DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31213 and Abca4

DIOPT Version :9

Sequence 1:	NP_001262752.1	Gene:	CG31213 / 42382	FlyBaseID:	FBgn0051213	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	NP_031404.1	Gene:	Abca4 / 11304	MGIID:	109424	Length:	2310	Species:	Mus musculus

Alignment Length:	2000	Identity:	468/2000 - (23%)
Similarity:	815/2000 - (40%)	Gaps:	471/2000 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NRNLTY--CQKYRLLL--WKDIKLQLTNWVELVMIIFLSALMPIFFSIGTK---VAKSIFPPDIE 59
            |.|.|:  ..:.|.|:  |:::..|:  |              .||...|:   :..::..|.::
Mouse   413 NANSTFEELDRVRKLVKAWEEVGPQI--W--------------YFFEKSTQMTVIRDTLQHPTVK 461

  Fly    60 --MEKSPGPKSVNTSLFVDLYFTPNNGILEQLITQLANISEFKSVEVFDTNSEL------YLQLM 116
              :.:..|.:.:.|...::.:   :||..|:   |..:::.|...::|:.....      ||:.:
Mouse   462 DFINRQLGEEGITTEAVLNFF---SNGPQEK---QADDMTSFDWRDIFNITDRFLRLANQYLECL 520

  Fly   117 I-----------------------NRNAIGIAFPSEWYDIKSCPEVLNLTIFMPLSIKRK----- 153
            :                       ||...|:.||..:....|.|..:...|.|.:.:..|
Mouse   521 VLDKFESYDDEVQLTQRALSLLEENRFWAGVVFPGMYPWASSLPPHVKYKIRMDIDVVEKTNKIK 585

  Fly   154 --------------DFKYFESGFLLLQERISKIFIFFKNAGNGKIP-RVLMNHFPYPSYVPNHYA 203
                          ||:|...||..||:.:.:..:  |:....:.| .|.:...|||.:|.:
Mouse   586 DRYWDSGPRADPVEDFRYIWGGFAYLQDMVEQGIV--KSQMQAEPPIGVYLQQMPYPCFVDD--- 645

  Fly   204 ESAKAMTYMTLISFFLPCITI----------AKYVVAEKERHQKAVLTAMGFSNSIHWLAWYTKS 258
                  ::|.:::...|...:          .|.:|.|||...|..|...|.||::.|..|:..|
Mouse   646 ------SFMIILNRCFPIFMVLAWIYSVSMTVKGIVLEKELRLKETLKNQGVSNAVIWCTWFLDS 704

  Fly   259 MLLLLLCLLIMISIFSIGLIYEFSSLVCLMTIFLVYIHSLVLFAFFISSFFSRSLSAVVATILMY 323
            ..::.|.:.::......|.|..:|....|....|.:..:.::.:|.:|:.||::..|...:.::|
Mouse   705 FSIMALSIFLLTLFIMHGRILHYSDPFILFLFLLAFATATIMQSFLLSTLFSKASLAAACSGVIY 769

  Fly   324 FSTALPFLIVGAENSSVAAQTAASIGLNSALFYILDSVAV---------MEMQSVGAQWYTIDNT 379
            |:..||.::..|....:.|....::.|       |.|||.         .|.|.:|.||..|..:
Mouse   770 FTLYLPHVLCFAWQDRMTADLKTTVSL-------LSSVAFGFGTEYLVRFEEQGLGLQWSNIGKS 827

  Fly   380 ASSGYKLSIVGYMLIMISISWIELLICLYIEAVRTGEFEVPQPWSYPFQRRYWCPLRYGSSVFHQ 444
            ...|.:.|.:..|.:|:..:.:..|:..|::.|..|::..|.||.:..|..||.. ..|.|...:
Mouse   828 PLEGDEFSFLLSMKMMLLDAALYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLG-GEGCSTREE 891

  Fly   445 GALLPLAGKNSEGNLPAAHPTRQPIIYLDDRTQENFQRVNISKKIGIEVRSLSKTF--GFRNVVK 507
            .||........|...| .||        :......|:|.......|:.|::|.|.|  ..|..|.
Mouse   892 RALEKTEPLTEEMEDP-EHP--------EGMNDSFFERELPGLVPGVCVKNLVKVFEPSGRPAVD 947

  Fly   508 DLFFNVYENEITALVGHKGSGKTTIIMMLCGILQPTTGTVLINGYDIVTEAKVAKSSLGICPQHS 572
            .|....|||:|||.:||.|:||||.:.:|.|:|.||:|||||.|.||.|...|.:.|||:||||:
Mouse   948 RLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLIGGKDIETNLDVVRQSLGMCPQHN 1012

  Fly   573 VIFKGMSARDHIYFFSRVKGYNKTEAMMESNIYISKLGLVDSQKWDAMRLSPGNQRRLSLACALC 637
            ::|..::..:||.|::::||.:..||.:|....:...||...:..:|..||.|.||:||:|.|..
Mouse  1013 ILFHHLTVAEHILFYAQLKGRSWEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFV 1077

  Fly   638 AGSKVILCDEPSSGLDPIGRHELMRFLQKEKHGRTILMTTQQLEEGEILADRIAIMNDGQILCYG 702
            ..|||::.|||:||:||..|..:...|.|.:.||||:|:|..::|.::|.|||||::.|::.|.|
Mouse  1078 GDSKVVVLDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIISQGRLYCSG 1142

  Fly   703 TLGYLKQLPFTSYTL--------------------SC------------------QMAPNSKADN 729
            |..:||....|.:.|                    ||                  :...:.....
Mouse  1143 TPLFLKNCFGTGFYLTLVRKMKNIQSQRGGCEGVCSCTSKGFSTRCPTRVDEITEEQVLDGDVQE 1207

  Fly   730 LTDLVRLYMTTTTSPVFHGVDVSYKLPRSQIDR--FPEFFQQLEENKKSLNVVSFGVSDSTLDGI 792
            |.|||..::.........|.::.:.||.....:  :...|::|||....|.:.|||:||:.|:.|
Mouse  1208 LMDLVYHHVPEAKLVECIGQELIFLLPNKNFKQRAYASLFRELEETLADLGLSSFGISDTPLEEI 1272

  Fly   793 YLSL--DYGQGSSRLRGGADPGVNDKVEFGVQTDKAIRTKDRANNSLVRYQH--------QVDPP 847
            :|.:  |.|.||..: |||.   ..:.:.|::...:..|:     .|.:|..        |||||
Mouse  1273 FLKVTEDAGAGSMFV-GGAQ---QKREQAGLRHPCSAPTE-----KLRQYAQAPHTCSPGQVDPP 1328

  Fly   848 NETILNTKTPINPIEIWRPIDREKGSCMAQWQAMFIKKKNYTASRALIFILILIIPLFYYIIVLG 912
            .    ...:| .|.:...|.:......:...||:.:|:.::|......|:..:::|..:..:.|.
Mouse  1329 K----GQPSP-EPEDPGVPFNTGARLILQHVQALLVKRFHHTIRSRKDFVAQIVLPATFVFLALM 1388

  Fly   913 TAASEKCAHRTDKQPVLPL------------SLDYYSYDDMIILLEV------------------ 947
            .:.   ......:.|.|.|            |:|..:.:.:.:|.:|
Mouse  1389 LSI---IVPPFGEFPALTLHPWMYGHQYTFFSMDEPNNEHLEVLADVLLNRPGFGNRCLKEEWLP 1450

  Fly   948 -----------------------DKQLYK----------SEGEAYVQLVKEP----------ATV 969
                                   .||.:.          |..|....|.:.|          .|.
Mouse  1451 EYPCINATSWKTPSVSPNITHLFQKQKWTAAHPSPSCKCSTREKLTMLPECPEGAGGLPPPQRTQ 1515

  Fly   970 ESVD--------SIFSHLLKA-PPIIRRDIKRKYVCGASFNNASTITAWFNSDAFE--------H 1017
            .|.:        :|..:|:|. |.:||..:|.|:              |.|...:.        .
Mouse  1516 RSTEVLQDLTNRNISDYLVKTYPALIRSSLKSKF--------------WVNEQRYGGISIGGKLP 1566

  Fly  1018 SAPIA----------LNLVYNALGKAVFEDQDFSILVNRGDLHDF-----------IWLNNA--- 1058
            :.||:          |..:.|..|..|..:....:|       ||           :|.||.
Mouse  1567 AIPISGEALVGFLSGLGQMMNVSGGPVTREASKEML-------DFLKHLETTDNIKVWFNNKGWH 1624

  Fly  1059 -----------SSMRRRYKRQNDPDYTDYSDYEIQEYDVVVKPNSSSTSGQHNKSNPGDDNIITV 1112
                       :.:|....|..||          :||.:.|            .|.|  .|:...
Mouse  1625 ALVSFLNVAHNAILRASLPRDRDP----------EEYGITV------------ISQP--LNLTKE 1665

  Fly  1113 QMSIIEAASTLYNEKGKRKQLFGTLIIITAYIALCL--------SIFSIFVTKERVEHFKMQQEI 1169
            |:|.|...:|                .:.|.:|:|:        :.|.:::.:|||...|..|.|
Mouse  1666 QLSDITVLTT----------------SVDAVVAICVIFAMSFVPASFVLYLIQERVTKAKHLQFI 1714

  Fly  1170 YGVTLFYFWSTHFVGDFLIYAIYMGALTIAIYHFTIWYQ------------VVVMLLLIGFACLP 1222
            .||:...:|.|:|:.|.:.||:..| |.:.|:   |.:|            :|.:|:|.|:|.:|
Mouse  1715 SGVSPTTYWLTNFLWDIMNYAVSAG-LVVGIF---IGFQKKAYTSPDNLPALVSLLMLYGWAVIP 1775

  Fly  1223 FVYLCSLLFSLPNIAFAGIFAILVMTGGMLFSFMYMLTLITDVNFTTVF-AILPMYVGTFGLFKC 1286
            .:|..|.||.:|:.|:..:....:..|....:..::|.|..:......| |:|...:..|..| |
Mouse  1776 MMYPASFLFEVPSTAYVALSCANLFIGINSSAITFVLELFENNRTLLRFNAMLRKLLIVFPHF-C 1839

  Fly  1287 LAWREYCNREVLPPIEELDCKFG---NCNVFCACKPERTW----MEVWLLMVHCLVWFI------ 1338
            |. |...:..:...:.::..:||   :.|.|       .|    ..:..:.:..:|:|:
Mouse  1840 LG-RGLIDLALSQAVTDVYAQFGEEYSANPF-------QWDLIGKNLVAMAIEGVVYFLLTLLIQ 1896

  Fly  1339 ---FL--WFSNFGYEIGYRFKPKLSNRIWHNNEKHIRVLDEERRVGLIPKYEHEDYPIIVDQVTK 1398
               ||  |.:....|..:.....::       |:..||:....:..::.          ::::||
Mouse  1897 HHFFLTRWIAEPAREPVFDEDDDVA-------EERQRVMSGGNKTDILK----------LNELTK 1944

  Fly  1399 NYCRAKN-AVQLVSFAIRPGDTFGLLGAQGAGKTSIFQMIAGETSMSHGNIYVRGHSLREHRNAA 1462
            .|..:.: ||..:...:|||:.|||||..|||||:.|:|:.|:|:::.|:..|.|.|:....:..
Mouse  1945 VYSGSSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTSISDV 2009

  Fly  1463 KMEVGFCPQGDNAPKYLTGRQLLRIHCLLHGVPKDHIKAVSEQMAIEFNFKDQLDRPIHTYSGGK 1527
            ...:|:|||.|.....||||:.|.::..|.|||...|:.|:.............||...|||||.
Mouse  2010 HQNMGYCPQFDAIDDLLTGREHLYLYARLRGVPSKEIEKVANWGIQSLGLSLYADRLAGTYSGGN 2074

  Fly  1528 KRKLNIALAIDS-GSVLCLDDTNGSVDHATQRFIWRKLEAVKRSGRPVLLTTQSMEEANAVCSRV 1591
            ||||:.|:|:.. ..:|.||:....:|...:|.:|..:.::.|.||.|:||:.||||..|:|:|:
Mouse  2075 KRKLSTAIALTGCPPLLLLDEPTTGMDPQARRMLWNTIVSIIREGRAVVLTSHSMEECEALCTRL 2139

  Fly  1592 AFLVAGEMMFIGSLQQVRSEVSNTIVIRLRV-NPSDGKLKRRFQQLIADMAEL-------FPLAT 1648
            |.:|.|....:|::|.::.:..:..::.::: :|.|        .|:.|:..:       ||.:.
Mouse  2140 AIMVKGTFQCLGTIQHLKYKFGDGYIVTMKIKSPKD--------DLLPDLNPVEQFFQGNFPGSV 2196

  Fly  1649 LHEALETCLIYHININVTTLANLFYQMEKIRNEGLLEDYSITQVSLDEIY 1698
            ..|...:.|  ...:..::||.:|..:...::..|:|:||:||.:||:::
Mouse  2197 QRERHHSML--QFQVPSSSLARIFQLLISHKDSLLIEEYSVTQTTLDQVF 2244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31213	NP_001262752.1	ABC2_membrane_3	32..>295	CDD:289468	59/326 (18%)
		ABC_subfamily_A	491..708	CDD:213230	93/218 (43%)
		drrA	498..796	CDD:130256	117/339 (35%)
		ABC2_membrane_3	<1132..1285	CDD:289468	42/173 (24%)
		CcmA	1391..1672	CDD:224054	89/290 (31%)
		ABC_subfamily_A	1391..1609	CDD:213230	79/219 (36%)
Abca4	NP_031404.1	rim_protein	1..2271	CDD:130324	468/1999 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..910		4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1311..1344		9/37 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2266..2310
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838461
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.860