DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31213 and Abca1

DIOPT Version :9

Sequence 1:NP_001262752.1 Gene:CG31213 / 42382 FlyBaseID:FBgn0051213 Length:1809 Species:Drosophila melanogaster
Sequence 2:XP_038965774.1 Gene:Abca1 / 313210 RGDID:631344 Length:2263 Species:Rattus norvegicus


Alignment Length:2035 Identity:481/2035 - (23%)
Similarity:830/2035 - (40%) Gaps:520/2035 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 KLQLTNWVELVMIIFLSALMPIFFSIGTKVAKSIFPPDIEMEKSPGPKSVNTSLFV--DLYFTPN 82
            ||...:|....::.||              ||:  |.|::        |.|.|::.  :.:...|
  Rat   452 KLDGLDWTAQDIMAFL--------------AKN--PEDVQ--------SPNGSVYTWREAFNETN 492

  Fly    83 NGILEQLITQLANISEFKSVEVFDTNSELY---LQLMINRNA-IGIAFPSEWYDIKSCPEVLNLT 143
            ..|  |.|::.........:|...|...|.   ::|:..|.. .||.|.....|....|..:...
  Rat   493 QAI--QTISRFMECVNLNKLEPIPTEVRLINKSMELLDERKFWAGIVFTGITPDSVELPHHVKYK 555

  Fly   144 IFMPL-SIKR------------------KDFKYFESGFLLLQERISKIFIFFKNAGNGKIPRVLM 189
            |.|.: :::|                  :|.:|...||..||:.:.:..|... .|..|...|.:
  Rat   556 IRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVL-TGTEKKTGVYV 619

  Fly   190 NHFPYPSYVPNHYAE-SAKAMTYMTLISFFLPCITIAKYVVAEKERHQKAVLTAMGFSNSIHWLA 253
            ...|||.||.:.:.. .:::|.....:::......|.|.:|.|||...|..:..||..|.|.|.:
  Rat   620 QQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKSIVYEKEARLKETMRIMGLDNGILWFS 684

  Fly   254 WYTKSMLLLLLCLLIMISIFSIGLIYEFSSLVCLMTIFLVYIHSLVLFAFFISSFFSRSLSAVVA 318
            |:..|::.||:...:::.|..:|.:..:|....:.....|:....:|..|.||:.|||:..|...
  Rat   685 WFISSLIPLLVSAGLLVIILKLGDLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRTNLAAAC 749

  Fly   319 TILMYFSTALPFLIVGAENSSV--AAQTAASIGLNSALFYILDSVAVMEMQSVGAQWYTIDNTAS 381
            ..::||:..||:::..|....|  :.:..||:....|..:..:..|:.|.|.:|.||   ||...
  Rat   750 GGIIYFTLYLPYVLCVAWQDYVGFSIKIFASLLSPVAFGFGCEYFALFEEQGIGVQW---DNLFK 811

  Fly   382 S-----GYKLSIVGYMLIMISISWIELLICLYIEAVRTGEFEVPQPWSYPFQRRYWCPLRYGSSV 441
            |     |:.|:.  .:.:|:..::|..::..|||||..|::.:|:||.:|..:.||    :|..:
  Rat   812 SPVEEDGFNLTT--SVSMMLFDTFIYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYW----FGEEI 870

  Fly   442 ---FHQGALLPLAGKNSEGNLPAAHPTRQPIIYLDDRTQENFQRVNISKKIGIEVRSLSKTF--G 501
               .|.|:    :.|.:........||.                    .|:|:.:::|.|.:  |
  Rat   871 DEKSHPGS----SQKGASEICMEEEPTH--------------------LKLGVSIQNLVKVYRDG 911

  Fly   502 FRNVVKDLFFNVYENEITALVGHKGSGKTTIIMMLCGILQPTTGTVLINGYDIVTEAKVAKSSLG 566
            .:..|..|..|.||.:||:.:||.|:||||.:.:|.|:..||:||..|.|.||.:|....:.:||
  Rat   912 MKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMNSIRQNLG 976

  Fly   567 ICPQHSVIFKGMSARDHIYFFSRVKGYNKTEAMMESNIYISKLGLVDSQ-KWDAMRLSPGNQRRL 630
            :||||:|:|..::..:||:|::|:||.::.....|.......:||..|: |....:||.|.||:|
  Rat   977 VCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPPSKLKSKTSQLSGGMQRKL 1041

  Fly   631 SLACALCAGSKVILCDEPSSGLDPIGRHELMRFLQKEKHGRTILMTTQQLEEGEILADRIAIMND 695
            |:|.|...||||::.|||::|:||..|..:...|.|.:.||||:::|..::|.:||.|||||::.
  Rat  1042 SVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISH 1106

  Fly   696 GQILCYGTLGYLKQLPFTSY---------------------TLSC--QMAPNSKA---------- 727
            |::.|.|:..:||....|.|                     |:||  ::.|...|          
  Rat  1107 GKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSCLKKVVPELPAAGQSGGRGGE 1171

  Fly   728 -----------DNLTDLVRLYMTTTTSPVFHGVDVSYKLP--RSQIDRFPEFFQQLEENKKSLNV 779
                       ..:::|:|.:::........|.:::|.||  .::...|.|.|.::::....|.:
  Rat  1172 VQRLVALTQDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGI 1236

  Fly   780 VSFGVSDSTLDGIYLSLDYGQG-SSRLRGGADPGVNDKVEFGVQTDKAI----RTKDRANNSLVR 839
            .|:|:|::||:.|:|.:....| .:....|..|...::..||   ||..    .|:|.|      
  Rat  1237 SSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFG---DKQSCLHPFTEDDA------ 1292

  Fly   840 YQHQVDPPNETILNTKTPINPIEIWRPIDRE---------KGSCMAQ-------------WQAMF 882
                || ||::.|:            |..||         |||...:             |:.:.
  Rat  1293 ----VD-PNDSDLD------------PESRETDLLSGMDGKGSYQLKGWKLTQQQFVALLWKRLL 1340

  Fly   883 I---KKKNYTASRAL--IFILI-----LIIPLFYYIIVLGTAASEKCAHRTDKQPVLPLSLDYYS 937
            |   .:|.:.|...|  :|:.|     ||:|.|                  .|.|  .|.|..:.
  Rat  1341 IARRSRKGFFAQIVLPAVFVCIALVFSLIVPPF------------------GKYP--NLELQPWM 1385

  Fly   938 YDDMIILLEVDKQLYKSEGEAYVQLVKEPA----------------------------------- 967
            |::....:..|........|....|.|:|.                                   
  Rat  1386 YNEQYTFVSNDAPEDMGTQELLNALTKDPGFGTRCMEGNPIPNTPCLVGEEDWTTGPVPQTLMDL 1450

  Fly   968 ------TVE--------SVDSIFSHLLKAPP---------------------------------- 984
                  |::        |.|.|...|...||                                  
  Rat  1451 FQNGNWTMKNPSPSCQCSSDKIKKMLPVCPPGAGGLPPPQRKQKTADILQNLTGRNISDYLVKTY 1515

  Fly   985 --IIRRDIKRK----------YVCGAS----------FNNA------------------------ 1003
              ||.:.:|.|          :..|.|          .|||                        
  Rat  1516 VQIIAKSLKNKVWVNEFRYGGFSLGVSDSQALPPSQEVNNAIKQMKKLLKLTKDSSADRFLSSLG 1580

  Fly  1004 ---------STITAWFNSDAFEHSAPIALNLVYNALGKAVFEDQDFSILVNRGDLHDFIWLNNAS 1059
                     :.:..|||:..: |:....||::.||:                             
  Rat  1581 RFMTGLDTKNNVKVWFNNKGW-HAISSFLNVINNAI----------------------------- 1615

  Fly  1060 SMRRRYKRQNDPDYTDYSDYEIQEYDVVVKPNSSSTSGQHNKSNPGDDNIITVQMSIIEAASTLY 1124
             :|...::..:|     |.|.|..::..:                   |:...|:|.:...:|..
  Rat  1616 -LRANLQKGENP-----SQYGITAFNHPL-------------------NLTKQQLSEVALMTTSV 1655

  Fly  1125 NEKGKRKQLFGTLIIITAYIALCLSI----FSIFVTKERVEHFKMQQEIYGVTLFYFWSTHFVGD 1185
            :            ::::..:...:|.    |.:|:.:|||...|..|.|.||....:|.::||.|
  Rat  1656 D------------VLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFICGVKPVIYWLSNFVWD 1708

  Fly  1186 FLIYAIYMGALTIAIYHFTIWYQ-----------VVVMLLLIGFACLPFVYLCSLLFSLPNIAFA 1239
            ...|.:   ..|:.:..|..:.|           :.::|||.|::..|.:|..|.:|.:|:.|:.
  Rat  1709 MCNYVV---PATLVVIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYV 1770

  Fly  1240 GIFAILVMTG--GMLFSFMYMLTLIT-----DVN--FTTVFAILPMYVGTFGLFKCLAWREYCNR 1295
            .:.::.:..|  |.:.:|  :|.|.|     |:|  ..:||.|.|.:....||...:.     |:
  Rat  1771 VLTSVNLFIGINGSVATF--VLELFTNNKFNDINDILKSVFLIFPHFCLGRGLIDMVK-----NQ 1828

  Fly  1296 EVLPPIEELDCKFGNCNVFCACKPERTWMEVWLLMVHCLVWFIFLWFSNFGYEIGYRF--KPK-L 1357
            .:...:|    :||..........:.....::.:.|..:|:|:....      |.|||  :|: :
  Rat  1829 AMADALE----RFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLVTVL------IQYRFFIRPRPV 1883

  Fly  1358 SNRIWHNNEKHIRVLDEERRV----GLIPKYEHEDYPIIVDQVTKNYCR-AKNAVQLVSFAIRPG 1417
            ..|:...|::...|..|.:|:    |       ::..:.:.::||.|.| .|.||..:...|.||
  Rat  1884 KARLPPLNDEDEDVRRERQRILEGGG-------QNDILEIKELTKIYRRKRKPAVDRICVGIPPG 1941

  Fly  1418 DTFGLLGAQGAGKTSIFQMIAGETSMSHGNIYVRGHSLREHRNAAKMEVGFCPQGDNAPKYLTGR 1482
            :.|||||..||||||.|:|:.|:|:::.|:..:..:|:..:.:.....:|:|||.|...:.||||
  Rat  1942 ECFGLLGVNGAGKTSTFKMLTGDTAVTRGDALLNKNSILSNIHEVHQNMGYCPQFDAITELLTGR 2006

  Fly  1483 QLLRIHCLLHGVPKDHIKAVSEQMAIEFNFKDQLDRPIHTYSGGKKRKLNIALAIDSG-SVLCLD 1546
            :.|....||.|||:..:..|.|....:.......::....||||.||||:.|:|:..| .|:.||
  Rat  2007 EHLEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYASNYSGGNKRKLSTAIALIGGPPVVFLD 2071

  Fly  1547 DTNGSVDHATQRFIWRKLEAVKRSGRPVLLTTQSMEEANAVCSRVAFLVAGEMMFIGSLQQVRSE 1611
            :....:|...:||:|....::.:.||.|:||:.||||..|:|:|:|.:|.|....:||:|.:::.
  Rat  2072 EPTTGMDPKARRFLWNCALSIIKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNR 2136

  Fly  1612 VSN--TIVIRLRVNPSDGKLKRRFQQLIADMAELFPLATLHEALETCLIYHININVTTLANLFYQ 1674
            ..:  |||:|:..:..|.|..:.|..|      .||.:.|.|.....|.|.:..::::||.:|..
  Rat  2137 FGDGYTIVVRIAGSNPDLKPVQEFFGL------AFPGSVLKEKHRNMLQYQLPSSLSSLARIFSI 2195

  Fly  1675 MEKIRNEGLLEDYSITQVSLDEIY-RILNDE-EDPNLVDLDSTHNSEVLEDIRDTTRDTTRGTTR 1737
            :.:.:....:||||::|.:||::: ....|: :|.:|.|| |.|.::.:.|:             
  Rat  2196 LSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDL-SLHKNQTVVDV------------- 2246

  Fly  1738 DTNLVSDEGIQKEKVKRKKV 1757
               .|....:|.||||...|
  Rat  2247 ---AVLTSFLQDEKVKESYV 2263

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31213NP_001262752.1 ABC2_membrane_3 32..>295 CDD:289468 62/288 (22%)
ABC_subfamily_A 491..708 CDD:213230 85/219 (39%)
drrA 498..796 CDD:130256 110/346 (32%)
ABC2_membrane_3 <1132..1285 CDD:289468 43/176 (24%)
CcmA 1391..1672 CDD:224054 96/284 (34%)
ABC_subfamily_A 1391..1609 CDD:213230 80/219 (37%)
Abca1XP_038965774.1 rim_protein 1..2238 CDD:130324 472/1992 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.930

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