Protein Alignment CG31213 and ABCA

DIOPT Version :9

• Sequence 1: NP_001262752.1
• Gene: CG31213 / 42382
• FlyBaseID: FBgn0051213
• Length: 1809
• Species: Drosophila melanogaster
• Sequence 2: NP_608445.2
• Gene: ABCA / 33103
• FlyBaseID: FBgn0031170
• Length: 1714
• Species: Drosophila melanogaster
• Alignment Length: 1874
• Identity: 520/1874 - (27%)
• Similarity: 873/1874 - (46%)
• Gaps: 358/1874 - (19%)

  Fly     5 LTYCQKYRLLLWKDIKLQLTNWVELVMIIFLSALMPIFFSIGTKVAKSIFPPDIEMEKSPGPKSV 69
            :|...|:.|||||:..||..:..::|    :..::|..||:...:.:::    ::.|:. |.:..
  Fly     4 VTNWDKFVLLLWKNWTLQWNHKWQMV----IELVLPAIFSLLLVLVRTL----VDTEQK-GVRYY 59

  Fly    70 NTSLFVD--------------------------------------LYFTPNNGILEQLITQLANI 96
            |.....|                                      |.::|.|.:|::|:.:
  Fly    60 NEQNLTDLNLLQHSLHRSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEE---- 120

  Fly    97 SEFKSV---EVFDTNSELYLQL-MINRNAI-GIAFPSEWYDIKS---CPEVLNLTIFMPLSIKRK 153
             .::|:   ::.::.:...|:| .:::||. |:.|...|.::..   .|...:..:..|..::..
  Fly   121 -AWQSLGKNKICESENATQLELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTA 184

  Fly   154 DFK--------------------------------YFESGFLLLQERISKIFIFFKNAGNGKIPR 186
            ...                                |...|||.||..:|..::..| :|...:|.
  Fly   185 TIAIANTWLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQK-SGEQDLPN 248

  Fly   187 VLMNHFPYPSYVPNHYAES-AKAMTYMTLISFFLPCITIAKYVVAEKERHQKAVLTAMGFSNSIH 250
            |:|..:|:|:|:.:...|. :..|:.:.|:||..||..|.||:.||||:..|.|:..||.||.:|
  Fly   249 VVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLH 313

  Fly   251 WLAWYTKSMLLL-----LLCLLIMISIFSIGLIYEFSSLVCLMTIFLVYIHSLVLFAFFISSFFS 310
            |.||:.||.::|     |:.:|:.|:......:...::...|:...::||.|.:.|.|.:::|||
  Fly   314 WTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFS 378

  Fly   311 RSLSAVVATILMYFSTALP--FLIVGAENSSVAAQTAASIGLNSALFYILDSVAVMEMQSVGAQW 373
            |:.:|...|.|::|...:|  |.|...::.|::::...|:..|:|:.:.:..:...|....|.||
  Fly   379 RASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQW 443

  Fly   374 YTIDNTASSGYKLSIVGYMLIMISISWIELLICLYIEAVRTGEFEVPQPWSYPFQRRYWCPLRYG 438
            .......|....|::...|::|:....|.::||||:|.|..|.|.||:||::||.|.:||..|..
  Fly   444 SNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGEREY 508

  Fly   439 SSVFHQGALLPLAGKNSEGNLPAAHPTRQPIIYLDDRTQENFQRVNISKKIGIEVRSLSKTFGFR 503
            :.|               .::|..|        ::.|..:.|:.....|.||:::|.|.|.||.:
  Fly   509 TGV---------------EDIPNGH--------VEQRDPKAFETEPEGKHIGLQMRHLKKRFGNK 550

  Fly   504 NVVKDLFFNVYENEITALVGHKGSGKTTIIMMLCGILQPTTGTVLINGYDIVTEAKVAKSSLGIC 568
            .|||.|..|::|:|||.|:||.|:||||.|.||.|:..||:||.:|||.||.|..:.|:.|||||
  Fly   551 MVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGIC 615

  Fly   569 PQHSVIFKGMSARDHIYFFSRVKGYNKTEAMMESNIYISKLGLVDSQKWDAMRLSPGNQRRLSLA 633
            |||:|:|..||..:||.||||:||........|...|:..:.|.|.....:.:||.|.:|:||:.
  Fly   616 PQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVC 680

  Fly   634 CALCAGSKVILCDEPSSGLDPIGRHELMRFLQKEKHGRTILMTTQQLEEGEILADRIAIMNDGQI 698
            ||||..:||:||||||||:||..|.:|...||:||.|||:|:||..::|.::|.||||||.||::
  Fly   681 CALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGEL 745

  Fly   699 LCYGTLGYLKQLPFTSYTLSCQMAPNSKADNLTDLVRLYMTTTTSPVFHGVDVSYKLPRSQIDRF 763
            .|.||..:||:...:.|.|.|....:.:.:.:|.|:..|:.........|.::||:||.|...:|
  Fly   746 KCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAKF 810

  Fly   764 PEFFQQLEENKKSLNVVSFGVSDSTLDGIYLSLDYGQGSSRLRGGADPGVNDKVEFGVQTDKAIR 828
            .|.|.||||....|::..:||..::::.:::.:           ||:
  Fly   811 EEMFGQLEEQSDELHLNGYGVGITSMEEVFMKV-----------GAE------------------ 846

  Fly   829 TKDRANNSLVRYQHQV---------DPPNETILN------TKTPINPIEIWRPIDREKGSCMAQW 878
             ||...|  ::.||::         :..||::.:      .:..:..:::          ...||
  Fly   847 -KDNTGN--IKDQHEIMNGGSGFRGEDDNESVQSDGIFSENRRLLQGLQL----------LSNQW 898

  Fly   879 QAMFIKKKNYTASRALIFILILIIPLFYYIIVL------GTAASEKCAHRTDKQPVLPLSLDYYS 937
            :||.:||..||....|:.::..|:|:|:.::.:      ||.           |.:.|:::....
  Fly   899 KAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTF-----------QELKPITISLTQ 952

  Fly   938 YDDMIILLEVD--------------KQLYKSEGEAY-VQLVKEPATVESVDSIFSHLLKAPPIIR 987
            |...:.:|:..              :.|.:|.|..| ::|.       .......::|.....|:
  Fly   953 YPLAVTVLDRSNVQNGTGYEIANKYEDLARSYGSNYGLELT-------GTQGFEDYILDLGKTIQ 1010

  Fly   988 RDIKRKYVCGASFNNASTITAWFNSDAFEHSAPIALNLVYNALGKAVFEDQDFSILVNRGDLHDF 1052
            ..|..:|:..|:... |.||||.|:.|. |:||:.:|:|:||:...:|.
  Fly  1011 VRINSRYLVAATITE-SKITAWLNNQAL-HTAPLTVNMVHNAIADKLFG---------------- 1057

  Fly  1053 IWLNNASSMRRRYKRQNDPDYTDYSDYEIQEYDVVVKPNSSSTSGQHNKSNPGDDNIITVQMSII 1117
                                    |..:||   |...|...:||                  :::
  Fly  1058 ------------------------SSVKIQ---VTNAPLPYTTS------------------TLL 1077

  Fly  1118 EAASTLYNEKGKRKQLFGTLIIITAYIALCL--SIFSIFVTKERVEHFKMQQEIYGVTLFYFWST 1180
            ...||..|        .||.:.......:|.  ||:.:|:.|||....|:.|.:.||.::.||.:
  Fly  1078 SQLSTGNN--------LGTQLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLS 1134

  Fly  1181 HFVGDFLIYAI--YMGALTIAIYHFT---------IWYQVVVMLLLIGFACLPFVYLCSLLFSLP 1234
            .|:.||..|.:  .:..:||..:..|         .:|   ::|||.|||.|||:|:.||.|..|
  Fly  1135 QFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYY---LLLLLFGFAVLPFIYIMSLFFREP 1196

  Fly  1235 NIAFAGIFAILVMTGGMLFSFMYMLTL-ITDVNFTT-----VFAILPMYVGTFGLFKC---LAWR 1290
            ...||.:..:.:..|..||..:.:::. :.|...|.     :|.|.|.:.....|.|.   .|.|
  Fly  1197 ATGFARVSIVNIFCGMALFIVVVVMSSELFDTKDTADILGWIFRIFPHFSLAMSLNKVYTNTATR 1261

  Fly  1291 EYCNRE-VLPPIEELDCKF-GNCNVFCACKPERTWMEVWLL------MVHCLVWFIFLWFSNFGY 1347
            ..|.:. .||||  |.|:. ..|   |..||...|.|..:|      .|..:|:|:.:....|..
  Fly  1262 NACAKAGALPPI--LLCELVPQC---CNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRL 1321

  Fly  1348 --EIGYRFKPKLSNRIWHNNEKHI--RVLDEERRVGLIPKYEHEDYPIIVDQVTKNYCRAKNAVQ 1408
              |:.::.:..:|.......|..:  .|.:|..|:..:...|.....:::|:|||.|.:.. ||.
  Fly  1322 INELMFKIRQLISKPPPPPTEGQLDDDVANERERILQMSSNELATKNLVLDRVTKYYGQFM-AVN 1385

  Fly  1409 LVSFAIRPGDTFGLLGAQGAGKTSIFQMIAGETSMSHGNIYVRGHSLREHRNAAKMEVGFCPQGD 1473
            .||..::..:.|||||..|||||:.|:|:.|:..:|.|..||:|.||..:.|:....:|:|||.|
  Fly  1386 QVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFD 1450

  Fly  1474 NAPKYLTGRQLLRIHCLLHGVPKDHIKAVSEQMAIEFNFKDQLDRPIHTYSGGKKRKLNIALA-I 1537
            .....||||::|||.|:|.||.:..|:.:||.:|..|.|...:|:..|.||||.||||:.|:| |
  Fly  1451 ALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVI 1515

  Fly  1538 DSGSVLCLDDTNGSVDHATQRFIWRKLEAVKRSGRPVLLTTQSMEEANAVCSRVAFLVAGEMMFI 1602
            .|.||:.||:....:|.|.:|.:|..:..::.||:.::||:.||||..|:|:|:|.:|.||...|
  Fly  1516 GSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCI 1580

  Fly  1603 GSLQQVRSEVSNTIVIRLRV------------------NPSDGKLKRRFQQLIADMAELF----- 1644
            ||.|.::::.|..::::::|                  ||.:..:..:..|...|..:.|
  Fly  1581 GSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEY 1645

  Fly  1645 PLATLHEALETCLIYHININVTTLANLFYQMEKIRNEGLLEDYSITQVSLDEIY 1698
            |.:.|.|..:..|.::|.:.....:.:|..||..|::..:||||::|.:|:||:
  Fly  1646 PNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIF 1699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31213	NP_001262752.1	ABC2_membrane_3	32..>295	CDD:289468	68/346 (20%)
		ABC_subfamily_A	491..708	CDD:213230	108/216 (50%)
		drrA	498..796	CDD:130256	130/297 (44%)
		ABC2_membrane_3	<1132..1285	CDD:289468	48/171 (28%)
		CcmA	1391..1672	CDD:224054	105/304 (35%)
		ABC_subfamily_A	1391..1609	CDD:213230	93/218 (43%)
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	54/179 (30%)
		ABC2_membrane_3	<269..475	CDD:289468	59/205 (29%)
		CcmA	538..843	CDD:224054	132/304 (43%)
		ABC_subfamily_A	538..755	CDD:213230	108/216 (50%)
		ABC2_membrane_3	913..1316	CDD:289468	113/499 (23%)
		ABC_subfamily_A	1369..1587	CDD:213230	93/218 (43%)
		drrA	1376..1702	CDD:130256	114/325 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451230
Domainoid	1	1.000	97	1.000	Domainoid score	I371
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I138
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm51427
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
	9	9.000