DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31213 and abt-1

DIOPT Version :9

Sequence 1:	NP_001262752.1	Gene:	CG31213 / 42382	FlyBaseID:	FBgn0051213	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	NP_001293854.1	Gene:	abt-1 / 182849	WormBaseID:	WBGene00000019	Length:	1558	Species:	Caenorhabditis elegans

Alignment Length:	1778	Identity:	325/1778 - (18%)
Similarity:	607/1778 - (34%)	Gaps:	497/1778 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 KSVEVFDTNSELYLQLMINRNAIGIAFPSEWYDIKSCPEVLNLTIFMPLSIKRKD---FKYFESG 161
            |.:..|.:|...::.:.|   .:.:||.:.|:...            |...:..|   |..|::
Worm    21 KDLNYFRSNHPFFILIFI---VLSLAFYNVWWHNS------------PTRDQSGDASKFHLFDN- 69

  Fly   162 FLLLQERISKIFIFFKNA-----GNGKIPRVLMNHFPYPSYVPNHYAESAK----------AMTY 211
            |.|.:::..|:.:.....     .:..|..:.:.|..||........|.||          .:.:
Worm    70 FRLSKQKFVKMIVCIPETVVDYRFSTVIDAIHLTHLDYPHLEFTKKLEKAKNKLEDGEVDFLVLF 134

  Fly   212 MTLIS---------------FFLPCITIAKYVVAEKERHQKAVLTAMGFSNSIHWLA-------- 253
            .|||.               |...||   :..|..|:....||...:..:..::||.
Worm   135 KTLIETGKKIEYKIISEQGVFDKHCI---QCDVHRKKTWGNAVEAQVVVNRFLYWLVKSRGFNKR 196

  Fly   254 ---W-----YTK------------SMLLLLLCLLI-----MISIF----SIGLIYEFSSL----- 284
               |     |.|            |.|.||..||:     :|.::    |.|....|.||
Worm   197 SPHWQLSNVYVKHSGNDPMFLKRQSDLFLLWILLLPICSRLIDLWNNDRSSGYYNMFLSLHARRF 261

  Fly   285 ------------VCLMTIFLVYI-HSLVLFAFFISSF--FSRSLSAVVATILMYFSTALPFLIVG 334
                        :.|:...:|:| :.||:.|.|.|::  |....:|.:.:..::.:|..|...:.
Worm   262 HYFIAKFVFWYGIALIISLIVFIVNVLVVPAVFCSTYLQFVVCYAACIISFAIFLATTFPGSPLF 326

  Fly   335 AENSSVAAQTAASIGLNSAL----FYILDSVAVMEMQSVGAQWYTIDNTASSGYKLSIVGYMLIM 395
            |:.....:..|...|..:..    |:.| .|...........|  ||...:    |.:.|..:::
Worm   327 AKIVGFLSMVAGEFGFGTVYHGIGFFQL-CVRHFGKSEFDGPW--IDAVCT----LCMTGNCVLL 384

  Fly   396 ISIS-WIELLICLYIEAVRTGEFEVPQPWSYPFQRRYWCPLRYGSSV--FHQGALLPLAGKNSEG 457
            |::| :.:...||:     |.|   |..:.:|.::.||.|......:  |....::.|....||.
Worm   385 ITVSIYFDTYFCLF-----TME---PLAFYFPLEKDYWMPEARSPQLDTFFVKQIILLKPGRSEI 441

  Fly   458 NLPAAH----------------PT----RQPIIYLDDRTQENFQRVNISKKIGIEVRSLSKTFGF 502
            .:..||                ||    ..|::.|          ..|.|:|....|
Worm   442 TVKKAHDEILPAKTSTGSKYIPPTPIVKGVPLVVL----------YGICKRIENHWR-------- 488

  Fly   503 RNVVKDLFFNVYENEITALVGHKGSGKTTIIMMLCGILQPTTGTVLINGYDIVTEAKVAKSSLGI 567
               ||.:...|:..|:..|.||.|.|...|:.::.|.::|..|.|::.    .::..:..|....
Worm   489 ---VKQVSLTVHLGEVVTLYGHHGCGSGEILSIIAGQMKPEYGEVMME----QSQRPLMISKTTD 546

  Fly   568 CPQHSVIFKGMSARDHIYFFSRVKGYNKTEAMMESNIYISKLGLVDSQKWDAMRLSPGNQRRLSL 632
            .|..:.    ::...::...|:::|.:.:.:.::.  .:.:|.|:..:......||...:.||.:
Worm   547 VPNVNY----LNVIQYLRLISKMRGVSASTSHIDE--MLEELDLIKVKNRSLDLLSTTQKERLRI 605

  Fly   633 ACALCAGSKVILCDEPSSGLDPIGRHELMRFLQKEKHGRTILMTTQQLEEGEILADRIAIMNDGQ 697
            |........::|.|.|:....|..:..:.||::|.|..|:|::::...||.|.::|::.:|::|.
Worm   606 AAVFVGQPDLVLIDFPTMECLPEWKFMVFRFIEKRKEKRSIIVSSYDPEETEAISDKVVLMSEGY 670

  Fly   698 ILCYGTLGYLKQL-------------PFTSYTLSCQMAPNSKADNLTDLVRLYMTTTTSPVFHGV 749
            ::..|:....|..             .||...:...|...:..||.......:..|....:...:
Worm   671 VVLNGSCEAFKHSINSVFEIRIWPNNRFTDEQIKGMMKTLTLGDNQMKNDARFFETPNGKIRVTL 735

  Fly   750 DVSYKLPRSQIDRFPEFFQQLEENKKSLNVVSFGVSDSTLDGIYLSLDYGQGSSRLRGGADPGVN 814
            .:.|:  ||    .|...::|:...:...:..:.:....:..||.:..|....      .||
Worm   736 PILYR--RS----IPLILRELDAVHEKFRIEFYELGKPNIHDIYANACYEHQQ------LDP--- 785

  Fly   815 DKVEFGVQTDKAIRTKDRANNSLVRYQHQVDPPNETILNTKTPI--NPIEIWRPIDREKGSCMAQ 877
                        :.|.|:..:...:.|.         ||.||..  |.|.|::     .|..:.:
Worm   786 ------------LSTFDQLRDHYTKQQP---------LNKKTYFFKNMIHIFK-----DGRFLIE 824

  Fly   878 WQAMFIKKKNYTASRALIFILILIIPLFYYIIVLGTAASEKCAHRTDKQPVLPLSLDYYSYDDMI 942
            ..|:.          .|..||.:||.|.|:.:       |..:|:|.:     :||..|.....|
Worm   825 TAAVV----------GLFLILTVIILLSYHSV-------ESDSHQTRE-----ISLTSYESPITI 867

  Fly   943 ILLEVDKQLYKSEGEAYVQLVKEPATVESVDSIFSHLLKAPPIIRRDIKRKYVCGASFNNASTIT 1007
            ...|.:|::.:                                           |.:|...|.:.
Worm   868 YCDECEKEVIE-------------------------------------------GVTFEKKSRVL 889

  Fly  1008 AWFNSDAFEHSAPIALNLVYNALGKAVFEDQDFSILVNRGD-LHDFIWLNNASSMRRRYKRQNDP 1071
            ...|:.|.         |.:....||   |::. |.|:||| |...|..|.|
Worm   890 QLENNQAV---------LYWKDTAKA---DKEL-ITVSRGDALFTMIVQNFA------------- 928

  Fly  1072 DYTDYSDYEIQEYDVVVKPNSSSTSGQHN--KSNPGDDNIITVQMSIIEAASTLYNEKGKRKQLF 1134
                            |....|..:|:|.  |.....:|:.|.  :.|...||::|:....|...
Worm   929 ----------------VSQMISKITGKHPQIKLFLESENVRTA--TEISGFSTVFNDISSSKAAM 975

  Fly  1135 -----GTLIIITAYIALCLSIFSIFVTKERVE-HFKMQQEIYGVTLFYFWSTHFVGD---FLIYA 1190
                 .:|:.|||...:.:..||:.:....|. :...|..|.....:.::...:|..   ||:.|
Worm   976 ILTESYSLMYITAVFQMFVYTFSVVLPLRLVSTNMGPQSMILPWPRYVYFGFIYVFQLVVFLVIA 1040

  Fly  1191 IYMGALTIAIYHF----TIWYQVVVMLLLIGFA-CLPFVYLCSLLFSLPNIAFAGIFAILVMTGG 1250
            |.:|...:::..|    |..|...:....:.:| .||.:|.  |:|::.|.  ..:..|::....
Worm  1041 IILGFAVLSMGFFATNTTSCYLRFLSAWFLSYASTLPLIYF--LVFNIQNT--KSVIPIILAISS 1101

  Fly  1251 MLFSFMYMLTLITDVNFTTVFAILPMYVGTFGLFKCLAWREYCNREVLPPI------------EE 1303
            :..:|..::...:..|          .|....|.:.::|....|    ||.            |.
Worm  1102 LSVTFPNLVASFSAEN----------QVSLQSLIQFVSWSCMLN----PPSSLQVLAAFLNAGES 1152

  Fly  1304 LDCKFGNCN---VFCACKPERTWMEVWLLMVHCLVWFIF---------LWFSN-----FGYEIGY 1351
            |:...|...   :||..       :.|::::..||  ||         .||.:     ..:|.|.
Worm  1153 LEKNSGTITSLILFCGA-------QFWIIVIFVLV--IFQPGFSYIQQYWFKSSTVLYSSFERGT 1208

  Fly  1352 RFKP--KLSNR-IWHNNEKHIRVLDEERRVGL---IP----------KYEHEDY----PIIVDQV 1396
            ..||  ::.|. |:..|.  :..:::.:..|.   ||          :....||    .:.:|.:
Worm  1209 TLKPGARIKNSYIFVTNP--LGTMEDAQDKGASGNIPNRPAAGTEPVQKPTSDYIAGSSMSIDDM 1271

  Fly  1397 T--KNYCRAKNAVQLVSFAIRPGD----------TFGLLGAQGAGKTSIFQMIAGETSMSHGNIY 1449
            :  .||  .:|.|:.::......|          || |:|.|...|:::...||......|
Worm  1272 SYITNY--EENLVEKMATMTSWNDKQEVPVDNSATF-LMGDQTKLKSALLTTIAKINKNEH---- 1329

  Fly  1450 VRGHSLREHRNAAKMEVGFCPQGDNAPKYLTGRQLLR--IHCLLHGVPKDHIKAVSEQMAIEFNF 1512
                            :.|.|..:|.....|..:||.  .:|....:..|||..:.:    .|:.
Worm  1330 ----------------IAFVPIVENISTIYTPFELLENAAYCNGFEITDDHISYLLD----AFDL 1374

  Fly  1513 KDQLDRPIHTYSGGKKRKLN-IALAIDSGSVLCLDDTNGSVDHATQRFIWRKLEAVKRSGRPVLL 1576
            |:..:..|.......:|.|. :|..:...:::.:|.....:.|:....:|.....::::|..::.
Worm  1375 KEHANTQIKLLPCIDRRILMLLAKLVIKPNIVIIDQLEMFLPHSKMMTVWSFCARLRKNGLGIIY 1439

  Fly  1577 TT--QSMEEANAVCSRVAFLVAGEMMFIGSLQQVRSEVSNTIVIRLRVNPSDGK-LKRRFQQLIA 1638
            |:  ....|..|.|  .|.:..|:  |:.:|.....:...|::..:....||.| |....|:.:.
Worm  1440 TSHHSGFAEHTATC--CAHMYKGQ--FVRNLLPTSIKAKCTVLEVVPKTASDPKVLLHMLQKEME 1500

  Fly  1639 DMAEL------FPLATLHEALET 1655
            :..:|      ..||...:.:||
Worm  1501 ESVKLPSTSRNITLAMYKDGVET 1523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31213	NP_001262752.1	ABC2_membrane_3	32..>295	CDD:289468	50/281 (18%)
		ABC_subfamily_A	491..708	CDD:213230	43/216 (20%)
		drrA	498..796	CDD:130256	56/310 (18%)
		ABC2_membrane_3	<1132..1285	CDD:289468	30/166 (18%)
		CcmA	1391..1672	CDD:224054	54/289 (19%)
		ABC_subfamily_A	1391..1609	CDD:213230	43/234 (18%)
abt-1	NP_001293854.1	rim_protein	<256..>676	CDD:130324	90/465 (19%)
		P-loop_NTPase	474..677	CDD:393306	47/233 (20%)
		ABC2_membrane_3	<917..1176	CDD:378925	57/314 (18%)
		CcmA	<1328..1491	CDD:224054	33/190 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160144
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850