DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31213 and ABCA6

DIOPT Version :10

Sequence 1:NP_732473.2 Gene:CG31213 / 42382 FlyBaseID:FBgn0051213 Length:1809 Species:Drosophila melanogaster
Sequence 2:NP_525023.2 Gene:ABCA6 / 23460 HGNCID:36 Length:1617 Species:Homo sapiens


Alignment Length:1861 Identity:415/1861 - (22%)
Similarity:781/1861 - (41%) Gaps:392/1861 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MNRNLTYCQKYRLLL------WKDIKLQLTNWVELVMIIFLSALMPIFFSIGTKVAKSIFPPDIE 59
            |.:...|.|...||.      |:..:..|..|       .||.|:.:..::.:...:::..|.:.
Human     3 MKQKSVYQQTKALLCKNFLKKWRMKRESLLEW-------GLSILLGLCIALFSSSMRNVQFPGMA 60

  Fly    60 MEKSPGPKSVNTSLFVDLYFTPNNGILEQLITQLANISEFKSVEVFDTNSELYLQLMINRN---A 121
            .:........|:|..:.:| ||.:.:.:|::.:.|.....|...|....::.::..::..|   |
Human    61 PQNLGRVDKFNSSSLMVVY-TPISNLTQQIMNKTALAPLLKGTSVIGAPNKTHMDEILLENLPYA 124

  Fly   122 IGIAFPSEWYDIKSCPEVLNLTIFMPLS--IKRKDF----------------KYFESGFLLLQER 168
            :||.| :|.:..|       |..|...:  :.::||                ||:..||:.||..
Human   125 MGIIF-NETFSYK-------LIFFQGYNSPLWKEDFSAHCWDGYGEFSCTLTKYWNRGFVALQTA 181

  Fly   169 ISKIFIFFKNAGNGKIPRVLMNHFPYPSYVPNHYAESAKAMTYMT--------LISFFL----PC 221
            |           |..|..:..|| |....:.:..|.:.|.:.::|        .|.|||    |.
Human   182 I-----------NTAIIEITTNH-PVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPL 234

  Fly   222 ITIAKYVVAEKERHQKAVLTAMGFSNSIHWLAWYTKSMLLLLLCLLIMISIFSIGLIYEFSSLVC 286
            :......|.::.:..|.::..||..:|..||:|.     |:....:.:|||| :.:|..|:.:: 
Human   235 VYFISLNVTKERKKSKNLMKMMGLQDSAFWLSWG-----LIYAGFIFIISIF-VTIIITFTQII- 292

  Fly   287 LMT-------IFLVYIHSLVLFAFFISSFFSRS-LSAVVATILMYFSTALPFLIVGAENSSVAAQ 343
            :||       :|.:|..|||...|.:|....:: |:.:|..:|..|...|.|.:...:       
Human   293 VMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQ------- 350

  Fly   344 TAASIGLNSALFYILDSVAVMEMQSVGAQWYTIDNTAS-------SGYKLSIVGYMLIMISISWI 401
                  |.|:|.:||:..:.....:...|...:|...:       ||...:::....:::....|
Human   351 ------LPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLLDGLI 409

  Fly   402 ELLICLYIEAVRTGEFEVPQPWSYPF-QRRYWCPLRY--GSSVF-HQGALLPLAGKNSEGNLPAA 462
            .||:.||.:.:            .|: ..|::.||.:  .||.| ||..    ..|..|..:.|.
Human   410 YLLLALYFDKI------------LPYGDERHYSPLFFLNSSSCFQHQRT----NAKVIEKEIDAE 458

  Fly   463 HPTRQPIIYLDDRTQENFQRV--NISKKIGIEVRSLSKTF----GFRNVVKDLFFNVYENEITAL 521
            ||:       ||    .|:.|  ....|..|.:|::.|.:    |....:|.|.|::||.:|||:
Human   459 HPS-------DD----YFEPVAPEFQGKEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAI 512

  Fly   522 VGHKGSGKTTIIMMLCGILQPTTGTVLINGYDI--VTEAKVAKSSLGICPQHSVIFKGMSARDHI 584
            :||.|:||::::.:|.|:..||.|:|.|...::  :.:.:..:...|:|||.:|.|..::.::::
Human   513 LGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENL 577

  Fly   585 YFFSRVKGYNKTEAMMESNIYISKLGLVDSQKWDAMRLSPGNQRRLSLACALCAGSKVILCDEPS 649
            ..|:::||.:..|...|....:.:|.:.:.|...|..||.|.:|:|:....:....:::|.|||:
Human   578 SLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPT 642

  Fly   650 SGLDPIGRHELMRFLQKEKHGRTILMTTQQLEEGEILADRIAIMNDGQILCYGTLGYLKQLPFTS 714
            :||||..|.::...|::.:....||.:||.::|.:|||||..||::|::.|.|:..:||:.....
Human   643 TGLDPFSRDQVWSLLRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLG 707

  Fly   715 YTLSCQMAPNSKADNLTDLVRLYMTTTTSPVFHGVDVSYKLPRSQIDRFPEFFQQLEENKKSLNV 779
            |.||.........:.:|..:..::........:...:.|.||..:.:.||:.|..|::.... .|
Human   708 YHLSLHRNEICNPEQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSDQ-GV 771

  Fly   780 VSFGVSDSTLDGIYLSLDYGQGSSRLRGGADPGVNDKVEFGVQTDKAIRTKDRANNSLVRYQHQV 844
            ..:.:|.|||:.:::.|: ||.:              :|...:..:.||..:..|        ::
Human   772 TGYDISMSTLNEVFMKLE-GQST--------------IEQDFEQVEMIRDSESLN--------EM 813

  Fly   845 DPPNETILNTKTPINPIEIWRPIDREKGSCMAQWQAMFIKKKNYTASRALIFILILI-IPLFYYI 908
            :..:.:....:|.::.:.:||.      ...|..:..|:|.|..|  :.|:.:|::. |.:|..|
Human   814 ELAHSSFSEMQTAVSDMGLWRM------QVFAMARLRFLKLKRQT--KVLLTLLLVFGIAIFPLI 870

  Fly   909 I--VLGTAASEKCAHRTDKQPVLPLSLDYYSYDDMIILLEVDKQLY-KSEGEAYVQLVKEPAT-- 968
            :  ::....:||              :|:          |...:|| .|.|    ||.:||.|  
Human   871 VENIMYAMLNEK--------------IDW----------EFKNELYFLSPG----QLPQEPRTSL 907

  Fly   969 --VESVDSIFSHLLKAPPIIRRDI--------KRKYVCGASFNNASTITAWFNSDAFEHSAPIAL 1023
              :.:.:|.....:|:  :..::|        .|....|.|:|.|..::                
Human   908 LIINNTESNIEDFIKS--LKHQNILLEVDDFENRNGTDGLSYNGAIIVS---------------- 954

  Fly  1024 NLVYNALGKAVFEDQDFSILVNRGDLHDFIWLNNASSMRRRYKRQNDPDYTDYSDYEIQEYDVVV 1088
                   ||.  :|..||::.|...||.|..|.|.                 .|:..:|.::   
Human   955 -------GKQ--KDYRFSVVCNTKRLHCFPILMNI-----------------ISNGLLQMFN--- 990

  Fly  1089 KPNSSSTSGQHNKSNPGDDNIITVQMSIIEAASTLYNEKGKRKQLFGTLIIITAYIALCLSIFSI 1153
                   ..||.:               ||::....:..|    |:..|...:.::.|.|...|.
Human   991 -------HTQHIR---------------IESSPFPLSHIG----LWTGLPDGSFFLFLVLCSISP 1029

  Fly  1154 FVTKERVEHF----KMQQEIYGVTLFYFWSTHFVGDFLIYAIYMGALTIAIYHFTIWYQVVVMLL 1214
            ::|...:..:    |.|..|.|:....:|....:.|...:.:.:..:.:..|...:.|.::...:
Human  1030 YITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIFYIENMQYLLITSQI 1094

  Fly  1215 LIGFACLPFVYLCSLLFSLPNIAFAGIFAILVMTGGMLFSF--------MYMLTLITDVNFT--- 1268
            :.....:...|..||:|.:..|:|  ||.......| |:||        |:.:|||...:.:   
Human  1095 VFALVIVTPGYAASLVFFIYMISF--IFRKRRKNSG-LWSFYFFFASTIMFSITLINHFDLSILI 1156

  Fly  1269 TVFAILPMYVGTFGLFKCLA-------WREY--CNREVLPPIEELDCKFGNCNVFCACKPERTWM 1324
            |...::|.|  |...||...       :||:  .|.|:            :...|..|.......
Human  1157 TTMVLVPSY--TLLGFKTFLEVRDQEHYREFPEANFEL------------SATDFLVCFIPYFQT 1207

  Fly  1325 EVWLLMVHCLVWFIFLWFSNFGYEIG---------YRFKPKLSNRIWHNNEKHIRVLDEERRV-- 1378
            .:::.::.|:           ..:.|         :|..|: |.....|.|:.|   ||:..:  
Human  1208 LLFVFVLRCM-----------ELKCGKKRMRKDPVFRISPQ-SRDAKPNPEEPI---DEDEDIQT 1257

  Fly  1379 -------GLIPKYEHEDYPIIVDQVTKNYC----------RAKNAVQLVSFAIRPGDTFGLLGAQ 1426
                   .|......|...||...:.|.|.          :.|.|.:.:||.::.|:..||||..
Human  1258 ERIRTATALTTSILDEKPVIIASCLHKEYAGQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPN 1322

  Fly  1427 GAGKTSIFQMIAGETSMSHGNIYVRG-HSLREHRNAAKMEVGFCPQGDNAPKYLTGRQLLRIHCL 1490
            ||||:|..:||:|.|..:.|.:.::| .|:..|       :|:|||.:.....||.|:.|.::..
Human  1323 GAGKSSSIRMISGITKPTAGEVELKGCSSVLGH-------LGYCPQENVLWPMLTLREHLEVYAA 1380

  Fly  1491 LHGVPKDHIKAVSEQMAIEFNFKDQLDRPIHTYSGGKKRKLNIALAIDSGS-VLCLDDTNGSVDH 1554
            :.|:.|...:....::...|...:||:.|:...:.|..|||...|::...| ||.||:.:..:|.
Human  1381 VKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDP 1445

  Fly  1555 ATQRFIWRKLEA-VKRSGRPVLLTTQSMEEANAVCSRVAFLVAGEMMFIGSLQQVRSEVSNTIVI 1618
            ..|:.:|:.::| ||.:.|.|||||.::.||.|:|.|||.:|:|.:..|||:|.:::::....::
Human  1446 TGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYIL 1510

  Fly  1619 RLRVNPSDGKLKRRFQQLIADMAELFPLATLHEALETCLIYHINI-NVTTLANLFYQMEKIRNEG 1682
            .|:|     |...:...:..::.:|||.|...|...:.|.|.:.: :|..|:..|:::|.:::..
Human  1511 ELKV-----KETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNF 1570

  Fly  1683 LLEDYSITQVSLDEIYRILNDEEDPNLVD--LDSTHNSEVL 1721
            .||:||::|.:|::::..|:.|::....|  :|:|...::|
Human  1571 NLEEYSLSQCTLEKVFLELSKEQEVGNFDEEIDTTMRWKLL 1611

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31213NP_732473.2 rim_protein <118..1698 CDD:130324 388/1711 (23%)
ABCA6NP_525023.2 rim_protein <174..1593 CDD:130324 376/1654 (23%)

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