DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MED25 and Med25

DIOPT Version :9

Sequence 1:	NP_650854.1	Gene:	MED25 / 42385	FlyBaseID:	FBgn0038760	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	XP_006229069.3	Gene:	Med25 / 292889	RGDID:	1305137	Length:	863	Species:	Rattus norvegicus

Alignment Length:	884	Identity:	247/884 - (27%)
Similarity:	353/884 - (39%)	Gaps:	246/884 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LADVVFVIEGSAINGAYINELKTNYILPTLEHFTTGSIDEREYLIAERFATLYGIVVYRTAANLL 72
            :|||||||||:|..|.|...|:.:|:||.:|:|..|...|.:: ..:...|.|.:||:.|.....
  Rat    76 VADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDF-GGDYGGTQYSLVVFNTVDCAP 139

  Fly    73 EPVCSTYGPFLQPQKVMETIERLPLVGGGMESCAHMAEGFAAAHGCFDDISERRQLLDQTSVQRH 137
            |.....:.|.....:.:..::.:..:|||.|||:.:|||.:.|...|||..:.|:.:.||  .|.
  Rat   140 ESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQT--HRV 202

  Fly   138 CILICNSPPYQMPTTESWKYPGKSCEQLAALFNERKINLSIIAPRKMPVLFKLFMKA------DG 196
            |:||||||||.:|..||..|.|.:.|.|.....||.|:.||::|||:|.|..||.||      :.
  Rat   203 CLLICNSPPYLLPAVESTTYSGCTTESLVQKIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEP 267

  Fly   197 DQPITSKNYAKNIRHLVLLKGYSL-------------KERA---PSPNSMAAQMAAPNAAQATVQ 245
            .||  ..:.:::.||:||::|..|             |:..   |:|.|.|...|||......|.
  Rat   268 LQP--PADVSQDPRHMVLVRGLVLPVGGSSAPGPLQPKQAVPLPPAPTSAATLSAAPQQTLPPVP 330

  Fly   246 QQQQQQQNQAGQQQQGQGMPMDTTPAQQQQQQQQQQQQQQQQG-NPQQQVMNMNTMQQQQPGPNP 309
            .|.|              :|.:.:.||...|...:..:.|:.| .|  :...:|.:||...|..|
  Rat   331 PQYQ--------------VPGNLSAAQVAAQNAVEAAKNQKAGLGP--RFSPINPLQQAASGVGP 379

  Fly   310 PAGLLNPQQQQQLLQQQQQNQFVSNQMQNQNFQQNVGPGQNRWMYPNQPGQARPPFMQGAGNVGG 374
            |                              |.|...|.    :.|..||..:||
  Rat   380 P------------------------------FSQAPAPP----LAPGPPGAPKPP---------- 400

  Fly   375 VGQGGGMQQNPNS--ALISRINAPPPNQTVTSLQQQQQQQAQQQQQQQQQAQQQQQQRMQMLSQQ 437
                      |.|  :|:|.: ||.|.
  Rat   401 ----------PASQPSLVSTV-APGPG-------------------------------------- 416

  Fly   438 QMLNHQQLQQQQQLAQQQQQQQQGQQQQQVNPNAGNNMMPASNAGNMSNPQQQQQQVGQQSNPQQ 502
                         ||...|......|...|.|            |.:|.|           :|.|
  Rat   417 -------------LAAPAQPGAPSMQAGTVTP------------GGVSGP-----------SPAQ 445

  Fly   503 QGNPQQQQQGNSQQEQASLREKIWTGVLEWSEKPK----SDQQKIPHTLQCTVCTNIKDGEPEIK 563
            .|.|     ....|:..|.:...|:|||||.||||    ....|:..:|.|.|..|  .|| .:|
  Rat   446 LGGP-----ALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVN--HGE-NLK 502

  Fly   564 AENWPPKLLMQLMPKHLVGNIGGQFLKDSKMVVFRPTPG--EALDSLAKMMTSGYAGCVHFSSIP 626
            .|.||.||:|||:|:.|:..:|..| ::|:||.|..|..  |:|..|.::|.:|:||||||   |
  Rat   503 TEQWPQKLIMQLIPQQLLTTLGPLF-RNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHF---P 563

  Fly   627 NSPACDLKVLILLYTPDRNAFLGFIPNNQAMFVERLRKVIQQKQHGNMQQQQQQQQ--------- 682
            ::..|:::||:|||:..:..|:|.||.:|:.||..:|:||  ..|..:|||:.:||
  Rat   564 HTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVI--TNHKQVQQQKLEQQRGMGAQQAP 626

  Fly   683 -----MMQQQGKSPMELQQQQQQQQQQQ---QMQQDNSQQQHYNQFQLNMQMGGGGPGGGPGPGP 739
                 :::.|.:.|..|.|.:..|.|.|   .......|.|.....|.......|.||..|||.|
  Rat   627 PGLGPILEDQARPPQNLLQLRAPQPQPQGAVGASAATGQPQPQGTTQAPTGAPQGPPGAAPGPPP 691

  Fly   740 GGMPMQQNQMQMNMMQQQRMPLGVGVGVGVGPGGVPNPNLQQQLQQVAPNVAAMQQQQAQQQQQR 804
            .| |:.:.|                     .||.  ||.|:..|...||....:...||....
  Rat   692 SG-PILRPQ---------------------NPGA--NPQLRSLLLNPAPPQTGVPPPQASLHH-- 730

  Fly   805 MVRPMMSNNNPGLRQLL-QHQTTPGNQFRPQMGGQNPNQ 842
             ::|      ||...|| .||:....|..||:....|.|
  Rat   731 -LQP------PGAPALLPPHQSLGQPQLGPQLLHPPPTQ 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED25	NP_650854.1	Med25_VWA	4..218	CDD:288159	80/215 (37%)
MED25	NP_650854.1	Med25	524..671	CDD:288130	63/152 (41%)
Med25	XP_006229069.3	Med25_VWA	73..287	CDD:402725	80/215 (37%)
		Med25_SD1	289..445	CDD:402701	50/300 (17%)
		Med25	462..607	CDD:402699	63/153 (41%)
		PAT1	<648..>779	CDD:401645	38/148 (26%)
		Med25_NR-box	719..>775	CDD:402709	14/53 (26%)
		zf-C2H2_12	790..848	CDD:408440
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336634
Domainoid	1	1.000	135	1.000	Domainoid score	I4847
eggNOG	1	0.900	-	-		E1_28J9E
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	147	1.000	Inparanoid score	I4317
OMA	1	1.010	-	-		QHG47953
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004644
OrthoInspector	1	1.000	-	-		mtm9099
orthoMCL	1	0.900	-	-		OOG6_108352
Panther	1	1.100	-	-	LDO	PTHR12433
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6592
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.850