Protein Alignment CG31213 and abt-2

DIOPT Version :9

• Sequence 1: NP_001262752.1
• Gene: CG31213 / 42382
• FlyBaseID: FBgn0051213
• Length: 1809
• Species: Drosophila melanogaster
• Sequence 2: NP_490949.3
• Gene: abt-2 / 171782
• WormBaseID: WBGene00000020
• Length: 2146
• Species: Caenorhabditis elegans
• Alignment Length: 1901
• Identity: 416/1901 - (21%)
• Similarity: 786/1901 - (41%)
• Gaps: 431/1901 - (22%)

  Fly    50 AKSIFPPD------IEMEKSPGPKSVNT---SLFVDLYFTPNN-----GILEQLITQLAN----- 95
            |..::|..      |::.|: |...:||   ..|::..|.|::     |...:.||::||
 Worm   472 ASDLWPASQKLLHFIKVYKN-GQNQLNTRTIHFFLEHLFAPSSDEYSFGTYTKNITEIANKYTGC 535

  Fly    96 --------ISEFKSVE-----VFDTNSELYLQLMINRNAIGIAFPS-EWYDIKSCPEVL-NLTIF 145
                    :::.|.:|     :.||: :.:..::.|.::....|.. ..|.|:..||:: :.|.|
 Worm   536 FLLDRFRFVTDEKELETNAVCLMDTH-QYFTGIVFNIDSNATEFDGFTTYKIRHYPEMVDSTTSF 599

  Fly   146 M-----PLSIKRK--DFKYFESGFLLLQERISK-IFIFFKNAGNGKIPRVLMNHFPYPSYVPNHY 202
            |     |.|..:.  |.||...||..|||.|.: |.....|..:..: .|.....|||..|.:.:
 Worm   600 MDSKSNPFSRDKPLIDLKYITFGFSFLQESIDRAIMSELTNQTDANL-GVYAQQEPYPCTVKDTF 663

  Fly   203 AESAKAMTYMTLISFFLPCITIAKYVVAEKERHQKAVLTAMGFSNSIHWLAWYTKSMLLLLLCLL 267
             ..|..|....||||..|...:.|.:|.|||:..|..:.|||..:::|:::|...|::|..:.:|
 Worm   664 -NVALFMPLFLLISFIFPSALLVKNIVYEKEQKIKEQMRAMGLGDAVHFISWGLISLVLNFISVL 727

  Fly   268 IMISIFSIGLIYEFSSLVCLMTIFLVYIHSLVLFAFFISSFFSRSLSAVVATILMYFSTALPFLI 332
            |:..|..:..|::::....|:.:.::::.|.:..:.|.|:.|:.:..|..||.:::|...:||.:
 Worm   728 IISIISKVAKIFDYTDYTLLLFVLILFLFSSIAMSIFFSTLFTNANIATAATCVLWFVFFIPFQL 792

  Fly   333 VGAENSSVAAQTAASIGLNSA----LFYILDSVAVMEMQSVGAQWYTIDNTASSGYKLSIVGYML 393
            :..:..|.......|:.|...    .|.:|:|...||.    |.|..:....:....:|:...|:
 Worm   793 LRTDRISSPTFNRISLILPPTAMGHCFKLLESFNAMER----ATWSDLWEMNNPVLGISVELCMI 853

  Fly   394 IMISISWIELLICLYIEAVRTGEFEVPQPWSYPFQRRYWCPLRYGSSVFHQGALLPLAGKNSEGN 458
            :::..:.:.|::..||.||..|:|.|.||..:||..:||.|..|               ||.
 Worm   854 MLVVDTAVFLILAWYISAVAPGDFGVRQPLWFPFTLKYWAPGLY---------------KNR--- 900

  Fly   459 LPAAHPTRQPIIYLDDR------TQENFQRVNISKKIGIEVRSLSKTFGFRNVVKD-LFFNVYEN 516
                      :.::||.      ..::|.....:..:.:.:.|:||.:.......| |...:||.
 Worm   901 ----------VEFVDDEHFDTIPNSDSFDSEPTNLTLAVHINSMSKVYENGTKALDCLNLRLYEG 955

  Fly   517 EITALVGHKGSGKTTIIMMLCGILQPTTGTVLINGYDIVTEAKVAKSSLGICPQHSVIFKGMSAR 581
            :||.|:||.|:||||.:.:|||:..|::||..|...||.|:.:..:..|||||||:|:|..::..
 Worm   956 QITGLLGHNGAGKTTTMSILCGLYAPSSGTAKIYQRDIRTDLRRVRDVLGICPQHNVLFSHLTVS 1020

  Fly   582 DHIYFFSRVKGYNKTEAMMESNIYISKLGLVDSQKWDAMRLSPGNQRRLSLACALCAGSKVILCD 646
            :.:..|:.:||...:|...:.:..::.:.|.:.....|..||.|.:|||.:..|...||:.::.|
 Worm  1021 EQLRLFAALKGVPDSELTSQVDEILASVSLTEKANKLASTLSGGMKRRLCIGIAFIGGSRFVILD 1085

  Fly   647 EPSSGLDPIGRHELMRFLQKEKHGRTILMTTQQLEEGEILADRIAIMN---------DGQILCYG 702
            ||::|:|...|.::.:.||:.|.|||||::|..::|.::|:|||||::         ||
 Worm  1086 EPTAGVDVTARKDIWKLLQRNKEGRTILLSTHHMDEADVLSDRIAILSQDFEKPDLLDG------ 1144

  Fly   703 TLGYLKQLPFTSY--TLSCQMAPNSKADN--------------LTDLVRLYMTTTTSPVFHGVDV 751
                 |:|.|..:  .|.|::....|:..              |.:|..|...:|..|     |:
 Worm  1145 -----KRLIFQHFYALLVCRINYTLKSKRTFLFQVIIPLFLLALAELFVLLQVSTARP-----DL 1199

  Fly   752 SYKLP-----RSQIDRFPEFF---QQLEENKKSLNVV-------------SFGVSDSTLDGIYLS 795
            ...:|     .|.:....:|:   ....||..:.:::             :..|.:..||.:...
 Worm  1200 MVSMPPLPLETSIMGNHSDFYVNSWDTAENSTANDILHAMFSSPGTGPRCAKDVPNDLLDTMRRE 1264

  Fly   796 L----DYGQGSSRLRGGADPGVNDKVEFGVQTDKAIRTKDRANNSLVRYQHQVDPPNETILNTKT 856
            |    .||.|.::...|.|   .|.|:          .:.:..|....:.:..|..|.|.   ..
 Worm  1265 LMFRNRYGFGRNKPAPGVD---KDSVD----------NEYQCQNIQGEFDYTEDISNATY---NA 1313

  Fly   857 PIN----------PIEIWR----------PIDR---EKGSCMAQWQAM--FIKKKNYTASRALIF 896
            ||.          .:|.|:          ..||   ..|..:.|::.:  |.:..|.||
 Worm  1314 PIYCGCEDFGWNCTLEDWKWNETNWLRLNTTDRIFDLTGRNLTQFRLITRFAQLANTTA------ 1372

  Fly   897 ILILIIPLFYYIIVLGTAASEKCAHRTDKQPVLPLSLDYYSYDDMIILLEVDKQLYKSEGEAYVQ 961
                  |.|     ||..:......|...|..:..|...:        ||..|.:.:|     ::
 Worm  1373 ------PFF-----LGGFSLGHVNQRAQSQADIDTSKRGW--------LETIKDIAQS-----MR 1413

  Fly   962 LVK------EPATVESVDSIFSHLLKAPPI--------IRRDIKRKYVCGASFNNASTITAWFNS 1012
            ::.      ||||.:.:|....::.....:        :|.::|                .|||:
 Worm  1414 IINLNTTGIEPATPKVLDPFAQNITLNQVVNDLLQNLDVRENVK----------------VWFNN 1462

  Fly  1013 DAFEHSAPIALNLVYNALGKAVFEDQDFSILVNRGDLHDFIWLNNASSMRRRYKRQNDPDYTDYS 1077
            ..:. ..|||.|::.|||    ...:|::|
 Worm  1463 KIWP-GFPIASNILSNAL----LRQEDYAI----------------------------------- 1487

  Fly  1078 DYEIQEYDVVVKPNSSSTSGQHNKSNPGDDNIITVQMSIIEAAS-TLYNEKGKRKQLFGT--LII 1139
                                     :|.|..|:|:...:.:..| ||.....|..|....  :.|
 Worm  1488 -------------------------DPEDLGILTMNHPMNKTISQTLDQNALKFTQALAVFRITI 1527

  Fly  1140 ITAYIALCLSIFSIFVTKERVEHFKMQQEIYGVTLFYFWSTHFVGDFLIYAIYMGALTIAIYHFT 1204
            :...:::..:.|::::.::|:......|.:.|:....:|.|.::.|.::|.:.:..:.:....|.
 Worm  1528 LLLVLSMIPAGFTVYLVEDRICEALHLQLVGGLRKVTYWVTSYLYDMVVYTLVIIVIMLIYLCFR 1592

  Fly  1205 I---------WYQVVVMLLLIGFACLPFVYLCSLLFSLPNIAFAGIFAILVMTGGMLFSFMYMLT 1260
            :         ::..:::..:.|.:.:.:.|:....||:..::|     :|:..|......:..||
 Worm  1593 VSDFTADGATFFAFLLLFFVHGMSTILYAYVFQKAFSVAALSF-----VLIAIGSYFVGIVCALT 1652

  Fly  1261 -------LITDVNF-------TTVFAILPMYVGTFGLFKCLA----------WREYCNREVL--- 1298
                   ::.|.:.       :.||.:||.|.....:|:.|.          :.:..||..:
 Worm  1653 VIMLESLMVQDPSLIPAHTVCSIVFLVLPQYNLGIAIFRGLMIYQVRAIGSNFLQQMNRPDMINQ 1717

  Fly  1299 PPIEELDCKFGNCNVFCACKPERTWMEVWLLMVHCLVWFIFLWFSNFGYEIGYRFKPKLSNRIWH 1363
            .|:..| ..|....:...|           |.:|.::..|.|.||... |.|:..|
 Worm  1718 LPLPSL-LAFDQMGIHIMC-----------LFIHVIIATICLIFSQMD-EFGFVRK--------- 1760

  Fly  1364 NNEKHIR---------------VLDEERRVGLIPKYEHEDYPIIVDQVTKNYCRAKNAVQLVSFA 1413
             .|:::.               |:.|.:||..||....:::.:||..:.|.|.....||:.:|||
 Worm  1761 -RERNLTDAMMLREPSTCDDEDVVKERQRVDAIPMDSSDNHALIVRNLAKAYNPELLAVKGISFA 1824

  Fly  1414 IRPGDTFGLLGAQGAGKTSIFQMIAGETSMSHGNIYVRG-----HSLREHRNAAKMEVGFCPQGD 1473
            :.||:.|||||..|||||:.|.|:..:....||:|.::.     .|..:.||.  .::|:|||.|
 Worm  1825 VEPGECFGLLGLNGAGKTTTFAMLTAKIRPGHGSIEMQNTRINTGSFSDVRNF--QQLGYCPQFD 1887

  Fly  1474 NAPKYLTGRQLLRIHCLLHGVPKDHIKAVSEQMAIEFNFKDQLDRPIHTYSGGKKRKLNIALA-I 1537
            .....|:.|:.|:.:..:.|:....|.::.:::.|..:.:...:....:.|||.:|||::|:| :
 Worm  1888 ALNMKLSTRENLKFYARIRGIVPTQIDSIIDRLLIALHLRPYANTQTSSLSGGNRRKLSVAVALV 1952

  Fly  1538 DSGSVLCLDDTNGSVDHATQRFIWRKLEAVKRSGRPVLLTTQSMEEANAVCSRVAFLVAGEMMFI 1602
            ...|::.||:.:..:|..:|:|:|:.:|.:.:||:.|:||:.||||..|:|:|:|.:..|.:..:
 Worm  1953 SQPSLIFLDEPSAGMDPGSQQFLWKVIERLCKSGKAVVLTSHSMEECEALCTRIAIMDRGRIRCL 2017

  Fly  1603 GSLQQVRSEVSNTIVIRLRVNPSDGKLKRRFQQLIADMAELFPLATLHEALETCLIY-HININVT 1666
            |..|.::|:.....::.:::...:..     :::...|.......:..||:....|: ||.....
 Worm  2018 GGKQHLKSKYGKGSMLTMKMGKDENA-----KEIAGIMRSKLGDGSRVEAIHCSTIFIHIEQGTA 2077

  Fly  1667 TLANLFYQMEKIRNEGLLEDYSITQVSLDEIYRILNDEEDPNLVDLDSTHNSEVLEDIRDTTRDT 1731
            ::|.:...:.:::....::|:::||.:||.:::.:  .|..||.:          |....|....
 Worm  2078 SVARVLEIVNQVKKMYDVDDFTLTQSTLDNVFQSI--AESDNLSE----------EGHHGTLSSI 2130

  Fly  1732 TRGTTRDTNLV--SDE 1745
            .|..|..|.::  ||:
 Worm  2131 NRNNTASTYVIHGSDQ 2146

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31213	NP_001262752.1	ABC2_membrane_3	32..>295	CDD:289468	71/286 (25%)
		ABC_subfamily_A	491..708	CDD:213230	75/226 (33%)
		drrA	498..796	CDD:130256	93/344 (27%)
		ABC2_membrane_3	<1132..1285	CDD:289468	26/177 (15%)
		CcmA	1391..1672	CDD:224054	80/287 (28%)
		ABC_subfamily_A	1391..1609	CDD:213230	72/223 (32%)
abt-2	NP_490949.3	rim_protein	39..2117	CDD:130324	407/1860 (22%)
		ABC_subfamily_A	929..1134	CDD:213230	73/204 (36%)
		ABC_subfamily_A	1802..2024	CDD:213230	72/223 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030