Protein Alignment CG31213 and Abca12

DIOPT Version :9

• Sequence 1: NP_001262752.1
• Gene: CG31213 / 42382
• FlyBaseID: FBgn0051213
• Length: 1809
• Species: Drosophila melanogaster
• Sequence 2: XP_237242.6
• Gene: Abca12 / 301482
• RGDID: 1304586
• Length: 2595
• Species: Rattus norvegicus
• Alignment Length: 1877
• Identity: 447/1877 - (23%)
• Similarity: 802/1877 - (42%)
• Gaps: 344/1877 - (18%)

  Fly    43 FSIGTKVAKSIFPPDIEMEKSPGPKSVNTSLFVDLYFTPNNGILEQLIT---QLANISE---FKS 101
            ||:|....:.:             |.::....:.|....|..|::||.|   ...|||.   :..
  Rat   875 FSVGLDAVELL-------------KQIDDLDVLRLKLENNIDIIDQLNTLSSLTVNISSCVLYDR 926

  Fly   102 VEVFDTNSELYL---QLMINRNAIG---IAFPS-----EWYDIK--SCPEVLNLTIFMPL----- 148
            ::..||..|:.:   ||..:....|   ...||     ..:|.:  |.|.::..||.|.|
  Rat   927 IQAADTVDEMEMIAKQLYKSNELFGSVIFKLPSNGSSHRGFDSERVSLPPIVRYTIRMSLKTAQT 991

  Fly   149 --SIKRKDF-----------KYFESGFLLLQERISKIFIFFKNAGNGKIPRVLMNHFPYPSYVPN 200
              ||:.|.:           :.:...|:.||:.|.:..|..:...|.:...|.:...|||.::.:
  Rat   992 TRSIRTKIWAPGPHNSPSHNQIYGRAFIYLQDSIERAIIELQTGRNSQEVAVQVQAVPYPCFMKD 1056

  Fly   201 HYAESAKAMTYMTLISFFLPCITIAKYV----------VAEKERHQKAVLTAMGFSNSIHWLAWY 255
            :         ::|.:|:.||.:.:..:|          |.||:......:..||.::..|:.||.
  Rat  1057 N---------FLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWL 1112

  Fly   256 TKSMLLLLLCLLIMISIFSIGLIYEFSSLVCLMTIFLVYIHSLVLFAFFISSFFSRSLSAVVATI 320
            .:|:..||:.:.|:|.|...|.|...::...|...|..|..|::..::.||.||:.:..|.:...
  Rat  1113 IESIGFLLVTIAILIVILKFGNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGS 1177

  Fly   321 LMYFSTALPFLI-VGAENS-SVAAQTAASIGLNSALFYILDSVAVMEMQSVGAQWYTI------D 377
            |:|.....||:: |..|:. |...:...|:...:|..|....:|..|.|.:|.||..:      |
  Rat  1178 LIYVIAFFPFIVLVTVEDELSYVIKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYKSPVQD 1242

  Fly   378 NTASSGYKLSIVGYMLIMISISWIELLICLYIEAVRTGEFEVPQPWSYPFQRRYWCPLRYG-SSV 441
            :|.|.|:...::      ::.|:|...|..|:..|..|.:.:..||.:|....|| ..|:| :.|
  Rat  1243 DTTSFGWLCCLI------LADSFIYFFIAWYVRNVFPGTYGMAAPWYFPVLPSYW-KERFGCAEV 1300

  Fly   442 FHQGAL-LPLAGKNSEGNLPAAHPTRQPIIYLDDRTQENFQRVNISKKIGIEVRSLSKTFGFRNV 505
            .|:.:. |.......:...|:|:.|..     |.....|.:......::|:.:..::|::|.:..
  Rat  1301 KHEKSNGLMFTNIMMQSTNPSANKTSP-----DCAFPSNIEPEPKDLQVGVALHGVTKSYGSKTA 1360

  Fly   506 VKDLFFNVYENEITALVGHKGSGKTTIIMMLCGILQPTTGTVLINGYDIVTEAKVAKSSLGICPQ 570
            |.:|..|.||..||:|:|..|:||||.|.||.|:...|.||:.:.|.||.|:....:.::|:|.|
  Rat  1361 VDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGATAGTIFVYGKDIKTDLNTVRKNMGVCMQ 1425

  Fly   571 HSVIFKGMSARDHIYFFSRVKGYNKTEAMMESNI--YISKLGLVDSQKWDAMRLSPGNQRRLSLA 633
            |.|:|..::.::|:..:..:|..:.|:..:...:  .:...||...:......||.|.:|:||::
  Rat  1426 HDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSIS 1490

  Fly   634 CALCAGSKVILCDEPSSGLDPIGRHELMRFLQKEKHGRTILMTTQQLEEGEILADRIAIMNDGQI 698
            .||..||:|::.||||:|:||..|..:...:.|.|..|||:::|..|:|.|:|:||||.:..|.:
  Rat  1491 IALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGL 1555

  Fly   699 LCYGTLGYLKQLPFTSY--TLSCQMAPNSKADNLTDLVRL-YMTTTTSPVFH-----GVDVSYKL 755
            .|.|:..|||:.....|  ||:.:.:||...:.:.|.|.: .|..:..|..:     |.::.|.|
  Rat  1556 RCCGSPFYLKEAFGDGYHLTLTKKKSPNLDTNAICDTVAVTAMIQSHLPEAYLKEDIGGELVYVL 1620

  Fly   756 P--RSQID-RFPEFFQQLEENKKSLNVVSFGVSDSTLDGIYLSLDYGQGSSRLRGGADPGVNDKV 817
            |  .:::. .:....:.|::....||:..:|:||:|::.::|:|
  Rat  1621 PPFSTKVSGAYLSLLRALDKGMGKLNIGCYGISDTTVEEVFLNL--------------------- 1664

  Fly   818 EFGVQTDKAIRTKD--RANNSLVRYQHQVDPPNETILNTKTPIN-PIEIWRPIDREK-------- 871
                       |||  :..|..:.:..|....|.:...|.||.: .:......||:.
  Rat  1665 -----------TKDSQKCGNMSLEHLTQRKVGNPSANGTSTPDDLSVSSSNFTDRDDKVLTRSER 1718

  Fly   872 ----GSCMAQWQAMFIKKKNYTASRALIFILILIIPLFYYIIVLGTAASEKCAHRTDKQPVLPLS 932
                |..:.:..|:.||:.::|.......|..:::|:.:....:|.......::
  Rat  1719 LDGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVVLPIVFVATAMGLGTLRDSSN----------- 1772

  Fly   933 LDYYSYDDMIILLEVDKQLYKSEGEAYVQLVKEPATVESVDSIFSHLLKAPPI------------ 985
                ||.:::|    ...:|.:..:.......:|:|    :::.|.|...|.|
  Rat  1773 ----SYPELLI----SPSIYGNSEQTAFYANFDPST----NALVSALWNFPGIDNVCLNTSDSQC 1825

  Fly   986 IRRDIKRKY-VCGASFNNASTITAWFN---SDAFEHSAP----IALNLVYNALGKAVFEDQDFSI 1042
            :::|...|: ..|.:.:|....:...|   ...|.:|.|    .:..::||..||
  Rat  1826 LKKDNLGKWNTSGEAIDNFGVCSCSDNVQECPKFNYSPPHRRTYSSQVIYNLTGK---------- 1880

  Fly  1043 LVNRGDLHDFIWLNNASSMRRRY-------KRQNDPDYTDYSDYEIQEYDVVVKPNSSSTS---- 1096
                 .:.:::.......:::||       |..||           ..:||...|.:.:.:
  Rat  1881 -----HMENYLISTANHFVQKRYGGWSFGMKLTND-----------LRFDVTAVPVNRTLAKVWY 1929

  Fly  1097 ---GQHNKS---NPGDDNIITVQMSIIEAAS---TLYNE--KGKRKQLFGTL-----IIITAYIA 1145
               |.|:..   |..::.::.|.||..:||.   .:|:.  .|.:.|...|:     |::...|.
  Rat  1930 DPEGYHSLPAYLNSLNNFLLRVNMSEYDAARHGIIMYSHPYPGVQDQEQATISSLIDILVALSIL 1994

  Fly  1146 LCLSI----FSIFVTKERVEHFKMQQEIYGVTLFYFWSTHFVGDFLIY----AIYMGALTIAIYH 1202
            :..|:    |..::.:|.....|..|.|.|:.:..:|.|:|:.|.:.|    |..:|  .|||:.
  Rat  1995 MGYSVTTASFVTYIVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIG--VIAIFK 2057

  Fly  1203 FTIWYQ------VVVMLLLIGFACLPFVYLCSLLFSLPNIAFA---------GIFAILVMTGGML 1252
            ...:|.      |.::|||.|:|...::||.:.||....:||.         ||.:|:.:
  Rat  2058 LPAFYSGNNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSL----- 2117

  Fly  1253 FSFMYMLT----------LITDVNFTTVFAILPMYVGTFGLFKCLAWREYCNREVLP-------- 1299
             |.:|.|:          ||:: ....:|.|.|.:...:||.:...     .:.||.
  Rat  2118 -SVVYFLSKEKPNDPTLELISE-TLKRIFLIFPQFCFGYGLIELSQ-----QQAVLDFLKAYGVD 2175

  Fly  1300 -PIE--ELDCKFGNCNVFCACKPERTWMEVWLLMVHCLVWFI---FLWFSNFGYEIGYRFKPKLS 1358
             |.|  |:| |.|  .:|.|...:.|...:..|:::  .|.|   .|:|..|           .|
  Rat  2176 YPSETFEMD-KLG--AMFVALVSQGTMFFLLRLLIN--EWLIKKLRLFFRKF-----------TS 2224

  Fly  1359 NRIWHNNEKHIRVLDEERRVGLIPKYEHEDYPII-VDQVTKNYCRAKN---AVQLVSFAIRPGDT 1419
            :.:....::...|..|..||    :....::.:: :.::||.|.....   ||..:|..|..|:.
  Rat  2225 SPVMETVDEDEDVHTERLRV----ESGAAEFDLVQLHRLTKTYQLIHKKIIAVNNISLGIPAGEC 2285

  Fly  1420 FGLLGAQGAGKTSIFQMIAGETSMSHGNIYVRGHS-LREHRNAAKMEVGFCPQGDNAPKYLTGRQ 1483
            |||||..|||||:||:|:.|:...|.|||.:|..| ...|.::....||:|||.|.....:|..:
  Rat  2286 FGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKSGSLGHVDSHSSLVGYCPQEDALDDLVTVEE 2350

  Fly  1484 LLRIHCLLHGVPKDHIKAVSEQMAIEFNFKDQLDRPIHTYSGGKKRKLNIALA-IDSGSVLCLDD 1547
            .|..:..:||:|:..||....::....:.....||.....|.|.||||:.||| |...|:|.||:
  Rat  2351 HLYFYARVHGIPEKDIKETVHKLLRRLHLMAYKDRSTSMCSYGTKRKLSTALALIGKPSILLLDE 2415

  Fly  1548 TNGSVDHATQRFIWRKLEAVKRSGRPVLLTTQSMEEANAVCSRVAFLVAGEMMFIGSLQQVRSEV 1612
            .:..:|..::|.:||.:....::...|:||:.||||..|:|:|:|.:|.|....|||||.::|..
  Rat  2416 PSSGMDPKSKRHLWRIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGRFQCIGSLQHIKSRF 2480

  Fly  1613 SN--TIVIRLRVNPSDGKLKRRFQQLIADMAELFPLATLHEALETCLIYHININVTTLANLFYQM 1675
            ..  |:.:.|:.|....:...:|.||      .||...|.:...:.|.||:.:....:||:|..:
  Rat  2481 GRGFTVKVHLKNNKVSMENLTKFMQL------HFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLL 2539

  Fly  1676 EKIRNEGLLEDYSITQVSLDEIY-RILNDEEDPNLVDLDSTHNSEVLEDIRDTTRDT 1731
            |..:....:.::.::|.:|:|:: ....|::....|| .|:..|.:..|.::...|:
  Rat  2540 ETNKTALNITNFLVSQTTLEEVFINFAKDQKSYENVD-TSSQGSTISVDSQEDQLDS 2595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31213	NP_001262752.1	ABC2_membrane_3	32..>295	CDD:289468	64/298 (21%)
		ABC_subfamily_A	491..708	CDD:213230	75/218 (34%)
		drrA	498..796	CDD:130256	98/310 (32%)
		ABC2_membrane_3	<1132..1285	CDD:289468	47/190 (25%)
		CcmA	1391..1672	CDD:224054	95/288 (33%)
		ABC_subfamily_A	1391..1609	CDD:213230	80/223 (36%)
Abca12	XP_237242.6	ABC2_membrane_3	<1006..1267	CDD:289468	63/275 (23%)
		NosY	<1108..1269	CDD:224196	43/166 (26%)
		ZnuC	1346..1570	CDD:224046	77/223 (35%)
		ABC_subfamily_A	1350..1565	CDD:213230	75/214 (35%)
		ABC2_membrane_3	<1913..2174	CDD:289468	62/274 (23%)
		CcmA	2253..2567	CDD:224054	100/319 (31%)
		ABC_subfamily_A	2254..2477	CDD:213230	80/222 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342224
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950