DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31213 and Abca4

DIOPT Version :9

Sequence 1:NP_001262752.1 Gene:CG31213 / 42382 FlyBaseID:FBgn0051213 Length:1809 Species:Drosophila melanogaster
Sequence 2:NP_001101191.1 Gene:Abca4 / 310836 RGDID:1309445 Length:2290 Species:Rattus norvegicus


Alignment Length:1994 Identity:473/1994 - (23%)
Similarity:806/1994 - (40%) Gaps:462/1994 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 NRNLTY--CQKYRLLL--WKDIKLQLTNWVELVMIIFLSALMPIFFSIGTKVA---KSIFPPDIE 59
            |.|.|:  ..:.|.|:  |:::..|:  |              .||...|::|   .::..|.::
  Rat   394 NANSTFEELDRVRKLVKAWEEVGPQI--W--------------YFFEKSTQMAVIRDTLQHPTVK 442

  Fly    60 --MEKSPGPKSVNTSLFVDLYFTPNN------------------GILEQLITQLAN-------IS 97
              :.:..|.:.:.|...  |.|.||.                  .|.::.: :|||       :.
  Rat   443 DFINRQLGEEGITTEAI--LNFFPNGPRENQADDMTSFDWRDIFNITDRFL-RLANQYLECLVLD 504

  Fly    98 EFKSV--EVFDTNSELYLQLMINRNAIGIAFPSEWYDIKSCPEVLNLTIFMPLSIKRK------- 153
            :|:|.  ||..|...|.| |..||...|:.||..:....|.|..:...|.|.:.:..|       
  Rat   505 KFESYDDEVQLTQRALSL-LEENRFWAGVVFPDMYPWTSSLPPHVKYKIRMDIDVVEKTNKIKDR 568

  Fly   154 ------------DFKYFESGFLLLQERISKIFIFFKNAGNGKIPRVLMNHFPYPSYVPNHYAESA 206
                        ||:|...||..||:.:.:..:..:......| .|.:...|||.:|.:      
  Rat   569 YWDSGPRADPVEDFRYIWGGFAYLQDMVEQGIVRSQTPAEPPI-GVYLQQMPYPCFVDD------ 626

  Fly   207 KAMTYMTLISFFLPCITI----------AKYVVAEKERHQKAVLTAMGFSNSIHWLAWYTKSMLL 261
               ::|.:::...|...:          .|.:|.|||...|..|...|.||::.|..|:..|..:
  Rat   627 ---SFMIILNRCFPIFMVLAWIYSVSMTVKGIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSI 688

  Fly   262 LLLCLLIMISIFSIGLIYEFSSLVCLMTIFLVYIHSLVLFAFFISSFFSRSLSAVVATILMYFST 326
            :.:.:.::......|.|..:|....|....|.:..:.::..|..|:|||::..|...:.::||:.
  Rat   689 MSMSIFLLTLFIMHGRILHYSDPFILFLFLLAFATATIMQCFLFSTFFSKASLAAACSGVIYFTL 753

  Fly   327 ALPFLIVGAENSSVAAQTAASIGLNS--ALFYILDSVAVMEMQSVGAQWYTIDNTASSGYKLSIV 389
            .||.::..|....:.|....::.|.|  |..:..:.:...|.|.:|.||..|..:...|.:.|.:
  Rat   754 YLPHILCFAWQDRMTADLKTTVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGKSPLEGDEFSFL 818

  Fly   390 GYMLIMISISWIELLICLYIEAVRTGEFEVPQPWSYPFQRRYWCPLRYGSSVFHQGALLPLAGKN 454
            ..|.:|:..:.:..|:..|::.|..|::..|.||.:..|..||.. ..|.|...:.||       
  Rat   819 LSMKMMLLDAALYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLG-GEGCSTREERAL------- 875

  Fly   455 SEGNLPAAHPTRQPIIYLDDRTQENFQRVNISKKIGIEVRSLSKTF--GFRNVVKDLFFNVYENE 517
             |...|.......| .|.:|   ..|:|.......|:.|::|.|.|  |.|..|..|....|||:
  Rat   876 -EKTEPLTEEIEDP-EYPED---SFFERELPGLVPGVCVKNLVKVFEPGSRPAVDRLNITFYENQ 935

  Fly   518 ITALVGHKGSGKTTIIMMLCGILQPTTGTVLINGYDIVTEAKVAKSSLGICPQHSVIFKGMSARD 582
            |||.:||.|:||||.:.:|.|:|.||:|||||.|.||.......:.|||:||||:::|..::..:
  Rat   936 ITAFLGHNGAGKTTTLSILTGLLPPTSGTVLIGGKDIEISLDAVRQSLGMCPQHNILFHHLTVAE 1000

  Fly   583 HIYFFSRVKGYNKTEAMMESNIYISKLGLVDSQKWDAMRLSPGNQRRLSLACALCAGSKVILCDE 647
            ||.|::::||.:..||.:|....:...||...:..:|..||.|.||:||:|.|....|||::.||
  Rat  1001 HILFYAQLKGRSWEEARLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDSKVVVLDE 1065

  Fly   648 PSSGLDPIGRHELMRFLQKEKHGRTILMTTQQLEEGEILADRIAIMNDGQILCYGTLGYLKQLPF 712
            |:||:||..|..:...|.|.:.||||:|:|..::|.::|.|||||::.|::.|.||..:||....
  Rat  1066 PTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIISQGRLYCSGTPLFLKNCFG 1130

  Fly   713 TSYTLS--------------CQMAPN-----------SKADNLT-------DLVRLYMTTTTSPV 745
            |.:.|:              |:.|.:           ::.|.:|       |:..|     |..|
  Rat  1131 TGFYLTLVRKMKNIQSQRCGCEGACSCTSKGFSARCPARVDEITEEQVLDGDVKEL-----TDLV 1190

  Fly   746 FH-----------GVDVSYKLPRSQIDR--FPEFFQQLEENKKSLNVVSFGVSDSTLDGIYLSL- 796
            :|           |.::.:.||.....:  :...|::|||....|.:.|||:||:.|:.|:|.: 
  Rat  1191 YHHVPEAKLVECIGQELIFLLPNKNFKQRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVT 1255

  Fly   797 DYGQGSSRLRGGAD-----PGVNDKVEFGVQTDKAIRTKDRANNSLVRYQHQVDPPNETILNTKT 856
            :..:..|:..||..     .|:.......|:     :.:..|..|......|||||.    ...:
  Rat  1256 EDSESGSKFVGGTQQKREHTGLRHPCSAPVE-----KHRQHAQASHTCSPGQVDPPK----GQPS 1311

  Fly   857 PINPIEIWRPIDREKGSCMAQWQAMFIKKKNYTASRALIFILILIIPLFYYIIVL---------- 911
            | .|.:...|.:......:...||:.:|:.::.......|:..:::|..:..:.|          
  Rat  1312 P-EPEDPGIPFNTGARLILQHVQALLVKRFHHAVRSRKDFVAQIVLPATFVFLALMLSIIVPPFG 1375

  Fly   912 ---------------------------------------------------------GTAASEK- 918
                                                                     |.|.|.| 
  Rat  1376 EFPALTLHPWMYGHQFTFFSMDEPNNEHLEVLADVLLNRPGFGNRCLKEEWLPEYPCGNATSWKT 1440

  Fly   919 ------CAHRTDKQ--------PVLPLSLDYYSYDDMIILLEVDK--------QLYKSEGEAYVQ 961
                  ..|...||        |....|    :.:.:|:|.|..:        |..:...|....
  Rat  1441 PSVSPNITHLFQKQKWTAAHPSPACKCS----TREKLIMLPECPEGAGGLPPPQRIQRSTEVLQD 1501

  Fly   962 LVKEPATVESVDSIFSHLLKA-PPIIRRDIKRKYVCGASFNNASTITAWFNSDAFE--------H 1017
            |...        :|..:|:|. |.:||..:|.|:              |.|...:.        .
  Rat  1502 LTNR--------NISDYLVKTYPALIRSSLKSKF--------------WVNEQRYGGISIGGKLP 1544

  Fly  1018 SAPIA----------LNLVYNALGKAVFEDQDFSILVNRGDLHDF-----------IWLNNA--- 1058
            ..||:          |..:.|..|..|..:....:|       ||           :|.||.   
  Rat  1545 DIPISGEALVGFLSDLGQMMNVSGGPVTRESSREML-------DFLKHLETKDNIKVWFNNKGWH 1602

  Fly  1059 -----------SSMRRRYKRQNDPDYTDYSDYEIQEYDVVVKPNSSSTSGQHNKSNPGDDNIITV 1112
                       :.:|....:..||          :||.:.|            .|.|  .|:...
  Rat  1603 ALVSFLNVAHNAILRASLPKDRDP----------EEYGITV------------ISQP--LNLTKE 1643

  Fly  1113 QMSIIEAASTLYNEKGKRKQLFGTLIIITAYIALCL--------SIFSIFVTKERVEHFKMQQEI 1169
            |:|.|...:|                .|.|.:|:|:        :.|.:::.:|||...|..|.|
  Rat  1644 QLSEITVLTT----------------SIDAVVAICVIFAMSFVPASFVLYLIQERVTKAKHLQFI 1692

  Fly  1170 YGVTLFYFWSTHFVGDFLIYAIYMGALTIAIYHFTIWYQ------------VVVMLLLIGFACLP 1222
            .||:...:|.|:|:.|.:.||:..| |.:.|:   |.:|            :|.:|:|.|:|.:|
  Rat  1693 SGVSPTTYWMTNFLWDIMNYAVSAG-LVVGIF---IGFQKKAYTSTDNLPALVTLLMLYGWAVIP 1753

  Fly  1223 FVYLCSLLFSLPNIAFAGIFAILVMTGGMLFSFMYMLTLITDVNFTTVF-AILPMYVGTFGLFKC 1286
            .:|..|.||.:|:.|:..:....:..|....:..::|.|..:......| |.|...:..|..| |
  Rat  1754 MMYPASFLFDVPSTAYVALSCANLFIGINSSAITFVLELFENNRMLLRFSATLRELLIVFPHF-C 1817

  Fly  1287 LAWREYCNREVLPPIEELDCKFG---NCNVFCACKPERTW----MEVWLLMVHCLVWFIFLWFSN 1344
            |. |...:..:...:.::..:||   :.|.|       .|    ..:..:.:..:|:|:....  
  Rat  1818 LG-RGLIDLALSQAVTDIYAQFGEEYSANPF-------QWDLIGKNLVAMAIEGVVYFLLTLL-- 1872

  Fly  1345 FGYEIGYRFKPKLSNRIWHNNEKHIRVLDE-----ERRVGLIPKYEHEDYPIIVDQVTKNYCRAK 1404
                |.:.|   ...| |........|.||     |.|..::......|. :.::::||.|..:.
  Rat  1873 ----IQHHF---FLTR-WIAEPAREPVFDEDDDVAEERQRVMSGGSKSDI-LKLNELTKVYSGSS 1928

  Fly  1405 N-AVQLVSFAIRPGDTFGLLGAQGAGKTSIFQMIAGETSMSHGNIYVRGHSLREHRNAAKMEVGF 1468
            : ||..:...:.||:.|||||..|||||:.|:|:.|:|:::.|:..:.|.|:..:.:.....:|:
  Rat  1929 SPAVDRLCVGVHPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATIAGKSILTNISDVHQNMGY 1993

  Fly  1469 CPQGDNAPKYLTGRQLLRIHCLLHGVPKDHIKAVSEQMAIEFNFKDQLDRPIHTYSGGKKRKLNI 1533
            |||.|.....||||:.|.::..|.|||...|:.|:.............||...|||||.||||:.
  Rat  1994 CPQFDAIDDLLTGREHLYLYARLRGVPSKEIEKVANWGIQSLGLSLYADRLAGTYSGGNKRKLST 2058

  Fly  1534 ALAIDS-GSVLCLDDTNGSVDHATQRFIWRKLEAVKRSGRPVLLTTQSMEEANAVCSRVAFLVAG 1597
            |:|:.. ..:|.||:....:|...:|.:|..:..:.|.||.|:||:.||||..|:|:|:|.:|.|
  Rat  2059 AIALTGCPPLLLLDEPTTGMDPQARRMLWNTIVNIIRQGRAVVLTSHSMEECEALCTRLAIMVKG 2123

  Fly  1598 EMMFIGSLQQVRSEVSNTIVIRLRV-NPSDGKLKRRFQQLIADMAEL-------FPLATLHEALE 1654
            ....:|::|.::.:..:..::.::: :|.|        .|:.|:..:       ||.:...|...
  Rat  2124 TFQCMGTIQHLKYKFGDGYIVTMKIKSPKD--------DLLPDLNPVEQFFQGNFPGSVQRERHH 2180

  Fly  1655 TCLIYHININVTTLANLFYQMEKIRNEGLLEDYSITQVSLDEIY 1698
            :.|  ...:..::||.:|..:...::..|:|:||:||.:||:::
  Rat  2181 SML--QFQVPSSSLARIFQLLISHKDSLLIEEYSVTQTTLDQVF 2222

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31213NP_001262752.1 ABC2_membrane_3 32..>295 CDD:289468 66/323 (20%)
ABC_subfamily_A 491..708 CDD:213230 92/218 (42%)
drrA 498..796 CDD:130256 119/344 (35%)
ABC2_membrane_3 <1132..1285 CDD:289468 43/173 (25%)
CcmA 1391..1672 CDD:224054 87/290 (30%)
ABC_subfamily_A 1391..1609 CDD:213230 77/219 (35%)
Abca4NP_001101191.1 rim_protein 1..2249 CDD:130324 473/1994 (24%)
ABC_subfamily_A 907..1126 CDD:213230 92/218 (42%)
ABC_subfamily_A 1915..2135 CDD:213230 77/219 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166342251
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.860

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