DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31213 and Abcg5

DIOPT Version :9

Sequence 1:	NP_001262752.1	Gene:	CG31213 / 42382	FlyBaseID:	FBgn0051213	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	NP_446206.2	Gene:	Abcg5 / 114628	RGDID:	620298	Length:	652	Species:	Rattus norvegicus

Alignment Length:	691	Identity:	139/691 - (20%)
Similarity:	259/691 - (37%)	Gaps:	213/691 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   484 NISKKIG--IEVRSLSKTFGFRNVVKDLFFNVYENEITALVGHKGSGKTTIIMMLCGILQPT--- 543
            ::|.::|  ..::|..:.:. |.::||:...:...:...::|..||||||::..:.|.|:.|
  Rat    47 SVSNRVGPWWNIKSCQQKWD-RKILKDVSLYIESGQTMCILGSSGSGKTTLLDAISGRLRRTGTL 110

  Fly   544 TGTVLINGYDI-----------VTEAKVAKSSLGICPQHSVIFKGM-----SARDHIYFFSRVKG 592
            .|.|.:||.::           :.::.|..|||.:  :.::.:..|     |:.|   |:.:
  Rat   111 EGEVFVNGCELRRDQFQDCVSYLLQSDVFLSSLTV--RETLRYTAMLALRSSSAD---FYDK--- 167

  Fly   593 YNKTEAMME----SNIYISKLGLVDSQKWDAMRLSPGNQRRLSLACALCAGSKVILCDEPSSGLD 653
              |.||::.    |::....:|     .::...:|.|.:||:|:|..|....||::.|||::|||
  Rat   168 --KVEAVLTELSLSHVADQMIG-----NYNFGGISSGERRRVSIAAQLLQDPKVMMLDEPTTGLD 225

  Fly   654 PI-GRHELMRFLQKEKHGRTILMTTQQLEEGEIL--ADRIAIMNDGQILCYGT----LGYLKQL- 710
            .: ..|.::..::..:..|.:::|..| ...|:.  .|:|||:..|:::..||    ||:....
  Rat   226 CMTANHIVLLLVELARRNRIVIVTIHQ-PRSELFHHFDKIAILTYGELVFCGTPEEMLGFFNNCG 289

  Fly   711 --------PFTSYTLSCQMAPNSKADNLTDLVRLYMTTTTSPVFHGVDVSYKLPRSQIDRF---- 763
                    ||..|.....:...|:...:....|:.|..:   .|...|:.:|: ...|:|.
  Rat   290 YPCPEHSNPFDFYMDLTSVDTQSREREIETYKRVQMLES---AFRQSDICHKI-LENIERTRHLK 350

  Fly   764 ------------PEFF-----------QQLEENKKSLNVVSFGVSDSTLDGIYLSLDYGQGSSRL 805
                        |..|           :.|..||:   ||...:..:.:.|::|.....:..:.:
  Rat   351 TLPMVPFKTKNPPGMFCKLGVLLRRVTRNLMRNKQ---VVIMRLVQNLIMGLFLIFYLLRVQNNM 412

  Fly   806 RGGADPGVNDKVEFGVQTDKAIRTKDRANNSLVRYQHQVDPPNETILNTKTPINPIEIWRPI-DR 869
            ..||   |.|:|.                   :.||.....|...:||.   :|...:.|.: |:
  Rat   413 LKGA---VQDRVG-------------------LLYQLVGATPYTGMLNA---VNLFPMLRAVSDQ 452

  Fly   870 EKGSCMAQ-WQAMFIKKKNYTASRALIFILILIIPLFYYIIVLGTAASEKCAHRTDKQPVLPLSL 933
            |....:.| ||                .:|..::....:.||.....|..|
  Rat   453 ESQDGLYQKWQ----------------MLLAYVLHALPFSIVATVIFSSVC-------------- 487

  Fly   934 DYYSYDDMIILLEVDKQLYKSE--------GE----AYVQLVKEPATVESVDSI--FSHLLKAPP 984
                |..:.:..||.:..|.|.        ||    ..:.:|:.|..|.|:.::  .|.||....
  Rat   488 ----YWTLGLYPEVARFGYFSAALLAPHLIGEFLTLVLLGMVQNPNIVNSIVALLSISGLLIGSG 548

  Fly   985 IIRR------DIK-------RKYVC---------GASFNNASTITAWFNS---------DAFEHS 1018
            .||.      .:|       :||.|         |.:|....:.|:..|:         ...|.:
  Rat   549 FIRNIEEMPIPLKILGYFTFQKYCCEILVVNEFYGLNFTCGGSNTSVPNNPMCSMTQGIQFIEKT 613

  Fly  1019 APIALN-------LVYN------ALGKAVFEDQDFSILVNR 1046
            .|.|.:       ::|:      .||..||:.:|:  |::|
  Rat   614 CPGATSRFTTNFLILYSFIPTLVILGMVVFKVRDY--LISR 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31213	NP_001262752.1	ABC2_membrane_3	32..>295	CDD:289468
		ABC_subfamily_A	491..708	CDD:213230	60/246 (24%)
		drrA	498..796	CDD:130256	79/363 (22%)
		ABC2_membrane_3	<1132..1285	CDD:289468
		CcmA	1391..1672	CDD:224054
		ABC_subfamily_A	1391..1609	CDD:213230
Abcg5	NP_446206.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		ABCG_White	50..276	CDD:213201	57/242 (24%)
		3a01204	61..646	CDD:273361	133/667 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000