DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31213 and Abca8a

DIOPT Version :9

Sequence 1:	NP_001262752.1	Gene:	CG31213 / 42382	FlyBaseID:	FBgn0051213	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	NP_001268753.1	Gene:	Abca8a / 303638	RGDID:	1307333	Length:	1615	Species:	Rattus norvegicus

Alignment Length:	1898	Identity:	430/1898 - (22%)
Similarity:	773/1898 - (40%)	Gaps:	498/1898 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNRNLTYCQKYRLLLWKDI--KLQL---TNWVELVMIIFLSALMPIFFSIGTKVAKSIFPPDIEM 60
            :.|.:...|:...||.|::  |.:|   |.| ||:...|:...:.:||.:......|.. .|:::
  Rat     2 VKREINVWQQTWALLCKNLLRKKRLKRDTLW-ELLYTAFILLCLSLFFELHDVYEFSSL-SDVDL 64

  Fly    61 EKSPGPKSVNTSLFVDLYFTPNNGILEQLITQLANISEFKSVEVFDTNSELYLQLMINR---NAI 122
            .:   ..|.|.|.|. :.:||.....::::.:::.:|.....|:....::..:...|::   :|:
  Rat    65 GR---VDSFNDSTFA-IAYTPVTPTTQEIMNRVSLVSYMTGREILAFPNKENMTEFISKHYDDAV 125

  Fly   123 GIAFPSEW-YDIKSCPEVLNLTIFM-----PLSIKRKD-----FKY-----------FESGFLLL 165
            ||.|.:.: |.:|          ||     |:..:.:|     |:|           :..||:.|
  Rat   126 GIIFSTAYSYHLK----------FMKGTRIPIIKEHQDHTAHCFRYEPAISCDLSAFWRHGFVAL 180

  Fly   166 QERISKIFIFFKNAGNGKIPRVLMNHFPYPSYVPNHYAESAKAMT--YMTLISF----------- 217
            |..|           |..|..|..||         ...|...::|  |:.:.||
  Rat   181 QAAI-----------NSAIIEVTTNH---------SVMEEMMSLTGKYIKIDSFIAQEGTTTDYF 225

  Fly   218 -FLPCI----TIAKYV---VAEKERHQKAVLTAMGFSNSIHWLAW-YTKSMLLLLLCLLIMISIF 273
             || ||    .:..|:   |..:.:..||.:|.||..:|..||:| ....:::.::.|.:...::
  Rat   226 LFL-CIIAFSPLTYYISAGVTRERKKMKAFMTVMGLRDSAFWLSWGLLYGVIVFIVTLFLTFVVY 289

  Fly   274 SIGLIYEFSSLVCLMTIFLVYIHSLVLFAFFISSFFSRSL--------------SAVVATILMYF 324
            |:..:: .:..:.:.::|..|..||:..:|.:|....:|.              |...|.:..|.
  Rat   290 SVQFVF-MTGFMMIFSLFFFYGLSLISLSFLMSVLLKKSFLTDLVVFFLTVSCGSLGFAALYRYL 353

  Fly   325 STALPFLIVGAENSSVAAQTAASIGLNSALFYILDSVAVMEMQSVGAQWYTIDNTASSGYKLS-- 387
            ..:|.:|:      |:.:..|..:|:...|  .||              |.::   |||:...
  Rat   354 PVSLEWLL------SLLSPFAFMLGMTQLL--RLD--------------YDLE---SSGHPTGNP 393

  Fly   388 --IVGYMLIMISISWIELLICLYIEAVRTGEFEVPQPWSYPFQRRYWCPLRYGSSVFHQGALLPL 450
              ::..:.::.......|::..|.|.|..||:....|..:..:..:|
  Rat   394 NVVIATVFLLFFDGVFYLMLTFYFEKVLPGEYGRRHPPLFFLKSSFW------------------ 440

  Fly   451 AGKNSEGNLPAAHPTRQPIIYLDDRT-----------QENFQRVNI---SKKIGIEVRSLSKTFG 501
            .|:|     ||            |||           .::|:.|:.   .|:: |.:|:|:|.:.
  Rat   441 TGQN-----PA------------DRTVLDNERDYEFPDDSFEPVSTDFHGKEV-IRIRNLTKEYI 487

  Fly   502 FRN----VVKDLFFNVYENEITALVGHKGSGKTTIIMMLCGILQPTTGTVLI--NGYDIVTEAKV 560
            .|:    .:|||..:||:.:|||::||.|:||:|::.:|.|:..||.|.|.|  |....:|:.:.
  Rat   488 QRSKRTEALKDLTLDVYKGQITAILGHSGAGKSTLLNVLSGLCVPTKGWVTIHDNKLSEMTDLES 552

  Fly   561 AKSSLGICPQHSVIFKGMSARDHIYFFSRVKGYNKTEAMMESNIYISKLGLVDSQKWDAMRLSPG 625
            .....|:|||.:|.|..::.|:::..|:::||..:.:  .|....:..|.:.:.|......||.|
  Rat   553 ISKLTGVCPQCNVQFDFLTVRENLRLFAKIKGIQEVD--NEVQRVLLALEMKNIQNTLVQNLSGG 615

  Fly   626 NQRRLSLACALCAGSKVILCDEPSSGLDPIGRHELMRFLQKEKHGRTILMTTQQLEEGEILADRI 690
            .:|:|:...|:....::.|.|||::||||..||.:...|::.|..|.:|.:||.::|.:|||||.
  Rat   616 QKRKLTFGIAILGDPQIFLLDEPTAGLDPFSRHRVWNLLKERKADRVVLFSTQFMDEADILADRK 680

  Fly   691 AIMNDGQILCYGTLGYLKQLPFTSYTLSCQMAPNSKADNLTDLVRLYMTTTTSPVFHGVDVSYKL 755
            ..::.|::.|.|:..:||:.....|.||.|::.....:.:|.||:.::..:.........::|.|
  Rat   681 VFISQGKLRCAGSSLFLKKKWGIGYHLSLQLSETCVHERITSLVKQHIPDSKLSAESEGKLNYIL 745

  Fly   756 PRSQIDRFPEFFQQLEENKKSLNVVSFGVSDSTLDGIYLSL--------DYGQGSSRLRGGA-DP 811
            |..:.::||:.::.| |....|.:.::|||.:||..::|.|        |.|:......||. .|
  Rat   746 PLERTNKFPDLYRDL-ERCPDLGIENYGVSVTTLTEVFLKLEGKSAIDSDIGETEDVQAGGTRGP 809

  Fly   812 GVNDKVEFGVQTDKAIRTKDRANNSLVRYQHQVDPPNETILNTKTPINPIEIWRPIDREKGSCMA 876
            |..|..:|                                         :.:...:.:.||....
  Rat   810 GRLDGEQF-----------------------------------------VSLLNEMSKTKGGMAL 833

  Fly   877 QWQAM-------FIKKKNYTASRALIFILILIIPLFYYIIVLGTAASEKCAHRTD---------- 924
            .||.:       |:|.| |.....:|.||||.|.|.:.:    :|...:..:::|
  Rat   834 WWQQLCAVTRLRFLKLK-YRRKSIVILILILGIGLLHIL----SANVHRLVNQSDYCWELSPHTY 893

  Fly   925 -----KQPVLPLSLDYYSYDDMIILLEVDKQLYKSEGEAYVQLVKEPATVESVDSIFSHLLKAPP 984
                 ::|.:||:          .||.::|                  |.|.:|. |.|.|:..
  Rat   894 FLTPGQRPQMPLT----------NLLIINK------------------TGEKIDD-FLHSLEQQ- 928

  Fly   985 IIRRDIKRKYVCGASFNNASTITAWFNSDAFEHSAPIALNLVYNALGKAVF----EDQDFSILVN 1045
                            |.|..:.|:...:..|.|.       ||  |..:.    ::.:|::..|
  Rat   929 ----------------NIALEVDAFGTRNGTEDSQ-------YN--GAIIVAGGEKNYNFTLACN 968

  Fly  1046 RGDLHDFIWL----NNA------SSMRRRYKRQNDPDYTDYSDYEIQEYDVV-----------VK 1089
            ...|:.|..|    :||      .|:..:..|.:.|:.|.|:.:    |.::           |.
  Rat   969 TKRLNCFPVLVDIVSNALLGLFTPSVHIQTDRSSFPEDTGYTQF----YHLLYMFSWILLMACVP 1029

  Fly  1090 PNSSSTSGQHNKSNPGDDNIITVQMSIIEAASTLYNEKGKRKQLFG-TLIIITAYIALCLSIFSI 1153
            |..|.||....|      |....|:.|...:.:.|        .|| .|..|..|.||.||::..
  Rat  1030 PYISMTSIDDYK------NRAQFQLWISGLSPSAY--------WFGHALFEIPVYSALILSVYIA 1080

  Fly  1154 FVTKERVEHFKMQQEIYGVTLFYFWSTHFVGDFLIYAIYMGALTIAIYHFTIWYQVVVMLLLIGF 1218
            |       :|....|          |.....|..|..:|.|...::         |:.|:.:|.|
  Rat  1081 F-------YFSAPPE----------SMITTRDLFIQILYAGGYAMS---------VIFMMYVISF 1119

  Fly  1219 AC----------------LPFVYLCSLLFSLPNIAFAGIFAILVMTGGMLFSFMYMLTLITDVNF 1267
            .|                :.|:.||.:||..    |...|         |||.:.::.::|.|..
  Rat  1120 ICRKGRKNSGIWSLCFYIVSFISLCLMLFKF----FEDTF---------LFSSIALIPVVTLVGC 1171

  Fly  1268 TTVFAILPMYVGTFGLFKCLAWREYCNREVLPPIEELDCKFGNCNVFCACKPERTWMEVWLL--M 1330
            |.:                    .:.|.| .|.|              :..|||.:..::.|  .
  Rat  1172 TLL--------------------HFQNHE-FPEI--------------SLYPERYYTYLFFLAPF 1201

  Fly  1331 VHCLVWFIFL---WFSNFGYEIGYRFKP-----KLSNRIWHN-----NEKHIRVLDEERRVGLIP 1382
            .|.|: |:|:   ....||.:. .|..|     ..|:|:::|     .|.....|:..|....:.
  Rat  1202 FHFLI-FLFILRCLERKFGMKT-MRMDPVFRISSRSDRVFNNPEEPEGEDEDVSLERVRTANALT 1264

  Fly  1383 KYEHEDYPIIVDQ-VTKNY-----C-----RAKNAVQLVSFAIRPGDTFGLLGAQGAGKTSIFQM 1436
            ..:.::.|:|:.. :.|.|     |     :.|.|.:.:|..:|.|:..||||..||||::..:|
  Rat  1265 SADFQEKPVIIASCLRKEYKGKKKCFVLKGKKKIATRNISLCVRKGEVVGLLGHNGAGKSTSIKM 1329

  Fly  1437 IAGETSMSHGNIYVRGHSLREHRNAAKMEVGFCPQGDNAPKYLTGRQLLRIHCLLHGVPKDHIKA 1501
            |.||...|.|.:.::|:|..:    ....:|:|||.:...:::|.|:.|.|...:.|:.|.....
  Rat  1330 ITGEIKPSAGQVQLKGNSTGD----TPEFLGYCPQENALWQHMTVREHLEIFAAIKGMSKSDAAV 1390

  Fly  1502 VSEQMAIEFNFKDQLDRPIHTYSGGKKRKLNIALAI-DSGSVLCLDDTNGSVDHATQRFIWRKLE 1565
            ...::|.....:|||..|:.|.|.|.||||...|:| .:.||:.||:.:..:|...|:.:|:.::
  Rat  1391 AIARLADALKLQDQLKSPVKTLSEGVKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIQ 1455

  Fly  1566 AV-KRSGRPVLLTTQSMEEANAVCSRVAFLVAGEMMFIGSLQQVRSEVSNTIVIRLRVNPSDGKL 1629
            |. ..:.|..||||..|.||.|||.|||.:|:|::..|||:|.::|:.....::.::|     |.
  Rat  1456 ATFANTERGALLTTHYMAEAEAVCDRVAIMVSGKLRCIGSIQHLKSKFGKEYLLEMKV-----KT 1515

  Fly  1630 KRRFQQLIADMAELFPLATLHEALETCLIYHI-NINVTTLANLFYQMEKIRNEGLLEDYSITQVS 1693
            ..:.:.|..::..|||.|...|...:.::|.: ..:|..|:..|:::|.::....||:||::|.:
  Rat  1516 PTQVEPLNMEIMRLFPQAARQERYSSLMVYKLPREDVQPLSQAFFKLETVKQSFDLEEYSLSQST 1580

  Fly  1694 LDEIYRILNDEED 1706
            |::::..|:.|::
  Rat  1581 LEQVFLELSKEQE 1593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31213	NP_001262752.1	ABC2_membrane_3	32..>295	CDD:289468	59/309 (19%)
		ABC_subfamily_A	491..708	CDD:213230	72/222 (32%)
		drrA	498..796	CDD:130256	92/303 (30%)
		ABC2_membrane_3	<1132..1285	CDD:289468	35/169 (21%)
		CcmA	1391..1672	CDD:224054	89/294 (30%)
		ABC_subfamily_A	1391..1609	CDD:213230	77/230 (33%)
Abca8a	NP_001268753.1	ABC2_membrane_3	27..416	CDD:289468	85/451 (19%)
		DUF4149	267..354	CDD:290390	14/87 (16%)
		ABC_subfamily_A	477..698	CDD:213230	72/222 (32%)
		drrA	493..787	CDD:130256	91/296 (31%)
		ABC2_membrane_3	<1005..1155	CDD:289468	41/197 (21%)
		CcmA	1272..1591	CDD:224054	99/327 (30%)
		ABC_subfamily_A	1279..1500	CDD:213230	76/224 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342184
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850