Protein Alignment CG31213 and Abca2

DIOPT Version :9

• Sequence 1: NP_001262752.1
• Gene: CG31213 / 42382
• FlyBaseID: FBgn0051213
• Length: 1809
• Species: Drosophila melanogaster
• Sequence 2: XP_006233707.2
• Gene: Abca2 / 79248
• RGDID: 620238
• Length: 2435
• Species: Rattus norvegicus
• Alignment Length: 2115
• Identity: 486/2115 - (22%)
• Similarity: 847/2115 - (40%)
• Gaps: 514/2115 - (24%)

  Fly     4 NLT-YCQKYRLLLWKDIKLQLTNWVEL----------------------VMIIFLSALMPI---- 41
            |:| |.|     :|.:|..::.:::|.                      .|.:.|..|.|.
  Rat   485 NVTHYAQ-----VWLNISAEIRSFLEQGRLQQHLHWLQQYVADLRLHPEAMNLSLDELPPALRLD 544

  Fly    42 FFSI--GTKVAKSIFPPDIEMEKSPGPKSVNTSLFVDLY--FTPNNGILEQLITQL--ANISEFK 100
            :||:  ||.:.:.:   |.....:.|.....:.:.||::  |.....|:...:.|.  .|::.|.
  Rat   545 YFSLPNGTALLQQL---DTIDNAACGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFA 606

  Fly   101 SVEVFDTNSELYLQLMINRNAIGIAFPSEWYDIK---SCPEVLNLTIFMPLSIKRKDFK------ 156
            || :|.|..:            |...|...|.|:   |..|..|       .|:|..::
  Rat   607 SV-IFQTRKD------------GSLPPHVHYKIRQNSSFTEKTN-------EIRRAYWRPGPNTG 651

  Fly   157 ---YFESGFLLLQERISKIFIFFKN--AGNGKI-PRVLMNHFPYPSYVPNHYAESAKAMTYMTLI 215
               ||..||:.:|:.|.:..|   |  .|:..: |...:..||||.|..:         .::.:|
  Rat   652 GRFYFLYGFVWIQDMIERAII---NTFVGHDVVEPGNYVQMFPYPCYTRD---------DFLFVI 704

  Fly   216 SFFLP-CITIA---------KYVVAEKERHQKAVLTAMGFSNSIHWLAWYTKSMLLLLLCLLIMI 270
            ...:| |:.|:         :::|||||...|.|:..||.:|::||:||:....:.|.:.:..:.
  Rat   705 EHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALT 769

  Fly   271 SIFSIGLIYEFSSLVCLMTIFLVYIHSLVLFAFFISSFFSRSLSAVVATILMYFSTALPFL---- 331
            :|...|.:...|.::.:.....||..:.::|.|.:|..:|::..|.....::||.:.:|::
  Rat   770 AILKYGQVLMHSHVLIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAI 834

  Fly   332 --------IVGAENSSVAAQTAASIGLNSALFYILDSVAVMEMQSVGAQWYTIDNTASSG--YKL 386
                    |...|....:..:..:.||.|..|      |:.|:..||.||:|...:...|  :.|
  Rat   835 REEVAHDKITAFEKCIASLMSTTAFGLGSKYF------ALYEVAGVGIQWHTFSQSPVEGDDFNL 893

  Fly   387 SIVGYMLIMISI-----SWIELLICLYIEAVRTGEFEVPQPWSYPFQRRYWCPLRYGSSVFHQGA 446
            .:...||::.::     :|       |||||..|.:.:|:||.:|.|:.||    .||
  Rat   894 LLAVTMLMVDTVVYGVLTW-------YIEAVHPGMYGLPRPWYFPLQKSYW----LGS------- 940

  Fly   447 LLPLAGKNS--EGNLPAAH-----------------------------PTRQPIIYLDDRTQENF 480
                 |:..  |.:.|.||                             ||..|::...|:..:.:
  Rat   941 -----GRTETWEWSWPWAHAPRLSVMEEDQACAMESRHFEETRGMEEEPTHLPLVVCVDKLTKVY 1000

  Fly   481 QRVNISKKIGIEVRSLSKTFGFRNVVKDLFFNVYENEITALVGHKGSGKTTIIMMLCGILQPTTG 545
            :.   .||:.:...||               |:|||::.:.:||.|:||||.:.:|.|:..||:|
  Rat  1001 KN---DKKLALNKLSL---------------NLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSG 1047

  Fly   546 TVLINGYDIVTEAKVAKSSLGICPQHSVIFKGMSARDHIYFFSRVKGYNKTEAMMESNIYISKLG 610
            :..|.|:||.||....:.:||:||||:|:|..::..:|::|:||:|...:.|...|.:..|..|.
  Rat  1048 SATIYGHDIRTEMDEIRKNLGMCPQHNVLFDQLTVEEHLWFYSRLKSMAQEEIRKEMDKMIEDLE 1112

  Fly   611 LVDSQKWDAMRLSPGNQRRLSLACALCAGSKVILCDEPSSGLDPIGRHELMRFLQKEKHGRTILM 675
            |.:.:......||.|.:|:||:|.|...||:.|:.|||::|:||..|..:...:.|.|.|||||:
  Rat  1113 LSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILL 1177

  Fly   676 TTQQLEEGEILADRIAIMNDGQILCYGTLGYLKQLPFTSYTLSCQMAP----------------- 723
            :|..::|.::|.|||||::.|::.|.|:..:||......|.|:....|
  Rat  1178 STHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGAYGDGYRLTLVKRPAEPGTSQEPGMASSPSG 1242

  Fly   724 -----NSKADNLTDLVRLYMTTTTSPVFHGVDVSYKLPRSQIDR--FPEFFQQLEENKKSLNVVS 781
                 |.....::..:|.::.::........::||.||...:.:  |...|||||.:..:|::.|
  Rat  1243 RPQLSNCSEMQVSQFIRKHVASSLLVSDTSTELSYILPSEAVKKGAFERLFQQLEHSLDALHLSS 1307

  Fly   782 FGVSDSTLDGIYL-------SLDYGQGS-SRLRGGADPGVNDKVEFGVQTDKAIRTKDRANN--S 836
            ||:.|:||:.::|       ||:..:.. ...|..|.||.........|.....|..:.|.:  |
  Rat  1308 FGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDALPGAEGLTAVESQAGNLARCSELAQSQAS 1372

  Fly   837 LVR-------------------------YQHQVDPPN--------ETILNTKTPINPIEIWRPID 868
            |..                         :.:..||.:        |.:.........:|.|
  Rat  1373 LQSASSVGSARGDEGAGYTDGYGDYRPLFDNLQDPDSVSLQEAEMEALARVGQGSRKLEGW---- 1433

  Fly   869 REKGSCMAQWQAMFIKKKNYTASRALIFILILIIPLFYYIIVLGTAASEKCAHRTDKQPVLPLSL 933
               ...|.|:..:.:|:.:.....:......:::|.|:..:.:..|.|  .....|..|::....
  Rat  1434 ---WLKMRQFHGLLVKRFHCARRNSKALCSQILLPAFFVCVAMTVALS--VPEIGDLPPLVLSPS 1493

  Fly   934 DYYSY----DDMIILLEVDKQLYK------SEGEAYVQLVKEPATVESVDSIFSHLLKAP----- 983
            .|::|    .:.|.....:::.|:      :..:..|...:.|:.|.:     :.:||:|
  Rat  1494 QYHNYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGA-----TCVLKSPANGSL 1553

  Fly   984 -PIIRRDIKRKYVCGASFNNASTITAWFNSDAFEHSAPIALNLVYNALGKA-----VFEDQDFSI 1042
             |::........:..|.|.::..:      ::|....|:: |.|......|     :..|:| |:
  Rat  1554 GPMLNLSSGESRLLAARFFDSMCL------ESFTQGLPLS-NFVPPPPSPAPSDSPLSPDED-SL 1610

  Fly  1043 LVNRGDL------HDFIWLNNASSMRRRYKRQ--------------------NDPD--------Y 1073
            |.....|      ..:.|   |.|:.|.....                    :.|.        .
  Rat  1611 LAWNTSLPPTAGPETWTW---APSLPRLVHEPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDIL 1672

  Fly  1074 TDYSDYEIQEYDVVVKPN------SSSTSGQHNKSNPGD----DNIITVQMSIIEAASTLYNEKG 1128
            ||.:.:.:.||.:.....      .:.|.|...||.|..    ..::..::::...|..|||.||
  Rat  1673 TDITGHNVSEYLLFTSDRFRLHRYGAITFGNIQKSIPAPIGTRTPLMVRKIAVRRVAQVLYNNKG 1737

  Fly  1129 KRKQ-----------------------------------------------LFGTLIIITAYIAL 1146
            ....                                               |.||.::|..:|.:
  Rat  1738 YHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGTDVVIAIFIIV 1802

  Fly  1147 CLSI----FSIFVTKERVEHFKMQQEIYGVTLFYFWSTHFVGDFLIYAIYMGALTIAIYHF---- 1203
            .:|.    |.:|:..|:....|..|.:.|.....:|..::|.|.|.|.:......|.::.|
  Rat  1803 AMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPVIYWLANYVWDMLNYLVPATCCIIILFVFDLPA 1867

  Fly  1204 ----TIWYQVVVMLLLIGFACLPFVYLCSLLFSLPNIAFAGIFAILVMTGGMLFSFMYMLTL--- 1261
                |.:..|:.:.||.|::..|.:|..|..|.:|:.|:..:..|.:..|.......::|.|
  Rat  1868 YTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEH 1932

  Fly  1262 -----ITDVNFTTVFAILPMYVGTFGLFKCLAWREYCNREVLPPIEELDCKFGNCNVFCACKPER 1321
                 :.:....:.|.|.|.|....||.: :|:.||.|        |...|.|.   |...|...
  Rat  1933 DKDLKVVNSYLKSCFLIFPNYNLGHGLME-MAYNEYIN--------EYYAKIGQ---FDKMKSPF 1985

  Fly  1322 TWMEVW----LLMVHCLVWFIFLWFSNFGY-----EIGYRFKPKLSNRIWHNNEKHIRVLDEERR 1377
            .|..|.    .:.|...|.|.......:.:     .:....||.         |..:.|..|.:|
  Rat  1986 EWDIVTRGLVAMTVEGFVGFFLTIMCQYNFLRQPQRLPVSTKPV---------EDDVDVASERQR 2041

  Fly  1378 VGLIPKYEHEDYPIIVDQVTKNYCRAK----NAVQLVSFAIRPGDTFGLLGAQGAGKTSIFQMIA 1438
            |   .:.:.::..:.::.:||.|...|    .||..:...:|||:.|||||..||||||.|:|:.
  Rat  2042 V---LRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLT 2103

  Fly  1439 GETSMSHGNIYVRGHSLREHRNAAKMEVGFCPQGDNAPKYLTGRQLLRIHCLLHGVP-KDHIKAV 1502
            |:.|.:.|..:|.|||:.:.....:..:|:|||.|.....||.|:.|:::..|.|:| ||..:.|
  Rat  2104 GDESTTGGEAFVNGHSVLKDLLQVQQSLGYCPQFDALFDELTAREHLQLYTRLRGIPWKDEAQVV 2168

  Fly  1503 SEQMAIEFNFKDQL----DRPIHTYSGGKKRKLNIALA-IDSGSVLCLDDTNGSVDHATQRFIWR 1562
              :.|:|   |.:|    |:|..:||||.||||:.|:| |...:.:.||:....:|...:||:|.
  Rat  2169 --RWALE---KLELTKCADKPAGSYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWN 2228

  Fly  1563 KLEAVKRSGRPVLLTTQSMEEANAVCSRVAFLVAGEMMFIGSLQQVRSEVSNTIVIRLRVNPSDG 1627
            .:..:.::||.|:||:.||||..|||:|:|.:|.|.:..:||:|.:::...:..:|.:|...|
  Rat  2229 LILDLIKTGRSVVLTSHSMEECEAVCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSS-- 2291

  Fly  1628 KLKRRFQQLIADMAEL----FPLATLHEALETCLIYHININVTTLANLFYQMEKIRNEGLLEDYS 1688
                   |.:.|:...    ||.|.|.|...|.:.|.:.....:||.:|.:||.:.....:||||
  Rat  2292 -------QNVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEHVVGVLGIEDYS 2349

  Fly  1689 ITQVSLDEIY---------RILNDEEDPN-------LVDL--DSTHNSEVLEDIRDTTRDTTRGT 1735
            ::|.:||.::         .:...|.:|:       |:.|  .....:|:...:.|...|.   .
  Rat  2350 VSQTTLDNVFVNFAKKQSDNVEQQEAEPSTLPSPLGLLSLLRPRPAPTELRALVADEPEDL---D 2411

  Fly  1736 TRDTNLVSDEGIQKEKVKRKKVEEEDRDRQESTET 1770
            |.|..|:|             .|||......:|:|
  Rat  2412 TEDEGLIS-------------FEEERAQLSFNTDT 2433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31213	NP_001262752.1	ABC2_membrane_3	32..>295	CDD:289468	67/297 (23%)
		ABC_subfamily_A	491..708	CDD:213230	78/216 (36%)
		drrA	498..796	CDD:130256	101/328 (31%)
		ABC2_membrane_3	<1132..1285	CDD:289468	40/219 (18%)
		CcmA	1391..1672	CDD:224054	100/294 (34%)
		ABC_subfamily_A	1391..1609	CDD:213230	86/227 (38%)
Abca2	XP_006233707.2	rim_protein	1..2369	CDD:130324	470/2033 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342254
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860