DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31213 and ABCA12

DIOPT Version :10

Sequence 1:NP_732473.2 Gene:CG31213 / 42382 FlyBaseID:FBgn0051213 Length:1809 Species:Drosophila melanogaster
Sequence 2:XP_011509253.1 Gene:ABCA12 / 26154 HGNCID:14637 Length:2598 Species:Homo sapiens


Alignment Length:1899 Identity:454/1899 - (23%)
Similarity:800/1899 - (42%) Gaps:398/1899 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 FSIG---TKVAKSIFPPDIEMEKSPGP----KSVNT--SLFVDLYFTPNNGILEQLITQLANISE 98
            ||:|   .::.|.|...||...|....    ..:||  ||.|::    ::.:|...|.....|.|
Human   878 FSVGLDAVELLKQIDELDILRLKLENNIDIIDQLNTLSSLTVNI----SSCVLYDRIQAAKTIDE 938

  Fly    99 --------FKSVEVFDTNSELYLQLMINRNAIGIAFPSEW---YDIKS--CPEVLNLTIFMPL-- 148
                    :||.|:|   ..:..:|..||:         |   ||..:  .|.|:..||.|.|  
Human   939 MEREAKRLYKSNELF---GSVIFKLPSNRS---------WHRGYDSGNVFLPPVIKYTIRMSLKT 991

  Fly   149 -----SIKRKDF-----------KYFESGFLLLQERISKIFIFFKNAGNGKIPRVLMNHFPYPSY 197
                 |::.|.:           :.:...|:.||:.|.:..|..:...|.:...|.:...|||.:
Human   992 AQTTRSLRTKIWAPGPHNSPSHNQIYGRAFIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPCF 1056

  Fly   198 VPNHYAESAKAMTYMTLISFFLPCITIAKYV----------VAEKERHQKAVLTAMGFSNSIHWL 252
            :.::         ::|.:|:.||.:.:..:|          |.||:......:..||.::..|:.
Human  1057 MKDN---------FLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFF 1112

  Fly   253 AWYTKSMLLLLLCLLIMISIFSIGLIYEFSSLVCLMTIFLVYIHSLVLFAFFISSFFSRSLSAVV 317
            ||..:|:..||:.::|:|.|...|.|...::...|...|..|..|::..::.||.||:.:..|.:
Human  1113 AWLIESVGFLLVTIVILIIILKFGNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAAL 1177

  Fly   318 ATILMYFSTALPFLI-VGAENS-SVAAQTAASIGLNSALFYILDSVAVMEMQSVGAQW---YTI- 376
            ...|:|.....||:: |..||. |...:...|:...:|..|....:|..|.|.:|.||   ||. 
Human  1178 IGSLIYIIAFFPFIVLVTVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSP 1242

  Fly   377 --DNTASSGYKLSIVGYMLIMISISWIELLICLYIEAVRTGEFEVPQPWSYPFQRRYWCPLRYGS 439
              |:|.|.|:...::      ::.|:|..||..|:..|..|.:.:..||.:|....|| ..|:|.
Human  1243 VQDDTTSFGWLCCLI------LADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYW-KERFGC 1300

  Fly   440 SVFHQGALLPLAGKNSEGNL----------PAAHPTRQPIIYLDDRTQENFQRVNISKKIGIEVR 494
            :        .:..:.|.|.:          |:|..|....::     ..|.:.......:|:.:.
Human  1301 A--------EVKPEKSNGLMFTNIMMQNTNPSASKTSPEYMF-----SSNIEPEPKDLTVGVALH 1352

  Fly   495 SLSKTFGFRNVVKDLFFNVYENEITALVGHKGSGKTTIIMMLCGILQPTTGTVLINGYDIVTEAK 559
            .::|.:|.:..|.:|..|.||..||:|:|..|:||||.|.||.|:...:.||:.:.|.||.|:..
Human  1353 GVTKIYGSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLH 1417

  Fly   560 VAKSSLGICPQHSVIFKGMSARDHIYFFSRVKGYNKTEAMMESNI--YISKLGLVDSQKWDAMRL 622
            ..:.::|:|.||.|:|..::.::|:..:..:|..:.|:..:...:  .:...||...:......|
Human  1418 TVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTL 1482

  Fly   623 SPGNQRRLSLACALCAGSKVILCDEPSSGLDPIGRHELMRFLQKEKHGRTILMTTQQLEEGEILA 687
            |.|.:|:||::.||..||:|::.||||:|:||..|..:...:.|.|..|||:::|..|:|.|:|:
Human  1483 SGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLS 1547

  Fly   688 DRIAIMNDGQILCYGTLGYLKQLPFTSY--TLSCQMAPNSKADNLTDLVRLYMTTTTSPVFH--- 747
            ||||.:..|.:.|.|:..|||:.....|  ||:.:.:||..|:.:.|.    |..|.....|   
Human  1548 DRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDT----MAVTAMIQSHLPE 1608

  Fly   748 -------GVDVSYKLP--RSQID-RFPEFFQQLEENKKSLNVVSFGVSDSTLDGIYLSLDYGQGS 802
                   |.::.|.||  .:::. .:....:.|:.....||:..:|:||:|::.::|:|      
Human  1609 AYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNL------ 1667

  Fly   803 SRLRGGADPGVNDKVEFGVQTDKAIRTKDRANNSLVRYQH----QVDPPNETILNTKTPINPIEI 863
                                      ||:...||.:..:|    ::...|...::|...:: :..
Human  1668 --------------------------TKESQKNSAMSLEHLTQKKIGNSNANGISTPDDLS-VSS 1705

  Fly   864 WRPIDREK------------GSCMAQWQAMFIKKKNYTASRALIFILILIIPLFYYIIVLGTAAS 916
            ....||:.            |..:.:..|:.||:.::|.......|..:|:|:.:....:|....
Human  1706 SNFTDRDDKILTRGERLDGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVTTAMGLGTL 1770

  Fly   917 EKCAHRTDKQPVLPLSLDYYSYDDMIILLEVDKQLYKSEGEAYVQLVKEPATVESVDSIFSHLLK 981
            ...::               ||.:    :::...||.:..:........|:|    :::.|.:..
Human  1771 RNSSN---------------SYPE----IQISPSLYGTSEQTAFYANYHPST----EALVSAMWD 1812

  Fly   982 APPI------------IRRDIKRKY-----------VCGASFNNASTITAWFNSDAFEHSAP--- 1020
            .|.|            :.:|...|:           ||..|.|..       ....|.:|.|   
Human  1813 FPGIDNMCLNTSDLQCLNKDSLEKWNTSGEPITNFGVCSCSENVQ-------ECPKFNYSPPHRR 1870

  Fly  1021 -IALNLVYNALGKAVFEDQDFSILVNRGDLHDFIWLNNASSMRRRYKRQND--PDYTDYSDYEIQ 1082
             .:..::||..|:.|   :::.|    ...::|:        ::||...:.  |...|.      
Human  1871 TYSSQVIYNLTGQRV---ENYLI----STANEFV--------QKRYGGWSFGLPLTKDL------ 1914

  Fly  1083 EYDVVVKPNSSSTS-------GQHNKS---NPGDDNIITVQMSIIEAAS---TLYNE--KGKRKQ 1132
            .:|:...|.:.:.:       |.|:..   |..::.::.|.||..:||.   .:|:.  .|.:.|
Human  1915 RFDITGVPANRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSKYDAARHGIIMYSHPYPGVQDQ 1979

  Fly  1133 LFGTL-----IIITAYIALCLSI----FSIFVTKERVEHFKMQQEIYGVTLFYFWSTHFVGDFLI 1188
            ...|:     |::...|.:..|:    |..:|.:|.....|..|.|.|:.:..:|.|:|:.|.:.
Human  1980 EQATISSLIDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVF 2044

  Fly  1189 Y----AIYMGALTIAIYHFTIWYQ------VVVMLLLIGFACLPFVYLCSLLFSLPNIAFA---- 1239
            |    |..:|  .|||:....:|.      |.::|||.|:|...::||.:.||....:||.    
Human  2045 YLVPVAFSIG--IIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVC 2107

  Fly  1240 -----GIFAILVMTGGMLFSFMYMLT----------LITDVNFTTVFAILPMYVGTFGLFKCLAW 1289
                 ||.:|:.:      |.:|.|:          ||:: ....:|.|.|.:...:||.:....
Human  2108 VNLFFGINSIVSL------SVVYFLSKEKPNDPTLELISE-TLKRIFLIFPQFCFGYGLIELSQQ 2165

  Fly  1290 R-----------EYCNREVLPPIEELDCKFGNCNVFCACKPERT-WMEVWLLMVHCLVWFIFLWF 1342
            :           ||.|...     |:: |.|  .:|.|...:.| :..:.||:...|:..:.|:|
Human  2166 QSVLDFLKAYGVEYPNETF-----EMN-KLG--AMFVALVSQGTMFFSLRLLINESLIKKLRLFF 2222

  Fly  1343 SNFGYEIGYRFKPKLSNRIWHNNEKHIR-VLDEERRVGLIPKYEHEDYPIIVDQVTKNYCRAKN- 1405
            ..|                   |..|:| .:||:..| ...:...|......|.| :.||..|. 
Human  2223 RKF-------------------NSSHVRETIDEDEDV-RAERLRVESGAAEFDLV-QLYCLTKTY 2266

  Fly  1406 --------AVQLVSFAIRPGDTFGLLGAQGAGKTSIFQMIAGETSMSHGNIYVR------GHSLR 1456
                    ||..:|..|..|:.|||||..|||||:||:|:.|:...|.|||.:|      || :.
Human  2267 QLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGH-VD 2330

  Fly  1457 EHRNAAKMEVGFCPQGDNAPKYLTGRQLLRIHCLLHGVPKDHIKAVSEQMAIEFNFKDQLDRPIH 1521
            .|.:.    ||:|||.|.....:|..:.|..:..:||:|:..||....::....:.....||...
Human  2331 SHSSL----VGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATS 2391

  Fly  1522 TYSGGKKRKLNIALA-IDSGSVLCLDDTNGSVDHATQRFIWRKLEAVKRSGRPVLLTTQSMEEAN 1585
            ..|.|.||||:.||| |...|:|.||:.:..:|..::|.:|:.:....::...|:||:.||||..
Human  2392 MCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEECE 2456

  Fly  1586 AVCSRVAFLVAGEMMFIGSLQQVRSEVSN--TIVIRLRVNPSDGKLKRRFQQLIADMAELFPLAT 1648
            |:|:|:|.:|.|:...|||||.::|....  |:.:.|:.|....:...:|.||      .||...
Human  2457 ALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQL------HFPKTY 2515

  Fly  1649 LHEALETCLIYHININVTTLANLFYQMEKIRNEGLLEDYSITQVSLDEIY-RILNDEEDPNLVDL 1712
            |.:...:.|.||:.:....:||:|..:|..:....:.::.::|.:|:|:: ....|::.....| 
Human  2516 LKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSYETAD- 2579

  Fly  1713 DSTHNSEVLEDIRD 1726
            .|:..|.:..|.:|
Human  2580 TSSQGSTISVDSQD 2593

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31213NP_732473.2 rim_protein <118..1698 CDD:130324 426/1776 (24%)
ABCA12XP_011509253.1 rim_protein 7..>86 CDD:130324
rim_protein 752..2579 CDD:130324 449/1882 (24%)
Blue background indicates that the domain is not in the aligned region.

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