DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31213 and Abca17

DIOPT Version :9

Sequence 1:	NP_001262752.1	Gene:	CG31213 / 42382	FlyBaseID:	FBgn0051213	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	NP_001026792.2	Gene:	Abca17 / 381072	MGIID:	3625331	Length:	1733	Species:	Mus musculus

Alignment Length:	1906	Identity:	472/1906 - (24%)
Similarity:	825/1906 - (43%)	Gaps:	452/1906 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QKYRLLLWKDIKLQLTNWVELVMIIFLSALMPIFF----------SIGTKVAKSIFPPDIEMEKS 63
            :|.:|||||:..|:...    .:|..|..|||:.|          |:..|.:.:.:|
Mouse     5 KKLKLLLWKNFILKRRK----TLITLLEMLMPLLFCAIVLYLRLNSMPRKKSSTNYP-------- 57

  Fly    64 PGPKSVNTSLF------------VDLYFTPNNG--------ILEQLITQLANISEFKSVEVFD-- 106
                :|:.||.            ..|.:.|:..        ::||.......:..|.||.:|:
Mouse    58 ----AVDVSLLPVYFYNYPLKSKFQLAYIPSKSETLKAVTEVVEQTFAVDFEVLGFPSVPLFEDY 118

  Fly   107 ---TNSELYLQLMINRNAIGIAFPSEWYDIKSCPEVLNLTI------------------------ 144
               .....|:       .:||.|   .:|..|..|.|.|.:
Mouse   119 IIKDPKSFYI-------LVGIIF---HHDFNSSNEPLPLVVKYDLRFSYVQRNFVSPPRHLFFQE 173

  Fly   145 ----------FMP-LSIKRKDFKYFE--------SGFLLLQERISKIFI----------FFKNAG 180
                      :.| ||...::|.|.:        .|||.:|..:.|..:          .||:.
Mouse   174 EIEGWCTAFLYPPNLSQAPREFSYADGGNPGYNKEGFLAIQHAVDKAIMRHHAPKAALNMFKDL- 237

  Fly   181 NGKIPRVLMNHFPYPSYVPNHYAESAK-AMTYMTLISFFLPCITIAKYVVAEKERHQKAVLTAMG 244
                 .||:..||:..::.:.:....: ....:.::||....:.|...|::||||.||..::.||
Mouse   238 -----HVLVQRFPFGPHIQDPFLVILQNEFPLLLMLSFICVELIITNSVLSEKERKQKEYMSMMG 297

  Fly   245 FSNSIHWLAWY---------TKSMLLLLLCLLI-MISIF---SIGLIYEFSSLVCLMTIFLVYIH 296
            ..:.:||:||:         |.|::.:|.|..| .:::|   :..||:.|.....:.|||
Mouse   298 VESWLHWVAWFITFFISVSITVSVMTVLFCTKINRVAVFRNSNPTLIFIFLMCFAIATIF----- 357

  Fly   297 SLVLFAFFISSFFSRSLSAVVATIL---MYFSTALPFLIV--GAENSSVAAQTAASIGLNSALFY 356
                |||.:|:||.|   |.|.|::   ::|.|.||::.:  .....:...:..:.:..|.|:..
Mouse   358 ----FAFMMSTFFQR---AHVGTVIGGTVFFFTYLPYMYITFSYHQRTYTQKILSCLFSNVAMAT 415

  Fly   357 ILDSVAVMEMQSVGAQWYTIDNTASSGYKLSIVGYMLIMISISWIELLICLYIEAVRTGEFEVPQ 421
            .:..:::.|.:..|.||..|.:.........::|.:|:   .|::..||...:|::...:|.:|:
Mouse   416 GVRFISLFEAEGTGIQWRNIGSVWGDFSFAQVLGMLLL---DSFLYCLIAFLVESLFPRKFGIPK 477

  Fly   422 PWSYPFQRRYWCPLRYGSSVFHQGALLPLAG-----KNSEGNLPAAHPTRQPIIYLDDRTQENFQ 481
            .| |.|.::   |:         ..:.||..     |.|:||.....||.|
Mouse   478 SW-YIFAKK---PV---------PEIPPLLNIGDPEKPSKGNFMQDEPTNQ-------------- 515

  Fly   482 RVNISKKIGIEVRSLSKTF----GFRNVVKDLFFNVYENEITALVGHKGSGKTTIIMMLCGILQP 542
             :|.     ||::.|.|.|    ..|..::||..|:|:.::|.|:||.|:||||:..:|.|::.|
Mouse   516 -MNT-----IEIQHLYKVFYSGRSKRTAIRDLSMNLYKGQVTVLLGHNGAGKTTVCSVLTGLITP 574

  Fly   543 TTGTVLINGYDIVTEAKVAKSSLGICPQHSVIFKGMSARDHIYFFSRVKGYNKTEAMMESNIYIS 607
            :.|...|:|.:|..:....:.|||.||||.::|...:..||:||:.::||.:..:...::...:.
Mouse   575 SKGHAYIHGCEISKDMVQIRKSLGWCPQHDILFDNFTVTDHLYFYGQLKGLSPQDCHEQTQEMLH 639

  Fly   608 KLGLVDSQKWDAMR--LSPGNQRRLSLACALCAGSKVILCDEPSSGLDPIGRHELMRFLQKEKHG 670
            .|||.|  ||::..  ||.|.:|:||:..||.|||||::.|||:||||...|..:...||::|..
Mouse   640 LLGLKD--KWNSRSKFLSGGMKRKLSIGIALIAGSKVLILDEPTSGLDSPSRRAIWDLLQQQKGD 702

  Fly   671 RTILMTTQQLEEGEILADRIAIMNDGQILCYGTLGYLKQLPFTSYTLSCQMAPNSKADNLTDLVR 735
            ||:|:||..::|.::|.|||||:..|::.|.|:..:|||.....|.::....|......|::::.
Mouse   703 RTVLLTTHFMDEADLLGDRIAILAKGELQCCGSPSFLKQKYGAGYYMTIIKTPLCDTSKLSEVIY 767

  Fly   736 LYMTTTTSPVFHGVDVSYKLPRSQIDRFPEFFQQLEENKKSLNVVSFGVSDSTLDGIYLSLDYGQ 800
            .::.........|.::...||:..|.||...|..||..:..|.:.:|..|.:|::.:::
Mouse   768 HHIPNAVLESNIGEEMIVTLPKKTIHRFEALFNDLELRQTELGISTFATSVTTMEEVFI------ 826

  Fly   801 GSSRLRGGADPGVNDKVEFGVQTDKAIRTKDRANNSLVRYQHQVDPPNETILNTKTPINPIEIWR 865
               |:...|||..|      |.|:|.     .:.:.|.|: |:|  |.:.|....:...|:...:
Mouse   827 ---RVCKLADPSTN------VLTEKR-----HSLHPLPRH-HRV--PVDRIKCLHSGTFPVSTEQ 874

  Fly   866 PIDREKGSCM--AQWQAMFIKKKNYTASRALIFILI-LIIPLFYYIIVLGTAASEKCAHRTDKQP 927
            |:....|.|:  .|:.||.:||..|:....::.:.: :::||  .||:|..........:.|.
Mouse   875 PMRLNTGFCLLCQQFYAMLLKKITYSRRNWMLVLSVQVLLPL--AIIMLSLTFFNFKLRKLDN-- 935

  Fly   928 VLPLSLDYYSYDDMIILL------EVDKQLYKSEGEAYVQLVKEPATVESVDSIFSHLLKAPPII 986
             :||.|...:|...|:..      .:|.||.....:..|...:.|..::.  |:...|||.....
Mouse   936 -VPLELTLQTYGQTIVPFFIAENSHLDPQLSDDFVKMLVAAGQVPLRIQG--SVEDFLLKKAKEA 997

  Fly   987 RRDIKRKYVCGASF---NNASTITAWFNSDAFEHSAPIALNLVYNALGKAVFEDQDFSILVNRGD 1048
            .....:.||..|||   ||.:|:.|.||:.|: ||..:||.||.|.|
Mouse   998 PEGFDKLYVVAASFEDVNNHTTVKALFNNQAY-HSPSLALTLVDNLL------------------ 1043

  Fly  1049 LHDFIWLNNASSMRRRYKRQNDPDYTDYSDYEIQEYDVVVKPNSSSTSGQHNKSNPGDDNIITVQ 1113
               |..|:.|                                |:|.|:..:    |.....|.|.
Mouse  1044 ---FKLLSGA--------------------------------NASITTTNY----PQPQTAIEVS 1069

  Fly  1114 MSIIEAASTLY-NEKGKR---KQLFGTLIIITAYIALCLSIFSIFVTKERVEHFKMQQEIYGVTL 1174
            .||      || ..||..   ..|||        ||...|.|||....|:....|..|.:.||:.
Mouse  1070 ESI------LYQGPKGHYLVVNFLFG--------IAFLSSSFSILTVGEKSVKSKSLQFVSGVST 1120

  Fly  1175 FYFWSTHFVGDFLIYAIYMGALTIAIYHFTIWYQ------------VVVMLLLIGFACLPFVYLC 1227
            ..||.:..:.|.:.:.:    .|:.:....:||:            ||::::|.|:|.:|.||..
Mouse  1121 AVFWLSALLWDLISFLV----PTLLLVLVFLWYKEEAFAHHESIPAVVLIMMLYGWAVIPLVYTV 1181

  Fly  1228 SLLFSLPNIAFAGIFAILVMTGGMLFSFMYMLTLIT--DVNFTT-------VFAILP---MYVGT 1280
            |..|:.|..|   ...::||...:..|.:.::|:.:  |:.:|.       :|.|||   :.:..
Mouse  1182 SFSFNTPGSA---CVKLVVMLTFLSISPVVLVTVTSEKDLGYTELSDSLDHIFLILPGHCLGMAL 1243

  Fly  1281 FGLFKCLAWREYCNREVLPPIEELDCKFGNCNVFCACKPERTWMEVWLLMVHCLVW--------- 1336
            ..|:.....:::|:.:.|   .::||              ...:|.:::..:...|
Mouse  1244 SNLYYNFELKKFCSAKNL---SDIDC--------------NDVLEGYVVQENIYAWESLGIGKYL 1291

  Fly  1337 ------------FIFLWFSNFGYEIGYRFKPKLSN---RIWHNNEKHIRVLDEERRVGLIPKYEH 1386
                        .:||..:|..|.:    |.:||.   ..|  .||...:.|       :.:.|.
Mouse  1292 TALAVLGPVYITMLFLTEANAFYVL----KSRLSGFFPSFW--KEKSGMIFD-------VAEPED 1343

  Fly  1387 EDY------------------PIIVDQVTKNYCRAKN-----AVQLVSFAIRPGDTFGLLGAQGA 1428
            ||.                  |::|.:|:|.|   |:     ||..|||.::..:.|||||..||
Mouse  1344 EDVLEEAETIKRYLETLVKKNPLVVKEVSKVY---KDKVPLLAVNKVSFVVKEEECFGLLGLNGA 1405

  Fly  1429 GKTSIFQMIAGETSMSHGNIYVRGHSLREHRNAAKMEVGFCPQGDNAPKYLTGRQLLRIHCLLHG 1493
            ||||||.|:..|..::.|:.:|:|.:::......:..:|:||:.|....::|||::|.::..:.|
Mouse  1406 GKTSIFNMLTSEQPITSGDAFVKGFNIKSDIAKVRQWIGYCPEFDALLNFMTGREMLVMYARIRG 1470

  Fly  1494 VPKDHIKAVSEQMAIEFNFKDQL-----DRPIHTYSGGKKRKLNIALA-IDSGSVLCLDDTNGSV 1552
            :|:.||||     .::...::.|     |:.:.|||||.||.|:..:| :...:|:.||:.:..:
Mouse  1471 IPECHIKA-----CVDLILENLLMCVCADKLVKTYSGGNKRMLSTGIALVGEPAVILLDEPSTGM 1530

  Fly  1553 DHATQRFIWRKLEAVKRSGRPVLLTTQSMEEANAVCSRVAFLVAGEMMFIGSLQQVRSEVSNTIV 1617
            |...:|.:|..:|.|:.||:.:::|:.||||..|:|:|:|.:|.|:...:||.|.::|:...:..
Mouse  1531 DPVARRLLWDTVERVRESGKTIVITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGISYS 1595

  Fly  1618 IRLRVNPSDGKLKRRFQQLIAD----MAEL-FPLATLHEALETCLIYHININVTTLANLFYQMEK 1677
            ::       .|::|::||.:.:    ..:| ||.:.|.:..:..|.|::.....:.|.:|..||:
Mouse  1596 LQ-------AKVRRKWQQQMLEEFKAFVDLTFPGSNLEDEHQNMLQYYLPGPNLSWAKVFSIMEQ 1653

  Fly  1678 IRNEGLLEDYSITQVSLDEIY 1698
            .:.:.:||||||:|:||::|:
Mouse  1654 AKKDYMLEDYSISQLSLEDIF 1674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31213	NP_001262752.1	ABC2_membrane_3	32..>295	CDD:289468	73/364 (20%)
		ABC_subfamily_A	491..708	CDD:213230	85/222 (38%)
		drrA	498..796	CDD:130256	101/303 (33%)
		ABC2_membrane_3	<1132..1285	CDD:289468	43/176 (24%)
		CcmA	1391..1672	CDD:224054	89/296 (30%)
		ABC_subfamily_A	1391..1609	CDD:213230	77/228 (34%)
Abca17	NP_001026792.2	rim_protein	<209..1684	CDD:130324	431/1676 (26%)
Abca17	NP_001026792.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1681..1733
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838410
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5304
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.910