM--------SNNNPGL 817
            |...|..|.|.:|..|   .|:|        ...|||:
Zfish   675 PGGGAQMQPQWRQPHQ---GPLMVPTGPRGPVTQNPGM 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED25	NP_650854.1	Med25_VWA	4..218	CDD:288159	79/212 (37%)
MED25	NP_650854.1	Med25	524..671	CDD:288130	63/152 (41%)
med25	XP_005163994.1	Med25_VWA	10..222	CDD:288159	79/212 (37%)
		Med25_SD1	224..>325	CDD:288132	33/183 (18%)
		Med25	395..541	CDD:288130	65/160 (41%)
		Med25_NR-box	<668..725	CDD:288141	14/45 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588146
Domainoid	1	1.000	145	1.000	Domainoid score	I4527
eggNOG	1	0.900	-	-		E1_28J9E
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	166	1.000	Inparanoid score	I4157
OMA	1	1.010	-	-		QHG47953
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004644
OrthoInspector	1	1.000	-	-		otm26484
orthoMCL	1	0.900	-	-		OOG6_108352
Panther	1	1.100	-	-	LDO	PTHR12433
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4646
SonicParanoid	1	1.000	-	-		X6592
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.880