DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31213 and ABCA5

DIOPT Version :9

Sequence 1:NP_001262752.1 Gene:CG31213 / 42382 FlyBaseID:FBgn0051213 Length:1809 Species:Drosophila melanogaster
Sequence 2:NP_061142.2 Gene:ABCA5 / 23461 HGNCID:35 Length:1642 Species:Homo sapiens


Alignment Length:1842 Identity:420/1842 - (22%)
Similarity:792/1842 - (42%) Gaps:347/1842 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 RNLTYCQKYRLLLWKDIKLQLTNWVELVMIIFLSALMPIFFSIGTKVAKSIFP-------PDIEM 60
            |.:...::.|.||.|:..::.......|..|    |.|:||.....:...:.|       |:||:
Human     6 REVGVWRQTRTLLLKNYLIKCRTKKSSVQEI----LFPLFFLFWLILISMMHPNKKYEEVPNIEL 66

  Fly    61 EKSPGPKSVNTSLFVDLYFTPNNGILEQLITQLA--NISEFKSVEVFDTNSELYLQLMINR--NA 121
              :|..|...::|.  |.:||...|...::.:::  ::.:....|.: ||.:..|...:::  |.
Human    67 --NPMDKFTLSNLI--LGYTPVTNITSSIMQKVSTDHLPDVIITEEY-TNEKEMLTSSLSKPSNF 126

  Fly   122 IGIAF-PSEWYDIKSCPEVLNL-TIFMP----LSIKRKDFKYFESGFLLLQERISKIFIFFKNAG 180
            :|:.| .|..|:::..|:::.: :|:|.    .|...:..:|:.|||.:||..|....|..|...
Human   127 VGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASIDAAIIQLKTNV 191

  Fly   181 N-------------GKIPRVLMNHFPYPSYVPNHYAESAKAMTYMTLISFFLPC-ITIAKYVVAE 231
            :             |:...|.::.||             :.:..:.|:..|.|. ..:|.::|||
Human   192 SLWKELESTKAVIMGETAVVEIDTFP-------------RGVILIYLVIAFSPFGYFLAIHIVAE 243

  Fly   232 KERHQKAVLTAMGFSNSIHWLAWYTKSMLLLLLCLLIMISIFSIGLIYEFSSLVCLMTIFLVYIH 296
            ||:..|..|..||..::..||:|......|:.|..|:|..|.:..|::..||.:.:..:|.:|..
Human   244 KEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGL 308

  Fly   297 SLVLFAFFISSFFSRSLSAVVATILMYFSTALPFLIVGAENSSVAAQTAASIGLNSAL---FYIL 358
            |.|.||..::..|.:|..   ..|:.:|.| :.|..:|.....:.:...:.:.|.|..   .:::
Human   309 SSVFFALMLTPLFKKSKH---VGIVEFFVT-VAFGFIGLMIILIESFPKSLVWLFSPFCHCTFVI 369

  Fly   359 DSVAVMEMQ--SVGAQWYTIDNTASSGYKLSIVGYMLIMISISWIELLICLYIEAVRTGEFEVPQ 421
            ....||.::  :.||   :..|..:..|.|.|...||.:.||.::  |:.:|::.|..|||.:.:
Human   370 GIAQVMHLEDFNEGA---SFSNLTAGPYPLIITIIMLTLNSIFYV--LLAVYLDQVIPGEFGLRR 429

  Fly   422 PWSYPFQRRYWCPLRYGSSVFHQGALLPLAGKNSEGNLPAAHPTRQPIIYLDDRTQENFQRVNIS 486
            ...|..:..||...:.......:|        |..||:..:               |..:.|: |
Human   430 SSLYFLKPSYWSKSKRNYEELSEG--------NVNGNISFS---------------EIIEPVS-S 470

  Fly   487 KKIG---IEVRSLSKTFGFR--NV--VKDLFFNVYENEITALVGHKGSGKTTIIMMLCGILQPTT 544
            :.:|   |.:..:.||:..:  ||  :::|.|::||.:||||:||.|:||:|::.:|||:..|:.
Human   471 EFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSD 535

  Fly   545 GTVLINGYDI--VTEAKVAKSSLGICPQHSVIFKGMSARDHIYFFSRVKGYNKTEAMMESNIYIS 607
            |...|.|:.:  :.|...|:..:|||||..:.|..::..:::...:.:||......:.|....:.
Human   536 GFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLL 600

  Fly   608 KLGLVDSQKWDAMRLSPGNQRRLSLACALCAGSKVILCDEPSSGLDPIGRHELMRFLQKEKHGRT 672
            .|.:...:...|.:||.|.:|:|||..|:....|::|.|||::|:||..||.:...|:..|..|.
Human   601 DLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRV 665

  Fly   673 ILMTTQQLEEGEILADRIAIMNDGQILCYGTLGYLKQLPFTSYTLSCQMAPNSKADNLTDLVRLY 737
            .:.:|..::|.:|||||.|:::.|.:.|.|:..:||......|.||..:......::|:.||:.:
Human   666 TVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLVKQH 730

  Fly   738 MTTTTSPVFHGVDVSYKLPRSQIDRFPEFFQQLEENKKSLNVVSFGVSDSTLDGIYLSLDYGQGS 802
            :...|....:...:.|.||...:|:|...|..|:.: .:|.|:|:|||.:||:.::|.|:.    
Human   731 IPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSH-SNLGVISYGVSMTTLEDVFLKLEV---- 790

  Fly   803 SRLRGGADPGVNDKVEFGVQTDKAI------RTKDRANNSLVRYQHQVDPPNETILNTKTP-INP 860
                    ....|:.::.|.|.:.:      ::.|....||:           .:..||.. ::.
Human   791 --------EAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLL-----------ILSETKAALVST 836

  Fly   861 IEIWRPIDREKGSCMAQWQAMFIKKKNYTASRALIFILILI-IPLFYYIIVLGTAASEKCAHRTD 924
            :.:|    :::...:|::....:|:::.:....|:.:||.. :.:|.:::           |.:.
Human   837 MSLW----KQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLV-----------HHSF 886

  Fly   925 KQPVLPLSLDYYSYDDMIILLEVDKQLYKSEGEAYVQLVKEPATVESVDSIFSHLLKAPPIIRRD 989
            |..|:|:.|    ..|:..|...||. :|.:....:|        .|.||..|.|:         
Human   887 KNAVVPIKL----VPDLYFLKPGDKP-HKYKTSLLLQ--------NSADSDISDLI--------- 929

  Fly   990 IKRKYVCGASFNNASTITAWFNSDAFEHSAP--IALNLVYNALGKAVFEDQDFSILVNRGDLHDF 1052
                    :.|.:.:.:....|...:...||  .|||::::.      :|..|:.:.|...::..
Human   930 --------SFFTSQNIMVTMINDSDYVSVAPHSAALNVMHSE------KDYVFAAVFNSTMVYSL 980

  Fly  1053 IWLNNASSMRRRYKRQNDPDYTDYSDYEIQEY-DVVVKPNSSSTSGQHNKSNPGDDNIITVQMSI 1116
            ..|.|..|....|..........:|....||. |:|.|                           
Human   981 PILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIVFK--------------------------- 1018

  Fly  1117 IEAASTLYNEKGKRKQLFGTLIIITA---YIALCLSIFSIFVTKERVEHFKM----QQEIYGVTL 1174
            ||    ||.:..    |.|  ||:||   |.|:           |..|:.|:    |.::.|:..
Human  1019 IE----LYFQAA----LLG--IIVTAMPPYFAM-----------ENAENHKIKAYTQLKLSGLLP 1062

  Fly  1175 FYFWSTHFVGD----FLIYAIYMGALTIAIYHFTIWYQVV----VMLLLIGF--ACLPFVYLCSL 1229
            ..:|....|.|    |:|..:.:|:|  ..:|:.:::..|    |:..|||:  :.:.|.|:.|.
Human  1063 SAYWIGQAVVDIPLFFIILILMLGSL--LAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASF 1125

  Fly  1230 LFS-----------LPNIAFAGIFAILVMTGGMLFSFMYMLTLITDVNFTTVFAILPMYVGTFGL 1283
            .|.           :.::|.....||..:|    |...|.:..|....|..:..|.|: :|....
Human  1126 TFKKILNTKEFWSFIYSVAALACIAITEIT----FFMGYTIATILHYAFCIIIPIYPL-LGCLIS 1185

  Fly  1284 FKCLAWREY-CNREVLPPIEELDCKFGNCNVFCACKPERTWMEVWLLMVHCLVWFIFLWFSNFGY 1347
            |..::|:.. .|.:...|.:.|.                  :.|....:.|::|...|.:    |
Human  1186 FIKISWKNVRKNVDTYNPWDRLS------------------VAVISPYLQCVLWIFLLQY----Y 1228

  Fly  1348 EIGYRFKPKLSNRIWHNNEKHIRVLDEERRVGLIPKYEHEDY----------------------P 1390
            |..|..:....:..:.|    :....:.|::...|..|.||.                      .
Human  1229 EKKYGGRSIRKDPFFRN----LSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPS 1289

  Fly  1391 IIVDQVTKNYCRAKN----------AVQLVSFAIRPGDTFGLLGAQGAGKTSIFQMIAGETSMSH 1445
            |:|..:.|.|...|:          |.:.:||.::.|:..||||..||||::|..::.|:...:.
Human  1290 IMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTS 1354

  Fly  1446 GNIYVRGHSLREHRNAAKME-VGFCPQGDNAPKYLTGRQLLRIHCLLHGVPKDHIKAVSEQMAIE 1509
            |.:::..:|.....:...:: :|:|||.:......|.::...|:..:.|:....:|.|..::...
Human  1355 GQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHA 1419

  Fly  1510 FNFKDQLDRPIHTYSGGKKRKLNIALA-IDSGSVLCLDDTNGSVDHATQRFIWRKLE-AVKRSGR 1572
            .:.|:.|.:.:.....|.||||..||: :.:..:..||:.:..:|...::.:||.:. |.|...|
Human  1420 LDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKR 1484

  Fly  1573 PVLLTTQSMEEANAVCSRVAFLVAGEMMFIGSLQQVRSEVSNTIVIRLRV-----NPSDGKLKRR 1632
            ..:|||..||||.|||.|||.:|:|::..||::|.::|:......:.:::     |....:|:|.
Human  1485 AAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQRE 1549

  Fly  1633 FQQLIADMAELFPLATLHEALETCLIYHI-NINVTTLANLFYQMEKIRNEGLLEDYSITQVSLDE 1696
            .|.       :||.|:..|:..:.|.|.| ..:|.:|:..|:::|:.::...:|:||.:|.:|::
Human  1550 IQY-------IFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQ 1607

  Fly  1697 IYRIL---NDEEDPNLVDLDST 1715
            ::..|   .:|||.:...|:||
Human  1608 VFVELTKEQEEEDNSCGTLNST 1629

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31213NP_001262752.1 ABC2_membrane_3 32..>295 CDD:289468 67/293 (23%)
ABC_subfamily_A 491..708 CDD:213230 71/222 (32%)
drrA 498..796 CDD:130256 95/303 (31%)
ABC2_membrane_3 <1132..1285 CDD:289468 41/180 (23%)
CcmA 1391..1672 CDD:224054 79/299 (26%)
ABC_subfamily_A 1391..1609 CDD:213230 65/230 (28%)
ABCA5NP_061142.2 ABC2_membrane_4 202..403 CDD:289500 51/220 (23%)
ABC2_membrane_3 <214..416 CDD:289468 54/223 (24%)
CcmA 476..788 CDD:224054 96/312 (31%)
ABC_subfamily_A 478..701 CDD:213230 71/222 (32%)
ABC2_membrane_3 <943..1224 CDD:289468 72/359 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1249..1268 5/18 (28%)
CcmA 1290..1615 CDD:224054 87/331 (26%)
ABC_subfamily_A 1290..1521 CDD:213230 65/230 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148354
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.850

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