Protein Alignment CG31213 and Abca7

DIOPT Version :10

• Sequence 1: NP_732473.2
• Gene: CG31213 / 42382
• FlyBaseID: FBgn0051213
• Length: 1809
• Species: Drosophila melanogaster
• Sequence 2: NP_997481.2
• Gene: Abca7 / 299609
• RGDID: 1303134
• Length: 2170
• Species: Rattus norvegicus
• Alignment Length: 2065
• Identity: 494/2065 - (23%)
• Similarity: 820/2065 - (39%)
• Gaps: 483/2065 - (23%)

  Fly    14 LLWKDIKLQL---------TNWV------------ELVMIIFLSALMPI-------FFSIGTKVA 50
            |||:.:|..:         ||:.            ||.::..|..|..:       |.:..|.||
  Rat   279 LLWRRLKPLILGKILFAPDTNFTRKLMAQVNQTFEELALLRDLHELWGVLGPQIFNFMNDSTNVA 343

  Fly    51 KSIFPPDIE----MEKSP-GPKSVNTSLFVDLYFTPNN------------GILEQLITQLANISE 98
            ......|:|    .:::| |.|.:..   :..:..|:.            |.|.:::.|:.....
  Rat   344 MLQKLLDVEGTGWQQQTPKGQKQLEA---IRDFLDPSRGRYNWQEAHADMGRLAEILGQILECVS 405

  Fly    99 FKSVEVFDTNSELY---LQLMINRNA-IGIAFPSEWYDIKSC---------PEVLNLTIFMPL-- 148
            ...:|...:...|.   |:|:..|.. .||.|.|..:.:.|.         |..|.:.|.|.:
  Rat   406 LDKLEAVPSEEALVSRALELLGERRLWAGIVFLSPEHPLDSSEPPSPTTTGPGHLRVKIRMDIDD 470

  Fly   149 -----SIKRK------------DFKYFESGFLLLQERISKIFIFFKNAGNGKIPR--VLMNHFPY 194
                 .|:.|            |.:|...||:.||:.:.:..:   ...:|:..|  :.:...|:
  Rat   471 VTRTNKIRDKFWDPGPSADPLMDLRYVWGGFVYLQDLLEQAAV---RVLSGRDSRAGLYLQQMPH 532

  Fly   195 PSYVPNHYAE--SAKAMTYMTLISFFLPCITIAKYVVAEKERHQKAVLTAMGFSNSIHWLAWYTK 257
            |.||.:.:..  |.....::||...:...:|: |.||.|||...:..:.|||.|.::.||.|:..
  Rat   533 PCYVDDVFLRVLSRSLPLFLTLAWIYSVALTV-KAVVREKETRLRETMRAMGLSRAVLWLGWFLS 596

  Fly   258 SMLLLLLCLLIMISIFSIGLIYEFSSLVCLMTIFLVYIHSLVLFAFFISSFFSRSLSAVVATILM 322
            .:...|:...:::.:..:|.|..:|..|.:......:..:.|..:|.:|:||||:..|.....|.
  Rat   597 CLGPFLVSAALLVLVLKLGNILPYSHPVVVFLFLAAFAVATVAQSFLLSAFFSRANLAAACGGLA 661

  Fly   323 YFSTALPFLIVGA--ENSSVAAQTAASIGLNSALFYILDSVAVMEMQSVGAQWYTI-DNTASSGY 384
            ||:..||:::..|  |...:....|.|:....|..:..:|:|::|.|..||||:.: ...|...:
  Rat   662 YFALYLPYVLCVAWRERLPLGGLLAVSLLSPVAFGFGCESLALLEEQGDGAQWHNLGTGPAEDVF 726

  Fly   385 KLSIVGYMLIMISISWIELLICLYIEAVRTGEFEVPQPWSYPFQRRYWC-PLRYGSSVFHQGALL 448
            .|:.|...|::.::  |..|...|:|||..|::.:|:||::||:|.||| |....|||.......
  Rat   727 SLAQVSAFLLLDAV--IYGLALWYLEAVCPGQYGIPEPWNFPFRRSYWCGPGPPKSSVLAPAPQD 789

  Fly   449 P--LAGKNSEGNLPAAHPTRQPIIYLDDRTQENFQRVNISKKIGIEVRSLSKTF--GFRNVVKDL 509
            |  |..:...|.:|                             |:.:|.|.|.|  ..:..::.|
  Rat   790 PKVLVEEPPPGLVP-----------------------------GVSIRGLKKHFRGSPQPALRGL 825

  Fly   510 FFNVYENEITALVGHKGSGKTTIIMMLCGILQPTTGTVLINGYDIVTEAKVAKSSLGICPQHSVI 574
            ..:.||..|||.:||.|:||||.:.:|.|:..|::|:..|.|:|:.|.....:..||||||::|:
  Rat   826 NLDFYEGHITAFLGHNGAGKTTTLSILSGLFPPSSGSASILGHDVQTNMAAIRPHLGICPQYNVL 890

  Fly   575 FKGMSARDHIYFFSRVKGYNKTEAMMESNIYISKLGLVDSQKWDAMRLSPGNQRRLSLACALCAG 639
            |..::..:|::|:.|:||.:......|....|..:||:..:......||.|.||:||:|.|...|
  Rat   891 FDMLTVEEHVWFYGRLKGVSAAAIDSEQEHLIRDVGLIPKRDTQTRHLSGGMQRKLSVAIAFVGG 955

  Fly   640 SKVILCDEPSSGLDPIGRHELMRFLQKEKHGRTILMTTQQLEEGEILADRIAIMNDGQILCYGT- 703
            |:|::.|||::|:||..|..:...|.|.:.|||::::|..|:|.|:|.||:|::..|.:.|.|:
  Rat   956 SRVVIMDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAMVASGSLCCCGSP 1020

  Fly   704 --------LGYLKQLPFTSYTL-----------------------------------SCQMAPNS 725
                    .||...|..:|.:|                                   ....||..
  Rat  1021 LFLRRHLGCGYYLTLVKSSQSLVTHDLKGDTEDPRREKKSGSEGKTADTVLTRDGPHRSSQAPAP 1085

  Fly   726 KADNLTDLVRLYMTTTTSPVFHGVDVSYKLPRSQI----------DRFPEFFQQLEENKKSLNVV 780
            .|..:|....|.:......| .|..:..:||...:          ..|...||:|::..:.|.:.
  Rat  1086 DAVPVTPSAALILELVQRHV-PGAQLVEELPHELVLALPYAGALDGSFATVFQELDQQLERLGLT 1149

  Fly   781 SFGVSDSTLDGIYLSL---DYGQGSSRLRGGADPGVNDKVEFGVQTDKAIRTKDRANNSLVRYQH 842
            .:|:||:.|:.|:|.:   .:..|.     |.||                    |....|:....
  Rat  1150 GYGISDTNLEEIFLKVVEEAHAHGE-----GGDP--------------------RQQQHLLTATP 1189

  Fly   843 QVDP-PNETILN----TKTPINPIEIWRPIDREKGSC--MAQWQAMFIKKKNYTA---------- 890
            |... |..::|.    .|..::|       ...|||.  .||.|...:..:...|
  Rat  1190 QPHTGPEASVLENGELAKLVLDP-------QAPKGSAPTTAQVQGWTLTCQQLRALLHKRFLLAR 1247

  Fly   891 -SRALIFILILI------IPLFYYIIV--LGTAASEKCAHRTDKQPVLPLSLDYYSYDDMIILLE 946
             ||..:|..|::      :.||:.:||  .|            :.|  ||.|....|...:....
  Rat  1248 RSRRGLFAQIVLPALFVGLALFFTLIVPPFG------------QYP--PLQLSPAMYGPQVSFFS 1298

  Fly   947 VD--------KQLYKSEGEAYVQLVKEPAT--VESVDSIFSHLL-------KAPPIIRRDIKRKY 994
            .|        |.|....|||.:|   :|:.  ..|..|..:|.|       :.||.:
  Rat  1299 EDAPADPNRMKLLEALLGEAGLQ---DPSVQGKGSRGSECTHSLACYFTVPEVPPDV-------- 1352

  Fly   995 VCGASFNNASTITAWFNSDAFEHSAPIALNL-----------------------VYNALGKAVFE 1036
               ||...:...|....|.|.:.|.|.|..|                       |.|..|:.|
  Rat  1353 ---ASILASGNWTPDSPSPACQCSQPGARRLLPDCPAGAGGPPPPQAMAGFGEVVQNLTGRNV-- 1412

  Fly  1037 DQDFSI-----LVNRGDLHDFIWLNNASSMRRRY----KRQNDPDYTDYSDY--EIQEYDVVVKP 1090
             .||.:     ||.|| |....|::..     ||    ....|||.....:.  .:.|...::.|
  Rat  1413 -SDFLVKTYPSLVRRG-LKTKKWVDEV-----RYGGFSLGGRDPDLPSGREVVRTVAEMRALLSP 1470

  Fly  1091 NSSST---------------------------SGQH------NKSNPGDDNIITVQMSIIEAAS- 1121
            ...:|                           .|.|      |::|.|.........|:..|.|
  Rat  1471 QPGNTLDRILNNLTQWALGLDARNSLKIWFNNKGWHAMVAFVNRANNGLLRAFLPSGSVRHAHSI 1535

  Fly  1122 -TLYNEKGKRKQLFGTLIIITAYIALCLSI------------FSIFVTKERVEHFKMQQEIYGVT 1173
             ||.:.....|:......:|.:.:.:.:||            |::.:.:||:...|..|.:.|:.
  Rat  1536 TTLNHPLNLTKEQLSEATLIASSVDVLVSICVVFAMSFVPASFTLVLIEERITRAKHLQLVSGLP 1600

  Fly  1174 LFYFWSTHFVGDFLIYAIYMGALTIAIYHFTIWYQ-----------VVVMLLLIGFACLPFVYLC 1227
            ...:|..:|:.|...|.:   |:.|.:..|..:.|           ::::|||.|::..|.:|..
  Rat  1601 QTLYWLGNFLWDMCNYLV---AVCIVVLIFLAFQQKAYVAPENLPALLLLLLLYGWSITPLMYPA 1662

  Fly  1228 SLLFSLPNIAFAGIFAILVMTGGMLFSFMYMLTLITDVN-------FTTVFAILPMYVGTFGLFK 1285
            |..||:|:.|:..:..|.:..|.......::|.|::|.|       ...||.|.|.:....||..
  Rat  1663 SFFFSVPSTAYVVLTCINLFIGINSSMATFVLELLSDQNLQEVSRILKQVFLIFPHFCLGRGLID 1727

  Fly  1286 CLAWREYCNREVLPPIEEL-DCKFGN--------CNVFCACKPERTWMEVWLLMVHCLVWFIFLW 1341
            .:.     |:.:....|.| |.:|.:        .|:.........::.:.||:.|
  Rat  1728 MVR-----NQAMADAFERLGDKQFQSPLRWDIIGKNLLAMVAQGPLFLLITLLLQH--------- 1778

  Fly  1342 FSNFGYEIGYRFKPKLSNR----IWHNNEKHIRVLDEERRVGLIPKYEHEDYPIIVDQVTKNYCR 1402
                    ..|..|:..:|    :...:|..:|  :.||    :.|...:...:::..:||.|..
  Rat  1779 --------RNRLLPQPKSRLPPPLGEEDEDVVR--ERER----VTKGATQGDVLVLRDLTKVYRG 1829

  Fly  1403 AKN-AVQLVSFAIRPGDTFGLLGAQGAGKTSIFQMIAGETSMSHGNIYVRGHSLREHRNAAKMEV 1466
            .:: ||..:...|.||:.|||||..||||||.|:|:.|:|..|.|...:.||::.:..:||...:
  Rat  1830 QRSPAVDHLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLPSSGEAVLAGHNVAQEPSAAHRSM 1894

  Fly  1467 GFCPQGDNAPKYLTGRQLLRIHCLLHGVPKDHIKAVSEQMAIEFNFKDQLDRPIHTYSGGKKRKL 1531
            |:|||.|.....||||:.|.:...|.|||:..:...:....:........|||..|||||.||||
  Rat  1895 GYCPQSDAIFDLLTGREHLELFARLRGVPEAQVAQTALSGLVRLGLPSYADRPAGTYSGGNKRKL 1959

  Fly  1532 NIALA-IDSGSVLCLDDTNGSVDHATQRFIWRKLEAVKRSGRPVLLTTQSMEEANAVCSRVAFLV 1595
            ..||| :...:|:.||:....:|.:.:||:|..|.:|.|.||.|:||:.||||..|:|:|:|.:|
  Rat  1960 ATALALVGDPAVVFLDEPTTGMDPSARRFLWNNLLSVVREGRSVVLTSHSMEECEALCTRLAIMV 2024

  Fly  1596 AGEMMFIGSLQQVRSEVSNTIVIRLRVNPSDGKLKRRFQQLIADMAELFPLATLHEALETCLIYH 1660
            .|....:||.|.::|.......:.|||.|...      :..||.:...||.|.|.|...:.|.:.
  Rat  2025 NGRFRCLGSAQHLKSRFGAGHTLTLRVPPDQP------EPAIAFIVTTFPDAELREVHGSRLRFQ 2083

  Fly  1661 INI-NVTTLANLFYQMEKIRNEGLLEDYSITQVSLDEIYRILN----DEEDPNLVDLDSTHNSEV 1720
            :.. ....||.:|.::........:||:|::|.:|:|::...:    :||:.:
  Rat  2084 LPPGGGCKLARVFRELAAQGKAHGVEDFSVSQTTLEEVFLYFSKDQGEEEEGS------------ 2136

  Fly  1721 LEDIRDTTRDTTRGTTRDTNLVSDEGIQKEKVKRKKVEEEDRDRQESTET 1770
                         |...:|..||..|:|..|...:.:|:     ..|.||
  Rat  2137 -------------GQETETREVSTPGLQHPKRVSRFLED-----PSSVET 2168

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31213	NP_732473.2	rim_protein	<118..1698	CDD:130324	454/1835 (25%)
Abca7	NP_997481.2	rim_protein	1..2127	CDD:130324	481/1992 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1044..1086		2/41 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2129..2170		13/70 (19%)