DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31213 and abca7

DIOPT Version :9

Sequence 1:	NP_001262752.1	Gene:	CG31213 / 42382	FlyBaseID:	FBgn0051213	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	XP_009304071.2	Gene:	abca7 / 561460	ZFINID:	ZDB-GENE-050517-6	Length:	2328	Species:	Danio rerio

Alignment Length:	2040	Identity:	478/2040 - (23%)
Similarity:	839/2040 - (41%)	Gaps:	433/2040 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DIKLQLTNWVELVMIIFLSALMPIFFSIGTKVAKSIFPPDIEMEKSPGPKSVNTSLFVDLYFTPN 82
            :::|:.|:|.                  .:::|:.:...|.:..:..|.:..    :.|||...|
Zfish   458 NMRLENTSWT------------------ASRIARFLSTQDPDTPRKDGAQLT----WFDLYQDLN 500

  Fly    83 NGILEQLITQLANISEFKSVEVFDTNSELY---LQLMINRNA-IGIAF--PSEWYDIKSCPEVLN 141
            |..  ..:::|........:|...|..|:.   |:|:.:|.. .||.|  |:....:  .|..:.
Zfish   501 NTF--TTLSELTKCFSLNKLEGLTTEGEMVERALELLEDRQFWAGIVFLLPNSSSSV--LPPHVK 561

  Fly   142 LTIFMPL-------SIKRK------------DFKYFESGFLLLQERISKI---FIFFKNAGNGKI 184
            ..|.|.:       .||.|            |.:|...||:.:|:.:.:.   .:..|.|..|
Zfish   562 YKIRMDIDDVTRTNKIKDKFWDPGPAAEPFSDMRYVWGGFVYVQDLVERAVTRLLTGKEAKTG-- 624

  Fly   185 PRVLMNHFPYPSYVPNHYAE--SAKAMTYMTLISFFLPCITIAKYVVAEKERHQKAVLTAMGFSN 247
              :.:...|||.:|.:.:..  :.....:||| ::......|.|.||.|||...|..:..||..:
Zfish   625 --IYVQQMPYPCFVDDVFIRVLNRSLPLFMTL-AWIYSVAMIIKGVVYEKEARLKETMRIMGLGS 686

  Fly   248 SIHWLAWYTKSMLLLLLCLLIMISIFSIGLIYEFSSLVCLMTIFLVYIHSLVLFAFFISSFFSRS 312
            .:.|.:|:..|.|..|....::|:....|.|..:|....:......:..:.::..|.||:||||:
Zfish   687 GMLWFSWFISSYLPFLFSAALLIAALKWGDILPYSDPAVVFFFLAAFATATIMLCFLISTFFSRA 751

  Fly   313 LSAVVATILMYFSTALPFLIVGA--ENSSVAAQTAASIGLNSALFYILDSVAVMEMQSVGAQWYT 375
            ..|.....|:||:..||:::..|  |..:...:..||.....|..:..:..:..|.|.||.||:.
Zfish   752 NLAAACGGLIYFTLYLPYVLCVAWREYLTSTHRILASFLSPVAFGFGCEYFSQYEEQGVGIQWFN 816

  Fly   376 IDNTASSGYKLSIVGYMLIMISISWIELLICLYIEAVRTGEFEVPQPWSYPFQRRYWCPLRYGSS 440
            :.::...|...|....::::.:.:.|..|...|||||..|::.:|:||.:.||..||     |..
Zfish   817 LKSSPMEGDTYSFNTSIMMLYADALIYALATWYIEAVFPGQYGIPRPWYFIFQLNYW-----GGV 876

  Fly   441 VFHQGALLPLAGKNSEGNLPAAHPTRQPIIYLDDRTQENFQRVNISKKIGIEVRSLSKTF--GFR 503
            ....|..:|.|.:..:.....|.||                  |:.  :|:.:|:|.|.:  |.:
Zfish   877 PLELGLPIPPAPREEQDARIEAEPT------------------NLI--LGVSIRNLVKIYKKGAK 921

  Fly   504 NVVKDLFFNVYENEITALVGHKGSGKTTIIMMLCGILQPTTGTVLINGYDIVTEAKVAKSSLGIC 568
            ..|..|....||.:||:.:||.|:||||.:.:|.|:..||.||:.:.|.||.::..:.:.:||:|
Zfish   922 LAVNHLNIKFYEGQITSFLGHNGAGKTTTMSILTGLFPPTAGTIYVKGMDIRSDMDIIRRTLGVC 986

  Fly   569 PQHSVIFKGMSARDHIYFFSRVKGYNKTEAMMESNIYISKLGLVDSQKWDAMRLSPGNQRRLSLA 633
            |||:|:|..::..:|::|:.|:||.:..|...|.|..:..:||...:......||.|.||:||:|
Zfish   987 PQHNVLFDILTVEEHVWFYGRMKGMSLEEVNKEMNSLLEDVGLQHKRFEQTKNLSGGMQRKLSVA 1051

  Fly   634 CALCAGSKVILCDEPSSGLDPIGRHELMRFLQKEKHGRTILMTTQQLEEGEILADRIAIMNDGQI 698
            .|...||||::.|||::|:||..|..:...|.|.:.||||:::|..::|.::|.|||||::.|::
Zfish  1052 IAFIGGSKVVVLDEPTAGVDPYSRRGIWDLLLKYREGRTIILSTHYMDEADLLGDRIAIISQGKL 1116

  Fly   699 LCYGTLGYLKQLPFTSYTLS-------------------CQMAPNSKADNLTD------------ 732
            .|.||..:||....|.|.|:                   ...:|.....:::|
Zfish  1117 CCCGTPLFLKARLGTGYYLTLVKREMHRTPSNTSSGKIPSAASPKDSDSSVSDDTGLGSEENGFD 1181

  Fly   733 ------LVRLYMTTTTSPVFHGVDVSYKLPR--SQIDRFPEFFQQLEENKKSLNVVSFGVSDSTL 789
                  |.:.|:.........|.:....||.  |:......|..:|::.:....|||:|:||:||
Zfish  1182 VAALMALAQQYVPDAQLVEDIGREAVINLPNAASEDGTLALFLNELDKRQGEFGVVSYGLSDTTL 1246

  Fly   790 DGIYLSLDYGQGSSRLRGGADPGVNDKVEFGVQTDKAIRTKDRANNSLVRYQHQ-VDPPNETILN 853
            :.|:|.:....|..  ....||.|:.:.:.....|     :|.|....:|.:.| .||.:....:
Zfish  1247 EEIFLRVAEETGVD--ADPEDPPVSQEPQGAPSED-----RDAARKRSIRKEAQETDPLSGDGQS 1304

  Fly   854 TKTPINPIEIWRPIDREKGSCM---AQWQAMFIKKKNYT-ASRALIFILILIIPLFYYIIVL--- 911
            ...|:.             .|.   .|.:|:|.|:..|. .||..||..|::..:|..|.:|
Zfish  1305 DSAPLT-------------GCFHTCQQLRALFTKRLKYAFRSRRGIFAQIVLPAVFVLIALLFSL 1356

  Fly   912 ------------------------------------------------GTAASE-----KCAHRT 923
                                                            ||...:     :|..:.
Zfish  1357 IVPPFGKYPSLELQPWMYGEQFTFFSNDAPQDPAMQNLLKALLDPPGFGTKCMQPNGDTECLAKA 1421

  Fly   924 DK---QPVLPLSLDYYSYDDMIILLEVDKQLYKSEGEAYVQLVKE---------PATVESVD--- 973
            :.   :|.:|.|: :..:.:....:|......:...|...:::.|         |..::.:.
Zfish  1422 ETKFVRPQIPYSM-WQLFHNGNFSIEKPSPECECSTEKIRRMLPECPEGAGGVPPPQMQQITGDI 1485

  Fly   974 -------SIFSHLLKA-PPIIRRDIK-RKYV-----CGASFNNASTITAWFNSDAFEHSAPIALN 1024
                   :|..:|:|. |.|:::.:| :|:|     .|.|....|::|  .:.......:.:|:.
Zfish  1486 LQNLTGRNISDYLIKTYPQILKKSLKTKKWVNEFRYGGFSLGAKSSLT--MSEPHHLEESVLAIR 1548

  Fly  1025 LVYNALGKAVFEDQDFSILVNRGDLHDF-----------IWLNN---------ASSMRRRYKRQN 1069
            ..||     :.|:.....|:.|  |.|.           :|.||         .:.|.....|.|
Zfish  1549 RRYN-----IAENGSLDQLLQR--LPDVLSGLTSQNNVKVWFNNKGWHAMASFVNIMNNGLLRAN 1606

  Fly  1070 DPDYTDYSDYEIQEYDVVVKPNSSSTSGQHNKSNPGDDNIITVQMSIIEAASTLYNEKGKRKQLF 1134
            .|..|:...|.|..|:..:                   |:...|::.:...:|..:
Zfish  1607 LPPKTERRKYGITAYNHPL-------------------NLTKEQLTEMALMTTSVD--------- 1643

  Fly  1135 GTLIIITAYIALCLSI----FSIFVTKERVEHFKMQQEIYGVTLFYFWSTHFVGDFLIYAIYMGA 1195
               ::::..:...:|.    |.:|:.:|||...|..|.:.||....:|:|::|.|.:.|.:   .
Zfish  1644 ---VLVSICVIFAMSFVPASFVLFLIEERVSKSKHLQFVSGVKPILYWTTNYVWDMVNYTV---P 1702

  Fly  1196 LTIAIYHFTIWYQ-----------VVVMLLLIGFACLPFVYLCSLLFSLPNIAFAGIFAILVMTG 1249
            .|:.::.|..:.|           :|::|||.|::..|.:|..|.:||:|:.|:..:.:|.:..|
Zfish  1703 ATMVVFIFISFQQESYVSEKNLPALVLLLLLYGWSITPLMYPASFIFSVPSTAYVVLTSINLFIG 1767

  Fly  1250 --GMLFSFMYMLTL---ITDVN--FTTVFAILPMYVGTFGLFKCL-------AWREYCNREVLPP 1300
              |.:.:|:..|.:   :.:||  ...||.|.|.:....||....       |::....::.|.|
Zfish  1768 INGSVATFVLELFVDEHLNEVNRILKKVFLIFPHFCLGRGLIDMAKNQAMADAFQRLGTKQNLDP 1832

  Fly  1301 IEELDCKFGNCNVFCACKPERTWMEVWLLMVHCLVWFIFL------WFSNFGYEIGYRFKPKLSN 1359
               |...|...|:|.             :.:..:|:|:|.      :|.||....|:...|
Zfish  1833 ---LSWDFVGKNLFA-------------MAMEGIVFFLFTVLLQYKFFVNFSRWSGFVLPP---- 1877

  Fly  1360 RIWHNNEKHIRVLDEE-----------RRVGLIPKYEHEDYPIIVDQVTKNY-CRAKNAVQLVSF 1412
                     :.:.||:           |.:|.|         :|:..::|.| ...|.||..:..
Zfish  1878 ---------LGMEDEDVARERERVKNGRALGDI---------LILSDLSKVYKAGRKPAVNRLCL 1924

  Fly  1413 AIRPGDTFGLLGAQGAGKTSIFQMIAGETSMSHGNIYVRGHSLREHRNAAKMEVGFCPQGDNAPK 1477
            .|..|:.|||||..||||||.|:|:.|:|.:::|..::...|:..........:|:|||.|....
Zfish  1925 GIPRGECFGLLGVNGAGKTSTFRMLTGDTRITYGEAFLSNQSVLTEMEKVHQLMGYCPQFDAIID 1989

  Fly  1478 YLTGRQLLRIHCLLHGVPKDHIKAVSEQMAIEFNFKDQLDRPIHTYSGGKKRKLNIALA-IDSGS 1541
            .||||:.|..:..|.|||:.:::.|::....:.......||....||||.||||:.|:| |.:..
Zfish  1990 LLTGREHLEFYARLRGVPESYVEKVAQWGVQKLGLSQYADREAGGYSGGNKRKLSTAIALIGAAP 2054

  Fly  1542 VLCLDDTNGSVDHATQRFIWRKLEAVKRSGRPVLLTTQSMEEANAVCSRVAFLVAGEMMFIGSLQ 1606
            |:.||:....:|...:||:|..:.:|.:.||.|:||:.||||..|:|:|:|.:|.|....:||:|
Zfish  2055 VIFLDEPTTGMDPKAKRFLWNCILSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFQCLGSVQ 2119

  Fly  1607 QVRSEVSN--TIVIRLRVN-----PSDGKLKRRFQQLIADMAELFPLATLHEALETCLIYHININ 1664
            .:::...:  ||::||...     |.|           |.:...||...|.|..:..|.|.:...
Zfish  2120 HLKNRFGDGYTIILRLSTPSAEPCPVD-----------AYIQNAFPGIQLKERHQNVLQYQLPSQ 2173

  Fly  1665 VTTLANLFYQMEKIRNEGLLEDYSITQVSLDEIY-RILNDE-EDPNLVDLDSTHNSEVLEDIR-- 1725
            ..:||.:|..:.....|..:.|||::|.:||::: ....|: :|..|.::.....|..|:..|
Zfish  2174 TCSLARVFEVLSNNYEELGIADYSVSQTTLDQVFVNFAKDQTDDDQLREITINGGSVALQPNRPQ 2238

  Fly  1726 -----DTTRDTTRGTTRDTNLVSDE----GIQKEKVKRKKVEEEDRDRQ-------ESTETSKPK 1774
                 ..::.:...|.|..:..|.|    |.:.:|.|.|......:.:|       |:...|.|.
Zfish  2239 RPTDLQLSKTSRSSTPRSPSTTSTEPQSTGSKTKKSKSKSPSVSKQQQQMRMEPVGEAANGSNPT 2303

  Fly  1775 VKRSPATQSD------STDTDEMEV 1793
            ..:||..:..      |..|.|.:|
Zfish  2304 EDQSPGRKDPSVLFIVSNKTQESKV 2328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31213	NP_001262752.1	ABC2_membrane_3	32..>295	CDD:289468	59/292 (20%)
		ABC_subfamily_A	491..708	CDD:213230	82/218 (38%)
		drrA	498..796	CDD:130256	105/338 (31%)
		ABC2_membrane_3	<1132..1285	CDD:289468	43/174 (25%)
		CcmA	1391..1672	CDD:224054	94/289 (33%)
		ABC_subfamily_A	1391..1609	CDD:213230	79/219 (36%)
abca7	XP_009304071.2	AAA	1..2220	CDD:333001	456/1930 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920