DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG31213 and ABCA1

DIOPT Version :9

Sequence 1:NP_001262752.1 Gene:CG31213 / 42382 FlyBaseID:FBgn0051213 Length:1809 Species:Drosophila melanogaster
Sequence 2:NP_005493.2 Gene:ABCA1 / 19 HGNCID:29 Length:2261 Species:Homo sapiens


Alignment Length:2061 Identity:481/2061 - (23%)
Similarity:839/2061 - (40%) Gaps:551/2061 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 RLLL--------WKDIKLQLTNWVELVMIIFLSALMPIFFSIGTKVAKSIFPPDIEMEKSPGPKS 68
            |:||        |:. :|...:|....::.||:.                .|.|::        |
Human   437 RMLLDSRDNDHFWEQ-QLDGLDWTAQDIVAFLAK----------------HPEDVQ--------S 476

  Fly    69 VNTSLFV--DLYFTPNNGI--------------LEQLITQLANISEFKSVEVFDTNSELYLQLMI 117
            .|.|::.  :.:...|..|              ||.:.|::..|:  ||:|:.|.          
Human   477 SNGSVYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLIN--KSMELLDE---------- 529

  Fly   118 NRNAIGIAFPSEWYDIKSCPEVLNLTIFMPL-SIKR------------------KDFKYFESGFL 163
            .:...||.|..........|..:...|.|.: :::|                  :|.:|...||.
Human   530 RKFWAGIVFTGITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFA 594

  Fly   164 LLQERISKIFIFFKNAGNGKIPRVLMNHFPYPSYVPNHYAE-SAKAMTYMTLISFFLPCITIAKY 227
            .||:.:.:..|... .|..|...|.|...|||.||.:.:.. .:::|.....:::......|.|.
Human   595 YLQDVVEQAIIRVL-TGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKG 658

  Fly   228 VVAEKERHQKAVLTAMGFSNSIHWLAWYTKSMLLLLLCLLIMISIFSIGLIYEFSSLVCLMTIFL 292
            :|.|||...|..:..||..|||.|.:|:..|::.||:...:::.|..:|.:..:|....:.....
Human   659 IVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLS 723

  Fly   293 VYIHSLVLFAFFISSFFSRSLSAVVATILMYFSTALPFLIVGAENSSV--AAQTAASIGLNSALF 355
            |:....:|..|.||:.|||:..|.....::||:..||:::..|....|  ..:..||:....|..
Human   724 VFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFASLLSPVAFG 788

  Fly   356 YILDSVAVMEMQSVGAQWYTIDNTASS-----GYKLSIVGYMLIMIS-----ISWIELLICLYIE 410
            :..:..|:.|.|.:|.||   ||...|     |:.|:....|::..:     ::|       |||
Human   789 FGCEYFALFEEQGIGVQW---DNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTW-------YIE 843

  Fly   411 AVRTGEFEVPQPWSYPFQRRYWCPLRYGSSVFHQGALLPLAGKNSEGNLPAAHPTRQPIIYLDDR 475
            ||..|::.:|:||.:|..:.||    :|.             ::.|.:.|.::..|...|.:::.
Human   844 AVFPGQYGIPRPWYFPCTKSYW----FGE-------------ESDEKSHPGSNQKRISEICMEEE 891

  Fly   476 TQENFQRVNISKKIGIEVRSLSKTF--GFRNVVKDLFFNVYENEITALVGHKGSGKTTIIMMLCG 538
            ...        .|:|:.:::|.|.:  |.:..|..|..|.||.:||:.:||.|:||||.:.:|.|
Human   892 PTH--------LKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTG 948

  Fly   539 ILQPTTGTVLINGYDIVTEAKVAKSSLGICPQHSVIFKGMSARDHIYFFSRVKGYNKTEAMMESN 603
            :..||:||..|.|.||.:|....:.:||:||||:|:|..::..:||:|::|:||.::.....|..
Human   949 LFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEME 1013

  Fly   604 IYISKLGLVDSQ-KWDAMRLSPGNQRRLSLACALCAGSKVILCDEPSSGLDPIGRHELMRFLQKE 667
            .....:||..|: |....:||.|.||:||:|.|...||||::.|||::|:||..|..:...|.|.
Human  1014 QMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKY 1078

  Fly   668 KHGRTILMTTQQLEEGEILADRIAIMNDGQILCYGTLGYLKQLPFTSYTL------------SCQ 720
            :.||||:::|..::|.::|.|||||::.|::.|.|:..:||....|.|.|            ||:
Human  1079 RQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCR 1143

  Fly   721 -----------------------MAPNSKADNLT-------DLVRLYMTTTTSPVFHGVDVSYKL 755
                                   :..:.::|.||       :|:|.:::........|.:::|.|
Human  1144 NSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVL 1208

  Fly   756 P--RSQIDRFPEFFQQLEENKKSLNVVSFGVSDSTLDGIYLSLDYGQG-SSRLRGGADPGVNDKV 817
            |  .::...|.|.|.::::....|.:.|:|:|::||:.|:|.:....| .:....|..|...::.
Human  1209 PYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRR 1273

  Fly   818 EFGVQTDK--AIR--TKDRANNSLVRYQHQVDPPNETILNTKTPINPIEIWRPIDRE-------- 870
            .||   ||  .:|  |:|.|.:           ||::.::            |..||        
Human  1274 AFG---DKQSCLRPFTEDDAAD-----------PNDSDID------------PESRETDLLSGMD 1312

  Fly   871 -KGSCMAQ-------------WQAMFI---KKKNYTASRAL--IFILI-----LIIPLFYYIIVL 911
             |||...:             |:.:.|   .:|.:.|...|  :|:.|     ||:|.|      
Human  1313 GKGSYQVKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPF------ 1371

  Fly   912 GTAASEKCAHRTDKQPVLPLSLDYYSYDDMIIL-----------LEVDKQLYKSEG--------- 956
                        .|.|  .|.|..:.|::....           ||:...|.|..|         
Human  1372 ------------GKYP--SLELQPWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGN 1422

  Fly   957 --------------------EAYVQLVK---------EPATVESVDSIFSHLLKAPP-------- 984
                                :..:.|.:         .||...|.|.|...|...||        
Human  1423 PIPDTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPP 1487

  Fly   985 ----------------------------IIRRDIKRK----------YVCGASFNNA-------- 1003
                                        ||.:.:|.|          :..|.|...|        
Human  1488 QRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVN 1552

  Fly  1004 -----------------------------------STITAWFNSDAFEHSAPIALNLVYNALGKA 1033
                                               :.:..|||:..: |:....||::.||:   
Human  1553 DAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGW-HAISSFLNVINNAI--- 1613

  Fly  1034 VFEDQDFSILVNRGDLHDFIWLNNASSMRRRYKRQNDPDYTDYSDYEIQEYDVVVKPNSSSTSGQ 1098
                                       :|...::..:|     |.|.|..::..:          
Human  1614 ---------------------------LRANLQKGENP-----SHYGITAFNHPL---------- 1636

  Fly  1099 HNKSNPGDDNIITVQMSIIEAASTLYNEKGKRKQLFGTLIIITAYIALCLSI----FSIFVTKER 1159
                     |:...|:|.:...:|..:            ::::..:...:|.    |.:|:.:||
Human  1637 ---------NLTKQQLSEVALMTTSVD------------VLVSICVIFAMSFVPASFVVFLIQER 1680

  Fly  1160 VEHFKMQQEIYGVTLFYFWSTHFVGDFLIYAIYMGALTIAIYHFTIWYQ-----------VVVML 1213
            |...|..|.|.||....:|.::||.|...|.:   ..|:.|..|..:.|           :.::|
Human  1681 VSKAKHLQFISGVKPVIYWLSNFVWDMCNYVV---PATLVIIIFICFQQKSYVSSTNLPVLALLL 1742

  Fly  1214 LLIGFACLPFVYLCSLLFSLPNIAFAGIFAILVMTG--GMLFSFMYMLTLITD-----VN--FTT 1269
            ||.|::..|.:|..|.:|.:|:.|:..:.::.:..|  |.:.:|  :|.|.||     :|  ..:
Human  1743 LLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATF--VLELFTDNKLNNINDILKS 1805

  Fly  1270 VFAILPMYVGTFGLFKCLAWREYCNREVLPPIEELDCKFGNCNVFCACKPERTWMEVWLLMVHCL 1334
            ||.|.|.:....||...:.     |:.:...:|    :||..........:.....::.:.|..:
Human  1806 VFLIFPHFCLGRGLIDMVK-----NQAMADALE----RFGENRFVSPLSWDLVGRNLFAMAVEGV 1861

  Fly  1335 VWFIFLWFSNFGYEIGYRF--KPKLSN-RIWHNNEKHIRVLDEERRV----GLIPKYEHEDYPII 1392
            |:|:....      |.|||  :|:..| ::...|::...|..|.:|:    |       ::..:.
Human  1862 VFFLITVL------IQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGG-------QNDILE 1913

  Fly  1393 VDQVTKNYCR-AKNAVQLVSFAIRPGDTFGLLGAQGAGKTSIFQMIAGETSMSHGNIYVRGHSLR 1456
            :.::||.|.| .|.||..:...|.||:.|||||..||||:|.|:|:.|:|:::.|:.::..:|:.
Human  1914 IKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSIL 1978

  Fly  1457 EHRNAAKMEVGFCPQGDNAPKYLTGRQLLRIHCLLHGVPKDHIKAVSEQMAIEFNFKDQLDRPIH 1521
            .:.:.....:|:|||.|...:.||||:.:....||.|||:..:..|.|....:.......::...
Human  1979 SNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAG 2043

  Fly  1522 TYSGGKKRKLNIALAIDSG-SVLCLDDTNGSVDHATQRFIWRKLEAVKRSGRPVLLTTQSMEEAN 1585
            .||||.||||:.|:|:..| .|:.||:....:|...:||:|....:|.:.||.|:||:.||||..
Human  2044 NYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECE 2108

  Fly  1586 AVCSRVAFLVAGEMMFIGSLQQVRSEVSN--TIVIRLRVNPSDGKLKRRFQQLIADMAELFPLAT 1648
            |:|:|:|.:|.|....:||:|.:::...:  |||:|:..:..|.|..:.|..|      .||.:.
Human  2109 ALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGL------AFPGSV 2167

  Fly  1649 LHEALETCLIYHININVTTLANLFYQMEKIRNEGLLEDYSITQVSLDEIY-RILNDE-EDPNLVD 1711
            |.|.....|.|.:..::::||.:|..:.:.:....:||||::|.:||::: ....|: :|.:|.|
Human  2168 LKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKD 2232

  Fly  1712 LDSTHNSEVLEDIRDTTRDTTRGTTRDTNLVSDEGIQKEKVKRKKV 1757
            | |.|.::.:.|:                .|....:|.||||...|
Human  2233 L-SLHKNQTVVDV----------------AVLTSFLQDEKVKESYV 2261

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31213NP_001262752.1 ABC2_membrane_3 32..>295 CDD:289468 62/298 (21%)
ABC_subfamily_A 491..708 CDD:213230 84/219 (38%)
drrA 498..796 CDD:130256 110/344 (32%)
ABC2_membrane_3 <1132..1285 CDD:289468 44/176 (25%)
CcmA 1391..1672 CDD:224054 95/284 (33%)
ABC_subfamily_A 1391..1609 CDD:213230 79/219 (36%)
ABCA1NP_005493.2 rim_protein 6..2236 CDD:130324 472/2018 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1283..1312 9/51 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.930

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