DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31213 and ABCA2

DIOPT Version :9

Sequence 1:NP_001262752.1 Gene:CG31213 / 42382 FlyBaseID:FBgn0051213 Length:1809 Species:Drosophila melanogaster
Sequence 2:NP_997698.1 Gene:ABCA2 / 20 HGNCID:32 Length:2466 Species:Homo sapiens


Alignment Length:1998 Identity:463/1998 - (23%)
Similarity:823/1998 - (41%) Gaps:424/1998 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 VDLY--FTPNNGILEQLITQL--ANISEFKSVEVFDTNSELYLQLMINRNAIGIAFPSEWYDIK- 134
            ||::  |.....|:...:.|.  .|::.|.|| :|.|..:            |...|...|.|: 
Human   607 VDIFKGFPDEESIVNYTLNQAYQDNVTVFASV-IFQTRKD------------GSLPPHVHYKIRQ 658

  Fly   135 --SCPEVLNLTIFMPLSIKRKDFK---------YFESGFLLLQERISKIFI--FFKNAGNGKI-P 185
              |..|..|       .|:|..::         ||..||:.:|:.:.:..|  |   .|:..: |
Human   659 NSSFTEKTN-------EIRRAYWRPGPNTGGRFYFLYGFVWIQDMMERAIIDTF---VGHDVVEP 713

  Fly   186 RVLMNHFPYPSYVPNHYAESAKAMTYMTLISFFLP-CITIA---------KYVVAEKERHQKAVL 240
            ...:..||||.|..:         .::.:|...:| |:.|:         :::|||||...|.|:
Human   714 GSYVQMFPYPCYTRD---------DFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVM 769

  Fly   241 TAMGFSNSIHWLAWYTKSMLLLLLCLLIMISIFSIGLIYEFSSLVCLMTIFLVYIHSLVLFAFFI 305
            ..||.:|::||:||:....:.|.:.:..:.:|...|.:...|.:|.:.....||..:.::|.|.:
Human   770 KTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCFLV 834

  Fly   306 SSFFSRSLSAVVATILMYFSTALPFL------------IVGAENSSVAAQTAASIGLNSALFYIL 358
            |..:|::..|.....::||.:.:|::            |...|....:..:..:.||.|..|   
Human   835 SVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLGSKYF--- 896

  Fly   359 DSVAVMEMQSVGAQWYTIDNTASSG--YKLSIVGYMLIMISISWIELLICLYIEAVRTGEFEVPQ 421
               |:.|:..||.||:|...:...|  :.|.:...||::.::  :..::..|||||..|.:.:|:
Human   897 ---ALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAV--VYGILTWYIEAVHPGMYGLPR 956

  Fly   422 PWSYPFQRRYWCPLRYGS------------------SVFHQGALLPLAGKN-SEGNLPAAHPTRQ 467
            ||.:|.|:.||    .||                  ||..:.....:..:. .|.......||..
Human   957 PWYFPLQKSYW----LGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEEEPTHL 1017

  Fly   468 PIIYLDDRTQENFQRVNISKKIGIEVRSLSKTFGFRNVVKDLFFNVYENEITALVGHKGSGKTTI 532
            |::...|:..:.::.   .||:.:...||               |:|||::.:.:||.|:||||.
Human  1018 PLVVCVDKLTKVYKD---DKKLALNKLSL---------------NLYENQVVSFLGHNGAGKTTT 1064

  Fly   533 IMMLCGILQPTTGTVLINGYDIVTEAKVAKSSLGICPQHSVIFKGMSARDHIYFFSRVKGYNKTE 597
            :.:|.|:..||:|:..|.|:||.||....:.:||:||||:|:|..::..:|::|:||:|...:.|
Human  1065 MSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEE 1129

  Fly   598 AMMESNIYISKLGLVDSQKWDAMRLSPGNQRRLSLACALCAGSKVILCDEPSSGLDPIGRHELMR 662
            ...|.:..|..|.|.:.:......||.|.:|:||:|.|...||:.|:.|||::|:||..|..:..
Human  1130 IRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWD 1194

  Fly   663 FLQKEKHGRTILMTTQQLEEGEILADRIAIMNDGQILCYGTLGYLKQLPFTSYTLSC-------- 719
            .:.|.|.|||||::|..::|.::|.|||||::.|::.|.|:..:||......|.|:.        
Human  1195 LILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPG 1259

  Fly   720 ------------QMAPNSKADNL--TDLVRLYMTTTTSPVFHGVDVSYKLPRSQIDR--FPEFFQ 768
                        ..||.|....|  :..:|.::.:.........::||.||.....:  |...||
Human  1260 GPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQ 1324

  Fly   769 QLEENKKSLNVVSFGVSDSTLDGIYL-------SLDYGQGSSR------LRGGADPGVND----- 815
            .||.:..:|::.|||:.|:||:.::|       ||:..:...:      |.|...|...:     
Human  1325 HLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDVLPGAEGPASGEGHAGN 1389

  Fly   816 --------KVEFGVQTDKAI---RTKDRANNSLV------RYQHQVDPPNETILNTKTPINPIEI 863
                    :.:..:|:..::   |..:.|..:.|      .:.:..||.|.::            
Human  1390 LARCSELTQSQASLQSASSVGSARGDEGAGYTDVYGDYRPLFDNPQDPDNVSL------------ 1442

  Fly   864 WRPIDRE------KGS--------CMAQWQAMFIKKKNYTASRALIFILILIIPLFYYIIVLGTA 914
             :.::.|      :||        .:.|:..:.:|:.:.....:......:::|.|:..:.:..|
Human  1443 -QEVEAEALSRVGQGSRKLDGGWLKVRQFHGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVA 1506

  Fly   915 ASEKCAHRTDKQPVLPLSLDYYSY----DDMIILLEVDKQLYK------SEGEAYVQLVKEPATV 969
            .|  .....|..|::.....|::|    .:.|.....:::.|:      :..:..|...:.|:.|
Human  1507 LS--VPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGV 1569

  Fly   970 ESVDSIFSHLLKAP------PIIRRDIKRKYVCGASFNNASTITAWFNSDAFEHSAPIALNLVYN 1028
            .:     :.:||:|      |.:........:..|.|.::..:      ::|....|:: |.|..
Human  1570 GA-----TCVLKSPANGSLGPTLNLSSGESRLLAARFFDSMCL------ESFTQGLPLS-NFVPP 1622

  Fly  1029 ALGKAVFE-----DQDF-----SILVNRGDLHDFIWLNNASSMRRRYKRQ--------------- 1068
            ....|..:     |:|.     |:....|   ..:| .:|.|:.|..:..               
Human  1623 PPSPAPSDSPASPDEDLQAWNVSLPPTAG---PEMW-TSAPSLPRLVREPVRCTCSAQGTGFSCP 1683

  Fly  1069 -----NDPD--------YTDYSDYEIQEYDVVVKPN------SSSTSGQHNKSNPGDDNI----I 1110
                 :.|.        .||.:.:.:.||.:.....      .:.|.|...||.|.....    :
Human  1684 SSVGGHPPQMRVVTGDILTDITGHNVSEYLLFTSDRFRLHRYGAITFGNVLKSIPASFGTRAPPM 1748

  Fly  1111 TVQMSIIEAASTLYNEKGKRKQ------------------------------------------- 1132
            ..::::..||...||.||....                                           
Human  1749 VRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLS 1813

  Fly  1133 ----LFGTLIIITAYIALCLSI----FSIFVTKERVEHFKMQQEIYGVTLFYFWSTHFVGDFLIY 1189
                |.||.::|..:|.:.:|.    |.:|:..|:....|..|.:.|.....:|..::|.|.|.|
Human  1814 LDYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNY 1878

  Fly  1190 AIYMGALTIAIYHF--------TIWYQVVVMLLLIGFACLPFVYLCSLLFSLPNIAFAGIFAILV 1246
            .:......|.::.|        |.:..|:.:.||.|::..|.:|..|..|.:|:.|:..:..|.:
Human  1879 LVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINL 1943

  Fly  1247 MTGGMLFSFMYMLTL--------ITDVNFTTVFAILPMYVGTFGLFKCLAWREYCNREVLPPIEE 1303
            ..|.......::|.|        :.:....:.|.|.|.|....||.: :|:.||.|        |
Human  1944 FIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLME-MAYNEYIN--------E 1999

  Fly  1304 LDCKFGNCNVFCACKPERTWMEVW----LLMVHCLVWFIFLWFSNFGYEIGYRFKPKLSNRIWHN 1364
            ...|.|.   |...|....|..|.    .:.|..:|.|:......:.:....:..|..:..:   
Human  2000 YYAKIGQ---FDKMKSPFEWDIVTRGLVAMAVEGVVGFLLTIMCQYNFLRRPQRMPVSTKPV--- 2058

  Fly  1365 NEKHIRVLDEERRVGLIPKYEHEDYPIIVDQVTKNYCRAK----NAVQLVSFAIRPGDTFGLLGA 1425
             |..:.|..|.:||   .:.:.::..:.::.:||.|...|    .||..:...:|||:.|||||.
Human  2059 -EDDVDVASERQRV---LRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGV 2119

  Fly  1426 QGAGKTSIFQMIAGETSMSHGNIYVRGHSLREHRNAAKMEVGFCPQGDNAPKYLTGRQLLRIHCL 1490
            .||||||.|:|:.|:.|.:.|..:|.|||:.:.....:..:|:|||.|.....||.|:.|:::..
Human  2120 NGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTR 2184

  Fly  1491 LHGVP-KDHIKAVSEQMAIE-FNFKDQLDRPIHTYSGGKKRKLNIALA-IDSGSVLCLDDTNGSV 1552
            |.|:. ||..:.|  :.|:| .......|:|..|||||.||||:.|:| |...:.:.||:....:
Human  2185 LRGISWKDEARVV--KWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGM 2247

  Fly  1553 DHATQRFIWRKLEAVKRSGRPVLLTTQSMEEANAVCSRVAFLVAGEMMFIGSLQQVRSEVSNTIV 1617
            |...:||:|..:..:.::||.|:||:.||||..|:|:|:|.:|.|.:..:||:|.:::...:..:
Human  2248 DPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYM 2312

  Fly  1618 IRLRVNPSDGKLKRRFQQLIADMAEL----FPLATLHEALETCLIYHININVTTLANLFYQMEKI 1678
            |.:|...|         |.:.|:...    ||.|.|.|...|.:.|.:.....:||.:|.:||::
Human  2313 ITVRTKSS---------QSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQV 2368

  Fly  1679 RNEGLLEDYSITQVSLDEIYRILNDEEDPNLVDLDSTHNSEVLEDIRDTTRDTTRGTTRDTN--- 1740
            .....:||||::|.:||.::.....::..|| :...|.....|:..........|..:..|.   
Human  2369 SGVLGIEDYSVSQTTLDNVFVNFAKKQSDNL-EQQETEPPSALQSPLGCLLSLLRPRSAPTELRA 2432

  Fly  1741 LVSDEGIQKEKVKRKKVEEEDRDRQESTETSKPKVKRSPATQSDSTDT 1788
            ||:|             |.||.|.::....|   .:...|..|.:|||
Human  2433 LVAD-------------EPEDLDTEDEGLIS---FEEERAQLSFNTDT 2464

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31213NP_001262752.1 ABC2_membrane_3 32..>295 CDD:289468 58/248 (23%)
ABC_subfamily_A 491..708 CDD:213230 78/216 (36%)
drrA 498..796 CDD:130256 102/328 (31%)
ABC2_membrane_3 <1132..1285 CDD:289468 40/219 (18%)
CcmA 1391..1672 CDD:224054 97/291 (33%)
ABC_subfamily_A 1391..1609 CDD:213230 83/224 (37%)
ABCA2NP_997698.1 rim_protein 58..2398 CDD:130324 444/1913 (23%)
ABC_subfamily_A 1021..1240 CDD:213230 81/236 (34%)
ABC_subfamily_A 2081..2304 CDD:213230 83/224 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148362
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.860

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